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All Journal Sains Natural: Journal of Biology and Chemistry Journal of Multidisciplinary Science: MIKAILALSYS
Fajri Ikhsan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Physics Social Sciences Other

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Interaction of Coumarin, Daphnetin, Fraxetin from Natural Materials with Carbanoic anhydrase II in Inhibiting Glaucoma Rismi Verawati; Fajri Ikhsan; Okta Suryani
Sains Natural: Journal of Biology and Chemistry Vol. 14 No. 4 (2024): Sains Natural
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31938/jsn.v14i4.735

Abstract

This article explores the interaction of Coumarin compounds and their derivatives obtained from natural extracts with Carbonic anhydrase II protein in inhibiting Glaucoma computationally. This research method includes modeling using software such as Pymol, Pyrx, Protein Plus, and Lipinski Rule of Five. The results showed Binding Affinity and RMSD of Coumarin, Daphnetin, and Fraxetin compounds with Carbonic anhydrase II with strong interaction. Protein Plus analysis was used to visualize the interaction that occurred between the compound and the Carbonic anhydrase II protein, in addition to the Lipinski Rule of Five test results, which showed results that were in accordance with the rules and met the drug criteria. These results indicate that Coumarin, Daphnetin, and Fraxetin compounds as Carbonic anhydrase II inhibitors have the potential to inhibit glaucoma. Daphnetin compound is the best inhibitor seen from the Binding Affinity value of -6.9, -5.8, and -5.5, as well as the results of Daphnetin's Lipinski Rule of Five data. However, further research is needed to validate this computational study.
Synthesis and Characterization of ZnO-Doped CuO with the Addition of Monoethanolamine Using the Sol-Gel Method Nazellia Asnur; Hary Sanjaya; Indang Dewata; Fajri Ikhsan
Journal of Multidisciplinary Science: MIKAILALSYS Vol 4 No 1 (2026): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v4i1.9537

Abstract

Semiconductors are materials capable of conducting electricity within specific limits, a property that is essential for applications in photocatalysts and solar cells. Copper oxide (CuO), a transition metal oxide, exhibits favorable properties as a p-type semiconductor and is characterized by a narrow bandgap ranging from 1.2 to 1.8 eV. However, CuO has a limitation in the form of a high electron–hole recombination rate, which requires modification through doping and additive incorporation. This study aims to analyze the effects of zinc oxide (ZnO) doping and the addition of monoethanolamine (MEA) on the characteristics of CuO nanoparticles synthesized using the sol–gel method. This method was selected because it can produce materials with a large surface area and good stability. Characterization was conducted using ultraviolet–diffuse reflectance spectroscopy (UV–DRS) to determine bandgap energy. The findings show that the optimal bandgap value was obtained at 20% ZnO concentration, with a bandgap energy of 1.33 eV, while the addition of 2 mL MEA produced a bandgap energy of 1.42 eV. The decrease in bandgap value indicates that ZnO doping affects the optical properties of CuO. A smaller bandgap narrows the distance between the valence band and the conduction band, thereby facilitating electron excitation and requiring lower photon energy. This study contributes to the development of modified CuO-based semiconductor materials by demonstrating the potential role of ZnO doping and MEA addition in improving optical characteristics relevant to photocatalytic and solar cell applications.
Co-Authors Hary Sanjaya Indang Dewata Nazellia Asnur Rismi Verawati Suryani, Okta