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All Journal Jurnal Sains Farmasi dan Kesehatan Jurnal Riset Multidisiplin Edukasi
Nabila Syifa Firdaus
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Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Formulasi Sediaan Tablet Dan Evaluasi Dari Jenis Zat Aktif Dengan Metode Granulasi Basah Jaida Rahma; Alya Puspita Dewi; Septia Miranti; Hendri Anugrah Wibowo; Nabila Syifa Firdaus
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 2 (2024): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i2.1791

Abstract

This study aims to understand how the wet granulation technique can affect the physical quality and the effectiveness of active ingredient release in tablets. In this review, various types of active ingredients will be analyzed to evaluate how their chemical and physical properties, such as solubility, compressibility, and stability, influence the resulting tablet formulation. Wet granulation was chosen due to its ability to improve the flow, compressibility, and stability of the mixture of active ingredients and excipients, resulting in tablets with better quality. To achieve this objective, the study uses a Systematic Literature Review (SLR) approach, which gathers and analyzes relevant literature related to tablet formulations with active ingredients using wet granulation. The results of the review show that wet granulation is effective in improving the physical quality of tablet and granule preparations. Wet granulation can enhance flow, compressibility, and active ingredient release control, although it has drawbacks, such as high costs and multiple stages that require validation. Increasing the concentration of gelatin in the tablet formulation of Eugenia polyantha extract improved the physical strength and dissolution rate of the tablets. Similarly, research on acetaminophen demonstrated that wet granulation produces tablets with physical qualities that meet the required standards for tablet physical testing. Finally, this study shows that Tectona grandis leaf extract can be formulated into granules with optimal quality that meets the physical evaluation criteria. Overall, wet granulation has proven to be effective in improving the quality and release of active ingredients in tablets and granules, with the selection of appropriate materials and concentrations greatly affecting the final formulation results.
PENGEMBANGAN SISTEM PENGEMASAN CERDAS BERBASIS NANOSENSOR: KUALITAS PANGAN DAN OBAT-OBATAN Amanda Cahyani; Nabila Syifa Firdaus; Nor Latifah
Jurnal Riset Multidisiplin Edukasi Vol. 2 No. 6 (2025): Jurnal Riset Multidisiplin Edukasi (Edisi Juni 2025)
Publisher : PT. Hasba Edukasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71282/jurmie.v2i6.521

Abstract

Nanosensor-based smart packaging is a leading innovation in ensuring the quality and safety of food and drug products. This technology combines nanomaterials with advanced sensory systems to monitor the condition of products in real-time throughout the supply chain. The system allows for early detection of changes in temperature, humidity, pH, decay gases, and microorganisms, and provides accurate information on product quality. The nanosensors used have advantages in high sensitivity, selectivity, and stability. Despite facing technical challenges such as integration into packaging materials and production sustainability, the development of synthesis methods and fabrication technologies continues to overcome these constraints. The implementation of this smart packaging system has proven to be effective in extending shelf life, improving safety, and reducing product waste. Thus, nanosensors in smart packaging promise sustainable future solutions for the food and pharmaceutical industries.
Tinjauan Teknik Spektroskopi dalam Analisis Senyawa Kimia dan Bahan Alam Rahima, Ghina; Anisa Nazwa; Khairatunnisa; Lili Sa’adah; Nabila Syifa Firdaus; Nita Rahmadani; Nur Prettiya Shalha; Sofi Agusti Putri
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3187

Abstract

Penelitian ini bertujuan untuk mengkaji dan mengevaluasi efektivitas empat teknik spektroskopi utama—FTIR, UV-Vis, GC-MS, dan NMR—dalam analisis senyawa kimia dan bahan alam. Kajian ini menggunakan metode studi pustaka dengan menganalisis berbagai sumber ilmiah yang relevan untuk memahami peran dan penerapan teknik-teknik tersebut dalam identifikasi dan karakterisasi senyawa aktif pada tanaman obat, produk farmasi, kosmetik, hingga pangan. FTIR digunakan secara luas untuk mendeteksi gugus fungsi dalam senyawa bioaktif seperti flavonoid dan alkaloid secara cepat dan non-destruktif. UV-Vis menonjol dalam analisis kuantitatif senyawa fenolik dan flavonoid melalui pengukuran absorbansi pada panjang gelombang tertentu. Sementara itu, GC-MS mampu memisahkan dan mengidentifikasi senyawa volatil secara presisi melalui kombinasi kromatografi dan spektrometri massa, seperti dalam minyak atsiri atau senyawa aromatik. Teknik NMR memberikan informasi struktural paling lengkap dan akurat terhadap susunan atom dan interaksi molekul dalam senyawa organik, meskipun memerlukan biaya dan keahlian tinggi. Setiap teknik memiliki kekuatan dan keterbatasan tersendiri, namun integrasi penggunaannya dapat memperkuat validasi dan akurasi dalam studi senyawa bahan alam. Dalam banyak penelitian, kombinasi spektroskopi dan pendekatan kemometrik seperti PCA dan PLS juga memperkuat akurasi identifikasi dan deteksi kualitas produk. Hasil tinjauan ini menunjukkan bahwa pemanfaatan spektrum spektroskopi secara sinergis sangat penting untuk mendukung pengembangan obat herbal, kosmetik alami, dan produk pangan berbasis tumbuhan secara efisien, akurat, dan berstandar ilmiah.
Co-Authors Alya Puspita Dewi Amanda Cahyani Anisa Nazwa Hendri Anugrah Wibowo Jaida Rahma Khairatunnisa Lili Sa’adah Nita Rahmadani Nor Latifah Nur Prettiya Shalha Rahima, Ghina Septia Miranti Sofi Agusti Putri