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All Journal Agrosains: Jurnal Penelitian Agronomi Jurnal Jamu Indonesia Indonesian Journal of Jamu
Yamauchi, Kosei
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Other

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Potential of Active Compounds in Broadleaf Mahogany (Swietenia macrophylla) Seeds Against Breast Cancer Cells Based on In Silico Study Cahya, Hanifah Dwi; Nurlela, Nurlela; Tohir, Dudi; Batubara, Irmanida; Asoka, Shadila Fira; Yamauchi, Kosei
Jurnal Jamu Indonesia Vol. 9 No. 1 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i1.296

Abstract

Breast cancer is a leading cause of cancer-related deaths in Indonesia. However, the drugs that are commonly used for treatment can cause side effects and become resistant over time. A study was conducted to test the cytotoxic activity of broadleaf mahogany (Swietenia macrophylla) seed extract on MCF-7 breast cancer cells in vitro. The study aimed to predict active compounds in the broadleaf mahogany seeds that have the potential to act as anti-breast cancer agents using in silico analysis. Molecular docking, visualization of the interaction between the receptor and the ligands, and physicochemical analysis were used to determine the most promising compounds. The receptors used were fibroblast growth factor receptor 1 (FGFR1), vascular endothelial growth factor receptor 2 (VEGFR2), insulin-like growth factor type 1 receptor (IGF-1R), estrogen receptor (ER-α), and progesterone receptor (PR). The results showed that 12 compounds have the potential to be active as anti-breast cancer agents. Three of these compounds, 3β,6-dihydroxydihydrocarapine, stigmasterol, and 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chroman-4-one, were predicted to have similar mechanisms of inhibition as a comparator drug based on binding site similarity values. These compounds are predicted to be taken orally and are promising for further research.
Potential of Active Compounds in Broadleaf Mahogany (Swietenia macrophylla) Seeds Against Breast Cancer Cells Based on In Silico Study Cahya, Hanifah Dwi; Nurlela, Nurlela; Tohir, Dudi; Batubara, Irmanida; Asoka, Shadila Fira; Yamauchi, Kosei
Jurnal Jamu Indonesia Vol. 9 No. 1 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i1.296

Abstract

Breast cancer is a leading cause of cancer-related deaths in Indonesia. However, the drugs that are commonly used for treatment can cause side effects and become resistant over time. A study was conducted to test the cytotoxic activity of broadleaf mahogany (Swietenia macrophylla) seed extract on MCF-7 breast cancer cells in vitro. The study aimed to predict active compounds in the broadleaf mahogany seeds that have the potential to act as anti-breast cancer agents using in silico analysis. Molecular docking, visualization of the interaction between the receptor and the ligands, and physicochemical analysis were used to determine the most promising compounds. The receptors used were fibroblast growth factor receptor 1 (FGFR1), vascular endothelial growth factor receptor 2 (VEGFR2), insulin-like growth factor type 1 receptor (IGF-1R), estrogen receptor (ER-α), and progesterone receptor (PR). The results showed that 12 compounds have the potential to be active as anti-breast cancer agents. Three of these compounds, 3β,6-dihydroxydihydrocarapine, stigmasterol, and 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chroman-4-one, were predicted to have similar mechanisms of inhibition as a comparator drug based on binding site similarity values. These compounds are predicted to be taken orally and are promising for further research.
Effect of Kinetin and 2,4-D Plant Growth Regulators on In Vitro Subculture Growth of Dendrobium stockelbuschii Talitha, Okky; Yamauchi, Kosei; Setyawati, Andriyana; Iqbal, Muhammad; Saskya, Nanda
Agrosains : Jurnal Penelitian Agronomi Vol 27, No 2 (2025): Agrosains: Jurnal Penelitian Agronomi
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/agsjpa.v27i2.110517

Abstract

Dendrobium orchids are a popular genus due to their adaptability and wide variation in flower shapes and colors. Conventional propagation methods face challenges in producing large quantities of high-quality seedlings. This study aimed to produce superior-quality seedlings through tissue culture techniques using ½ Murashige and Skoog (MS) medium supplemented with kinetin and 2,4-D to enhance growth. The research was conducted at the Plant Physiology and Biotechnology Laboratory, Sebelas Maret University, from February to July 2024. The experimental design used was a completely randomized design (CRD) with two factors. The first factor was kinetin concentration (0, 0.5, 1, 1.5, 2 ppm), and the second factor was 2,4-D concentration (0, 0.5, 1, 1.5, 2 ppm). A total of 25 treatment combinations were tested, each replicated three times, resulting in 75 experimental units. Observed parameters included the number of roots, plant height, number of shoots, and root length. Data were analyzed using analysis of variance (ANOVA) at a 5% significance level, followed by Duncan’s Multiple Range Test (DMRT) for mean separation. The results showed that kinetin had a significant effect on the number of roots and plant height, while 2,4-D significantly affected root length. No significant interaction was observed between the two factors.
Co-Authors Asoka, Shadila Fira Cahya, Hanifah Dwi Irmanida Batubara Muhammad Iqbal Nurlela Nurlela Saskya, Nanda Setyawati, Andriyana Talitha, Okky Tohir, Dudi