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All Journal Jurnal Ilmiah Kesehatan (JIKA) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Wijaya, Bayu Basuki
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Health Professions Medicine & Pharmacology Nursing Public Health

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Radiographic findings and body mass index in elderly patients with knee osteoarthritis: A cross-sectional study Lie, Yose Steven; Kusumaningrum, Sulistyani; Budiningsih , Fatichati; Wijaya, Bayu Basuki
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art3

Abstract

Background: Osteoarthritis (OA) is a chronic condition characterized by the gradual wearing down of joint cartilage. Its prevalence is increasing due to aging populations and obesity rates. The Kellgren and Lawrence classification system is commonly used to assess OA severity based on radiologic findings.Objective: This study aims to determine the relationship between body mass index (BMI) and the radiological severity of knee OA as classified by the Kellgren and Lawrence system, in elderly patients.Methods: We conducted a cross-sectional analysis of outpatients diagnosed with knee OA at a Dr. Moewardi Regional Public Hospital from January 2020 to August 2023. Patient records and knee X-rays graded by the Kellgren and Lawrence system were reviewed. Two radiologists independently assessedthe X-rays to ensure accuracy. BMI was calculated using the formula weight (kg) divided by height (m2), with weight and height measured suing calibrated instruments. Spearman's rho bivariate correlation analysis was performed to analyze the data.Results: A total of 96 patients were analyzed, with the majority being female (62.50%) and aged 60-69 years (59.30%). The most prevalent OA severity was grade 3 (46.89%), and the most common OA location was bilateral (73.96%). There was a significant moderate correlation between Kellgren & Lawrence and BMI (p=0.000; rho=0.401).Conclusion: A moderate correlation exists between the severity of knee OA and BMI in elderly patients. Those with a higher BMI tend to present with more severe OA.
Vitamin D3 on Oxidative Stress Markers and Blood Pressure in a UUO Rat Model of Chronic Kidney Disease Wibowo, Yogo Pardi; Susanto, Agung; Wijaya, Bayu Basuki; Pamungkasari, Eti Poncorini; Pramana, Triyanta Yuli
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1431

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Chronic kidney disease (CKD) is a major global health burden, with oxidative stress and hypertension contributing significantly to its progression. Although vitamin D3 is known for its pleiotropic effects, its influence on oxidative stress markers in obstructive nephropathy remains unclear. This study evaluated the effect of vitamin D3 supplementation on blood pressure, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) activity in a rat model of CKD induced by Unilateral Ureteral Obstruction (UUO). In this experimental post-test-only control group study, 30 male white rats (Rattus norvegicus) were randomly assigned to five groups (n = 6 per group) following UUO induction: one control group (placebo) and four treatment groups receiving graded oral doses of vitamin D3 (36, 72, and 108 IU/rat) daily for 14 days. Blood pressure was measured using the tail-cuff method, and serum MDA levels and SOD activity were analyzed at the end of the treatment period. Vitamin D3 supplementation produced significant, dose-dependent improvements in all parameters (p-value < 0,01). Compared with controls, treated groups showed lower blood pressure, reduced MDA levels, and increased SOD activity. The highest dose (108 IU/rat) demonstrated the greatest reduction in oxidative stress and blood pressure. This study aimed to evaluate whether vitamin D3 supplementation ameliorates hypertension and oxidative stress in UUO-induced CKD in rats, supporting its potential as an adjunctive strategy to slow CKD progression. Further studies are required to confirm clinical applicability.
Co-Authors Budiningsih , Fatichati Eti Poncorini Pamungkasari Kusumaningrum, Sulistyani Lie, Yose Steven Susanto, Agung Triyanta Yuli Pramana Wibowo, Yogo Pardi