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All Journal Indonesian Journal of Health Sciences Research and Development (IJHSRD) Indonesian Journal of Health Research and Development
Danjuma, Kabir
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Health Professions Medicine & Pharmacology Nursing Public Health

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Phytochemical Screening, Antimicrobial and Antioxidant Properties of the Leaf Fractions of Scoparia Dulcis Danjuma, Kabir; Kabir Abdu; Imrana Lawan; Moses Jibrin; Magaji Amayindi
Indonesian Journal of Health Research and Development Vol. 3 No. 2 (2025): Indonesian Journal of Health Research and Development (June)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/ijhrd.v3i2.422

Abstract

Background: Scoparia dulcis is a medicinal plant found in low and high temperature areas. Aims and scope: This study was done to examine the effect of solvent’s polarity on extraction yield, evaluate phytochemicals, antioxidant and antimicrobial capacity of Scoparia dulcis.Methods: Solvents of different polarities were used to fractionate the ethanol crude by maceration. Phytochemicals screening was done using standard methods, and DPPH experiment was used to screen for antioxidant capacity. Agar diffusion method was used to evaluate the leaf extracts for antimicrobial potential.Results: Methanol gives highest yield (10.73%), followed by cetone (9.56%), chloroform (6.94%), and petroleum ether (5.16%). Glycosides and anthroquinones were not found, but alkaloids, terpenoids, tannins, saponins, steroids, polyphenols, flavonoids, and reducing sugar were qualitatively detected. Scopariadulcis also showed significant antimicrobial capacity; with acetone displaying highest capacity, followed by methanol and chloroform extracts. The results also showed remarkable antimicrobial capacity with acetone exhibiting largest inhibition zone. The extracts also produced Antioxidant capacity with chloroform having highest activity (IC50 = 29.6288 µg/mL), followed by petroleum ether (IC50 = 34.5308 µg/mL), methanol (), and acetone (IC50 = 100.3340 (µg/mL). ANOVA test shows the plant extract has significant antimicrobial and antioxidant capacity at P>0.05.Conclusion: Scoparia dulcis leaf extracts contain phytochemicals that possess antimicrobial and antioxidant potentials. This research is the first of its kind carried out on this plant in northern Nigeria. The plant is a valuable medicinal plant that can be used for therapeutic applications.
PRELIMINARY QUALITATIVE PHYTOCHEMICAL SCREENINGS AND ANTIMICROBIAL POTENTIALS OF THE LEAF EXTRACTS OF MORINGA OLEIFERA GROWN IN ENUGU STATE, SOUTHEASTERN NIGERIA: THE LEAF EXTRACTS OF MORINGA OLEIFERA GROWN Danjuma, Kabir; Lawan, Imrana; Jaafar , Saleh; Abdulmajid, Shafiu
INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD) Vol. 7 No. 1 (2025): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
Publisher : STIKes Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36566/ijhsrd/Vol7.Iss1/260

Abstract

Background: Moringa oleifera, being one of the 14 species of family Moringaceae, is an herbal medication that is well-known for its many therapeutic applications. Worldwide, moringa has been used as a traditional herbal medications for a variety of conditions, including anemia, skin infections, blackheads, anxiety, bronchitis, catarrh, chest congestion, asthma, blood impurities, cholera, glandular, swelling, headaches, conjunctivitis, cough, diarrhea, eye and ear infections, fever, hysteria, joint pain, pimples, psoriasis, respiratory disorders, scurvy, semen deficiency, sore throat, sprain, tuberculosis, intestinal worms, lactation, diabetes, and pregnancy. This study was done to determine qualitatively the phytochemicals and antimicrobial potentials of the leaf extracts of moringa oleifera. Methods: Cold extraction (maceration) was used using 95 % ethanol as extracting solvent. The phytochemical screening was done using standard procedure/methods (to detect alkaloids, flavonoids, terpenoids, steroids, tannins, saponins, glycosides, and polyphenols), while antimicrobial potentials was done using disc diffusion method. The phytochemical screening showed the presence of alkaloids, terpenoids, flavonoids, tannins, saponins, polyphenols, steroids, and glycosides. Results: he results also showed that moringa was active against antibacterial (S. aureus and E. coli) and fungal (Rhizopus and A. niger) isolates tested, with petroleum ether extract showing greater activity (larger zones of inhibition), followed by methanol, acetone, and chloroform extracts, respectively Conclusion: We have concluded that Moringa oleifera can be utilized as a safe and affordable plant antimicrobial agent since it contains active components with antibacterial properties, including flavonoids, tannins, saponins, alkaloids, phenolics, and triterpenoids.
ASSESSMENT OF CYTOTOXICITY, ANTIOXIDANT AND ANTIMICROBIAL PROPERTIES OF THE LEAF EXTRACTS OF ABELMOSCHUS ESCULENTUS CULTIVATED IN NORTHERN NIGERIA: LEAF EXTRACTS OF ABELMOSCHUS ESCULENTUS Danjuma, Kabir; Abdu, Kabir; Lawan, Imrana; Amayandi, Magaji; Jibrin, Moses
INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD) Vol. 6 No. 2 (2024): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
Publisher : STIKes Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36566/ijhsrd/Vol6.Iss2/256

