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All Journal The Indonesian Biomedical Journal Indonesian Journal of Medicine JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Plexus Medical Journal
Kusumaningrum, Sulistyani
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Differences in Age Estimated by the Kvaal Method on Right and Left Mandibular Canines Kusumaningrum, Sulistyani; Wasita, Brian; Wujoso, Hari; Rahayu, Rachmi Fauziah; Hermansyah, Muhamad Lukman; Lawei, Tharina
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.495 KB) | DOI: 10.26911/theijmed.2021.6.2.401

Abstract

Background: The radiographic method for deter­mining the estimated age has the advantage of being non-invasive and the orthopantomogram images are digitally processed. Canines have a strong corre­la­tion with chronological age and have good resistance and large pulp space. This study aimed to determine the difference in age estimates using the Kvaal method on the right and left mandibular canines.Subjects and Method: There were 80 ortho­pantomogram samples from dental and oral clinic patients who had undergone orthopantomography at the Radiology Installation of Dr. Moewardi Hos­pital, from January 2019 to December 2020. The estimated age of right and left canines was calcu­lated based on the Kvaal method and performed a T-test.Results: At the estimated age of the right and left mandibular canines determined by the Kvaal formula, the T-test was performed showing a mean of 38.3 years for the right mandibular canine (Mean= 38.3; SD= 6.7) and 38.2 year the left mandi­bular canine (Mean= 38.2; SD= 8.9), with p = 0.910. Data analysis showed that there was no difference in age estimation using the Kvaal method on the right and left mandibular canines.Conclusion: There was no difference in age estimates by the Kvaal method on the right and left mandibular canines.Keywords: Oratopantomogram, Metoday Qual, Kaninus MandibulaCorrespondence: Sulistyani Kusumaningrum. Department of Radiology Dr. Moewardi Hospital / Faculty of Medicine Universitas Sebelas Maret, Surakarta. Email: kusumasulis1@gmail.com.Indonesian Journal of Medicine (2021), 06(02): 206-211https://doi.org/10.26911/theijmed.2021.06.02.09
The Relationship between Tumor Size and Carcinoembryonic Antigen (CEA) Levels in Stage IV Colorectal Adenocarcinoma Patients at Dr. Moewardi Hospital, Indonesia Eri, Rakhmawati Susetyaning; Kusumaningrum, Sulistyani; Widiastuti, Widiastuti; Wujoso, Hari; Adnyana, Ida Bagus Budhi Surya; Putro, Prasetyo Sarwono
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.994 KB) | DOI: 10.26911/theijmed.2021.6.3.419

Abstract

Background: Colorectal adenocarcinoma is one of the most common types of colorectal cancer based on histopathology, accounting for about 10% of cancer cases diagnosed worldwide each year. Tumor size and levels of carcinoembryonic antigen (CEA) are used to determine the presence and evaluation of colorectal cancer. However, studies on the correlation between the size of colorectal cancer based on CT scan abdominal with contrast and the CEA levels are still very minimal in the Indonesian population. This study aimed to analyze the relationship between tumor size examined by abdominal CT scan with contrast and carcinoembryonic antigen (CEA) levels in stage IV colorectal adenocarcinoma patients.Subjects and Method: A cross-sectional study was conducted at the radiology department, Dr. Moewardi hospital, Surakarta, from February 2021 to July 2021. A total of 40 patients with stage IV colorectal adenocarcinoma were selected in this study. The patient already had the examination results of blood CEA levels and performed an abdominal CT scan with contrast. The dependent variable was blood CEA levels. The independent variable was tumor size. Data were collected from medical records and analyzed by the Spearman test.Results: There was a positive and significant relationship between tumor size and CEA levels (r= 0.47; p= 0.003).Conclusion: Tumor size is positively correlated to blood CEA levels in patients with stage IV colorectal adenocarcinoma.Keywords: colorectal adenocarcinoma, contrast abdominal CT scan, carcinoembryonic antigen (CEA).Correspondence: Sulistyani Kusumaningrum. Department of Radiology Dr. Moewardi Hospital/ Faculty of Medicine of Universitas Sebelas Maret, Surakarta. Email: sulistyani_sprad@staff.uns.ac.idIndonesian Journal of Medicine (2021), 06(03): 285-290https://doi.­org/10.26911/theijmed.2021.06.03.05
Correlation Between Analgesic Administration, Depression, and Knee Osteoarthritis Severity in Elderly Gutomo, Arthur Marc; Kusumaningrum, Sulistyani; Budiningsih, Fatichati; Werdiningsih, Yulyani
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.772

