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All Journal Jurnal Pembelajaran dan Biologi Nukleus Jurnal Pijar MIPA
Hitopik, Asman
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Physics

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Influence of LEAP2 (Liver Expressed Antimicrobial Peptide-2) and Ghrelin Binding to GHSR Gene Receptor as Factors Obesity Incidence: A Literature Review Hitopik, Asman; Kasasiah, Ahsanal; Malau, Jekmal
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 10, No 3: Jurnal Pembelajaran Dan Biologi Nukleus November 2024
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v10i3.5834

Abstract

Obesity is a serious issue in global health, which requires a more comprehensive understanding for the development of effective therapies. This study explores the role of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) and its interaction with Ghrelin in regulating Growth Hormone Secretagogue Receptor (GHSR) as a potential obesity event. This method used in this review is a systematic literature analysis. The results obtained show that LEAP2, originally known as an antimicrobial, plays a significant role in metabolic regulation and body weight regulation. LEAP2 acts as a Ghrelin antagonist, reduces orexigenic effects and inhibits food intake, and exerts positive effects in tackling the effects of obesity such as hyperlipidemia and inflammation. The study also highlighted the potential of LEAP2 as a therapeutic target in obesity treatment, with palmitoylation modification showing increased stability and effectiveness of LEAP2. However, further understanding and clinical trial studies are needed to validate the preclinical findings and evaluate the long-term effects of LEAP2 regulation on human body weight and metabolic health, thus providing a basis for exploring potential clinical applications in future anti-obesity drug development
Marine-Derived Chitosan Biopolymers as Antibacterial Agents: A Review Nurhadis, Nurhadis; Kasasiah, Ahsanal; Hitopik, Asman
Jurnal Pijar Mipa Vol. 19 No. 6 (2024): November 2024
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v19i6.8021

Abstract

The growing issue of bacterial resistance to conventional antibiotics has led to an increasing need for alternative antimicrobial agents. Chitosan, a biopolymer derived from marine organisms such as crustaceans (shrimp, crabs) and mollusks (shellfish), has shown significant antibacterial properties. This systematic review aims to evaluate the antibacterial activity of chitosan extracted from various marine sources against Gram-positive (Staphylococcus epidermidis) and Gram-negative (Escherichia coli) bacteria. A comprehensive search of studies published in the past decade was conducted across multiple databases, using predefined inclusion criteria to identify relevant experimental research that focused on quantitative data, such as inhibition zones. The review analyzes key variables, including chitosan extraction methods, concentrations, and experimental conditions. The results revealed that chitosan exhibited the highest antibacterial activity against E. coli, while S. epidermidis showed moderate susceptibility. Variations in antibacterial effectiveness were attributed to differences in chitosan extraction methods and experimental conditions. Despite these variations, the overall evidence supports the potential of chitosan as an effective antimicrobial agent, demonstrating significant inhibition against a wide range of bacterial strains. The findings suggest that chitosan may serve as a promising natural alternative to combat bacterial infections, particularly those caused by antibiotic-resistant pathogens. However, further research is needed to standardize extraction techniques, explore the antibacterial mechanisms, and conduct in vivo studies to validate its clinical applications. These findings underscore chitosan's potential as a sustainable and effective solution in addressing the global challenge of bacterial resistance.
Co-Authors Ahsanal Kasasiah Jekmal Malau Nurhadis, Nurhadis