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All Journal Jurnal Sehat Mandiri
Hidayat, Muhammad Naufal Nurhadi
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Environmental Science Public Health

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Literature Review : Analisis Senyawa Kimia sebagai Kandidat Obat Kanker Paru Menggunakan Metode Molecular Docking Hidayat, Muhammad Naufal Nurhadi; Alinu Mulki, Munir; Dwiputri Prihasti, Nurlita
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i2.1869

Abstract

Lung cancer is the leading cause of death worldwide, so the development of effective drugs is urgently needed. This study aims to identify potential chemical compounds as lung cancer drug candidates through molecular docking analysis. This study used a narrative literature review method with data collected from PubMed using specific keywords such as "Molecular docking," "Lung cancer," "Drug candidate," "Chemistry," and "Compound" for articles published between 2019 and 2024. Inclusion criteria included studies that analyzed chemical compounds as lung cancer drug candidates using molecular docking and met certain quantitative criteria. Of the initial 123 articles, 10 articles met the inclusion criteria and were analyzed further. The results showed significant interactions between several chemical compounds and lung cancer-related protein targets such as P-glycoprotein, NEK7, EGFR, VEGFR-2, and topoisomerase II, with high binding affinity. Overall, the results of this review highlight compound 762, SIQ17, and compound 7 as lead candidates with high therapeutic potential, which deserve further development through in vitro and in vivo tests to support their application in lung cancer therapy.
Narrative Review: Parameter dalam Metode Analisis untuk Identifikasi Rhodamin B dalam Lipstik Prihasti, Nurlita Dwi Putri; Mulki, Munir Alinu; Hidayat, Muhammad Naufal Nurhadi
Jurnal Sehat Mandiri Vol 19 No 1 (2024): Jurnal Sehat Mandiri, Volume 19, No.1 Juni 2024
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v19i1.1385

Abstract

Rhodamine B is a synthetic dye used in the paper and textile industries, attracting attention due to its potential health hazards. It is used in various cosmetic products, although the Regulation of the Minister of Health of Indonesia No. 445/MENKES/PER/V/1998 prohibits its use in cosmetics due to risks of irritation, liver damage, and cancer. This article reviews the parameters of analytical methods for identifying Rhodamine B in lipstick. A narrative review was conducted using Google Scholar as a database over the past 10 years. The KLT method was found to be more widely used than HPLC or UV-Vis Spectrophotometry. Differences in Rf values in KLT are due to variations in the stationary phase. Parameter variations in HPLC system suitability tests are caused by operational conditions, sample conditions, and instrument performance. Analytical methods for identifying Rhodamine B in lipstick include KLT, HPLC/KCKT, and UV-Vis Spectrophotometry. It is concluded that each method has specific parameters that must be met: KLT is qualified if the Rf value comparison (standard vs. sample) is ≤ 0.2; HPLC/KCKT requires system suitability and validation tests; UV-Vis Spectrophotometry needs validation test parameters. KLT is preferred due to easy sample preparation and lower costs compared to HPLC and UV-Vis Spectrophotometry. It is recommended to consider necessary components when using these methods to maximize test results.
Co-Authors Dwiputri Prihasti, Nurlita Munir Alinu Mulki Prihasti, Nurlita Dwi Putri Ramadhani, Rima Putri Wulandari, Sophy