Abstract

Background: Okra (Abelmochus esculentus) belongs to Malvaceae family and is widely cultivated in Africa, India, America, and Brazil for its fibrous fruits containing round, white seeds. This study was carried out to assess the cytotoxicity, antioxidant and antimicrobial activities of the leaf extracts of Abelmoschus esculentus cultivated in north-western, Nigeria. Methods: The plant sample was collected, washed, identified, grounded into powder and extracted using solvent extractor with ethanol as solvent, and this was followed by fractionation using three more solvents of different polarities (starting with n-hexane, ethyl acetate, and then methanol). The cytotoxicity of the extracts was assessed using Brine Shrimp Lethality assay; Antioxidant activity of the extracts was studied using DPPH radical scavenging assay method, while antimicrobial activity was determined using agar well diffusion method. Results: The cytotoxicity results showed n-hexane having highest activity (LC50 394.499 µg/ml), followed by methanol extract (LC50 538.098 µg/ml), ethyl acetate extract (LC50 2106.499 µg/ml), and then crude extract (LC50 5634.091 µg/ml) respectively. The results also revealed that the extracts possessed significant antioxidant activity, with crude extract showing highest activity (IC50 = 74.229 µg/ml), followed by methanol extract (IC50 = 83.396 µg/ml), ethyl acetate extract (IC50 = 126.159 µg/ml), and then n-hexane extract (IC50 = 138.936 µg/ml). The extracts revealed remarkable antimicrobial activity and were even more noticeable in antibacterial result at higher concentrations with ethyl acetate extract showing largest zone of inhibitions, followed by n-hexane extract, crude extract, and then methanol extract respectively. Conclusion: From the findings of this research study we have concluded that the leaf extracts Abelmoschus esculentus possesses antimicrobial and antioxidant activities and is also less toxic.  
Comparative Phytochemicals Screening, Antibacterial and Antioxidant Properties of Some Selected Medicinal Plants in Nigeria Danjuma, Kabir
Indonesian Journal of Health Research and Development Vol. 3 No. 3 (2025): Indonesian Journal of Health Research and Development (November)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/ijhrd.v3i3.518

Abstract

Background: Antibiotics resistance poses serious health threats globally, necessitating the search and development of an efficient environmentally friendly antibiotics. Evaluation of medicinal plants possessing antioxidant and antimicrobial chemicals is essential for solving this problem and improves human health.Aims: This research was done to assess the phytochemical status, antioxidant and antibacterial potentials of the leaf extracts of four medicinal plants (Moringa oleifera, Linus usitatissimum, Vernonia amygdalina, and Anacardium occidentale) cultivated in Nigeria. Methods: Standard methods were used to screen the phytochemicals; agar well diffusion and DPPH radical scavenging assays were employed to evaluate the antibacterial and antioxidant properties of the extracts. Results: The results showed that the medicinal plants tested possessed significant phytochemicals including alkaloids, flavonoids, phenolics, terpenoids, tannins, saponins, among others. The plants showed effective antibacterial properties, with Moringa oleifera showing highest antibacterial activities against Staphylococcus aureus and Escherichia coli, followed by Vernonia amygdalina, Linus usitatissimum, and anacardium occidentale. The medicinal plants also showed powerful antioxidant potentials with lower IC50 values. moringa oleifera being the most powerful has an IC50 value of 41.95 µg/ml, followed by Linus usitatissimum (IC50 = 43.09 µg/ml), Vernonia amygdalina (IC50 = 54.64 µg/ml), and anacardium occidentale (IC50 = 66.85 µg/ml), compared with the standard ascorbic acid (IC50 = 14.14 µg/ml)). Conclusion: The medicinal plants tested in this study possess significant bioactive compounds and could serve as an effective potential agent against pathogenic bacteria, suppress oxidative stress thereby improving the human health quality.
Co-Authors Abdu, Kabir Abdulmajid, Shafiu Amayandi, Magaji Imrana Lawan Jaafar , Saleh Jibrin, Moses Kabir Abdu Lawan, Imrana Magaji Amayindi Moses Jibrin