Abstract

Background: Chronic diseases in the elderly, including osteoarthritis (OA), impact quality of life and can lead to depression. Pain caused by knee osteoarthritis may trigger stress and depression, while depression can worsen pain perception and disability. This study aimed to analyze the correlation between analgesic use, depression, and the severity of knee osteoarthritis in elderly patients. Subjects and Method: A cross-sectional study was conducted at Dr. Moewardi Hospital, Surakarta, using medical records of 99 elderly patients diagnosed with primary knee osteoarthritis between January 2018 and January 2024. Analgesic administration data were obtained from prescription records. Depression levels were assessed using the Geriatric Depression Scale (GDS), while the severity of osteoarthritis was evaluated using the Kellgren and Lawrence radiological classification. Data were analyzed using the Spearman correlation test. Results: Analgesic administration was negatively associated with depression (OR= 0.09; 95% CI= 0.03 to 0.32; p<0.001) and severity of knee OA (OR= 1.91; 95% CI= 0.60 to 6.08; p<0.001). Severity of knee OA was positively associated with depression (OR= 0.18; 95% CI= 0.05 to 0.62; p<0.001). Conclusion: Analgesic administration is negatively associated with depression and severity of knee OA. Severity of knee OA is positively associated with depression.
Radiographic findings and body mass index in elderly patients with knee osteoarthritis: A cross-sectional study Lie, Yose Steven; Kusumaningrum, Sulistyani; Budiningsih , Fatichati; Wijaya, Bayu Basuki
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art3

Abstract

Background: Osteoarthritis (OA) is a chronic condition characterized by the gradual wearing down of joint cartilage. Its prevalence is increasing due to aging populations and obesity rates. The Kellgren and Lawrence classification system is commonly used to assess OA severity based on radiologic findings.Objective: This study aims to determine the relationship between body mass index (BMI) and the radiological severity of knee OA as classified by the Kellgren and Lawrence system, in elderly patients.Methods: We conducted a cross-sectional analysis of outpatients diagnosed with knee OA at a Dr. Moewardi Regional Public Hospital from January 2020 to August 2023. Patient records and knee X-rays graded by the Kellgren and Lawrence system were reviewed. Two radiologists independently assessedthe X-rays to ensure accuracy. BMI was calculated using the formula weight (kg) divided by height (m2), with weight and height measured suing calibrated instruments. Spearman's rho bivariate correlation analysis was performed to analyze the data.Results: A total of 96 patients were analyzed, with the majority being female (62.50%) and aged 60-69 years (59.30%). The most prevalent OA severity was grade 3 (46.89%), and the most common OA location was bilateral (73.96%). There was a significant moderate correlation between Kellgren & Lawrence and BMI (p=0.000; rho=0.401).Conclusion: A moderate correlation exists between the severity of knee OA and BMI in elderly patients. Those with a higher BMI tend to present with more severe OA.
Vitamin D and Magnesium Combination Lowers High-Sensitivity C-Reactive Protein, Interleukin-12, Renin, and Carotid Vessel in Diabetic Rats Rahayu, Rachmi Fauziah; Zahrah, Fathimah Afifah; Anugrah, Tessa Septian; Yudhani, Ratih Dewi; Yueniwati, Yuyun; Irawan, Amelia Tjandra; Kusumaningrum, Sulistyani; Fauzi, Adam; Wasita, Brian; Wiyono, Nanang; Muthaminah, Muthaminah; Sholikah, Tri Agusti; Wardhani, Lusi Oka; Suyatmi, Suyatmi; Yarso, Kristanto Yuli; Pesik, Riza Novierta; Siswanto, Febby Gunawan
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.4061

