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All Journal Muhammadiyah Medical Journal
Wiratmoko, Raden Mirsyam Ratri
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Correlation between Interleukin-6 with D-dimer and C-reactive protein Levels in Patients with Confirmed COVID-19 Severe Criteria Gemintang, Ghea Setia; Wiratmoko, Raden Mirsyam Ratri; Tubarad, Gladys Dwiani Tinovella
Muhammadiyah Medical Journal Vol 5, No 2 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.2.69-75

Abstract

Background: In Coronavirus Disease 2019 (COVID-19) severe criteria, cytokine storm conditions are often found, and there will be an increase in Interleukin-6 as a cytokine and CRP as an acute phase protein induced by IL-6. In COVID-19 patients with severe criteria, coagulation disorders can also be found, characterized by an increase in the D-dimer value. Purpose: To determine the correlation between IL-6, D-dimer, and CRP levels in patients with confirmed COVID-19 severe criteria at Bunda Margonda General Hospital in 2021. Methods: This research was an analytical observation study with a cross-sectional approach, using secondary data from medical records of patients with confirmed COVID-19 severe criteria at Bunda Margonda General Hospital in 2021. Results: The number of patients with confirmed COVID-19 severe criteria was primarily male (59%), aged 46-55 years (33%), with degree of severity with severe criteria in 100 patients, increased IL-6 (91%), increased D-dimer levels (90%), increased CRP levels (95%). There was a correlation between increased IL-6 with D-dimer levels (p-value 0,005) and a correlation between increased IL-6 with CRP levels (p-value of 0,000). A simultaneous and significant relationship was found between IL-6, D-dimer, and CRP levels in severe COVID-19 criteria. COVID-19 patients with severe criteria were more commonly found in males in the 46-55-year age group with increased IL-6, D-dimer, and CRP values. Conclusion: There was a correlation between increased IL-6 and D-dimer and CRP levels in COVID-19 patients with severe criteria at Bunda Margonda General Hospital in 2021.
Comparison of Treatment Duration for Drug-Sensitive Tuberculosis in Patients With and Without HIV Infection Fachri, Muhammad; Ardhia, Farrah Salsabilla; Wiratmoko, Raden Mirsyam Ratri; Ardhia, Faisal Irsyad
Muhammadiyah Medical Journal Vol. 7 No. 1 (2026): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.7.1.8-14

Abstract

Background: Indonesia had 842,000 new TB cases and 116,400 TB deaths in 2018, including TB-HIV cases. TB-HIV co-infection remains a major health concern. Objective: To compare the duration of treatment of drug-sensitive tuberculosis in patients with and without HIV at Jakarta Cempaka Putih Islamic Hospital, Jakarta Sukapura Islamic Hospital, and Jakarta Pondok Kopi Islamic Hospital for the period September 2022 to September 2024. Methods: A cross-sectional study with a total sampling technique was conducted on 82 patients. The analysis used an independent T-test to compare treatment duration. Results: Of the 105 patients, 15 had drug-sensitive tuberculosis with HIV and 90 without HIV. The majority of patients were men (66 samples), with the largest age group being 35-44 years old. No significant difference in treatment duration was found between drug-sensitive tuberculosis patients with and without HIV (p= 0.569). Conclusions: Comparison of the duration of treatment for drug-sensitive TB patients with and without HIV was the same, and there was no significant difference.
Co-Authors Ardhia, Faisal Irsyad Ardhia, Farrah Salsabilla Gemintang, Ghea Setia Muhammad Fachri Tubarad, Gladys Dwiani Tinovella