Abstract

BACKGROUND: Diabetes mellitus induces oxidative stress, inflammation, and endothelial dysfunction, accelerating atherosclerosis development marked by elevated high-sensitivity C-reactive protein (hs-CRP) and interleukin-12 (IL-12). Diabetes often causes significant vascular changes, which can be represented by carotid tunica intima thickening and elevated renin level. Metformin, which remains as the standard therapy, has limited vascular effects. Vitamin D and magnesium exhibit vasoprotective and anti-inflammatory properties; however, their combined effects on diabetic vascular injury remain unclear. This study evaluated the effects of vitamin D and magnesium combination on serum hs-CRP, IL-12, renin, and carotid tunica intima thickness in diabetic rats.METHODS: Wistar rats were diabetic-induced by 45 mg/kg streptozotocin and 110 mg/kg nicotinamide. Following the induction, the rats were subsequently assigned to receive no treatment, metformin, or a combination of vitamin D and magnesium. Healthy rats were also included as control. Blood sample was collected after 21 days of treatment. Serum hs-CRP, IL-12, and renin were measured using enzyme-linked immunosorbent assay (ELISA), while the carotid tunica intima thickness was assessed by Doppler ultrasound.RESULTS: Diabetic rats showed significant increases hs-CRP, IL-12, renin level, and intima thickness (p<0.001) compared to control. Both metformin and combination of Vitamin D and magnesium reduced these parameters, with combination of Vitamin D and magnesium showing the greatest improvement. Carotid intima thickness in the combination of Vitamin D and magnesium group was comparable to normal controls, indicating marked vascular protection.CONCLUSION: Vitamin D and magnesium combination provided superior glycemic, anti-inflammatory, and vascular protective effects compared to metformin alone. This adjunctive strategy might have potential in preventing vascular complications in diabetes.KEYWORDS: diabetes mellitus, oxidative stress, endothelial dysfunction, hs-CRP, IL-12, atherosclerosis
Hubungan Pengetahuan dan Kesadaran terhadap COVID-19 dengan Asupan Vitamin D dan Seng pada Mahasiswa Kedokteran UNS Muhammad Daffa Ardiawan; Ayusari, Amelya Augusthina; Kusumaningrum, Sulistyani
Plexus Medical Journal Vol. 2 No. 2 (2023): April
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v2i2.615

Abstract

Pendahuluan: COVID-19 telah ditetapkan sebagai pandemi global oleh World Health Organization (WHO). Pengetahuan dan kesadaran yang berhubungan dengan COVID-19 pada mahasiswa khususnya mahasiswa kedokteran sudah baik. Penelitian telah membuktikan vitamin D berperan sebagai imunomodulator sistem kekebalan tubuh dan seng yang memiliki peran dalam kekebalan antivirus termasuk coronavirus. Oleh sebab itu, penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dan kesadaran terhadap COVID-19 dengan asupan vitamin D dan seng pada mahasiswa kedokteran Universitas Sebelas Maret. Metode: Penelitian yang digunakan adalah observasional analitik dengan pendekatan cross-sectional. Subjek penelitian ini adalah mahasiswa kedokteran UNS dengan kriteria inklusi. Subjek dipilih dengan metode simple random sampling dengan jumlah 91 responden yang memenuhi kriteria inklusi. Data dianalisis dengan metode Spearman. Hasil: Hasil penelitian didapatkan hubungan lemah dan tidak signifikan antara pengetahuan dan kesadaran terhadap COVID-19 dengan asupan vitamin D dan seng. Hubungan Pengetahuan dan kesadaran terhadap asupan vitamin D memiliki koefisien masing-masing r = 0.257 dan r = 0.129. Hubungan pengetahuan dan kesadaran terhadap asupan seng memiliki koefisien masing-masing r = 0.057 dan r = 0.112. Kesimpulan: Didapatkan hasil berupa hubungan lemah dan tidak signifikan antara pengetahuan dan kesadaran terhadap COVID-19 dengan asupan vitamin D dan seng pada mahasiswa kedokteran Universitas Sebelas Maret  
Co-Authors Adam Fauzi Adnyana, Ida Bagus Budhi Surya Anugrah, Tessa Septian Ayusari, Amelya Augusthina Brian Wasita Budiningsih , Fatichati Budiningsih, Fatichati Eri, Rakhmawati Susetyaning Gutomo, Arthur Marc Hari Wujoso Hermansyah, Muhamad Lukman Irawan, Amelia Tjandra LAWEI, THARINA Lie, Yose Steven Muhammad Daffa Ardiawan Muthaminah, Muthaminah Nanang Wiyono Putro, Prasetyo Sarwono Rachmi Fauziah Rahayu Ratih Dewi Yudhani Riza Novierta Pesik Sholikah, Tri Agusti Siswanto, Febby Gunawan Suyatmi Suyatmi Wardhani, Lusi Oka Werdiningsih, Yulyani WIDIASTUTI - Wijaya, Bayu Basuki Yarso, Kristanto Yuli Yuyun Yueniwati Zahrah, Fathimah Afifah