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All Journal Althea Medical Journal Indonesian Journal of Obstetrics & Gynecology Science
Grazielle, Grazielle
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Health Professions Medicine & Pharmacology Public Health

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Characteristics of Extraneural Tuberculosis in Patients with Tuberculous Meningitis Hospitalized at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia in 2017–2021 Grazielle, Grazielle; Ganiem, Ahmad Rizal; Sobaryati, Sobaryati; Dian, Sofiati; Santoso, Prayudi
Althea Medical Journal Vol 11, No 4 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n4.3205

Abstract

Background: Tuberculous (TB) meningitis is the most severe manifestation of extrapulmonary TB and contributes to a high mortality rate. The presence of extraneural TB may raise suspicion of TB meningitis (TBM). This study aimed to explore the characteristics of extraneural TB in TBM patients.Methods: This was a cross-sectional descriptive study using secondary data from medical records of TBM patients admitted at Dr. Hasan Sadikin General Hospital Bandung, Indonesia from 2017 to 2021. Demographic and clinical data were collected, including HIV status. TBM cases were classified into grades I, II, and III using Medical Research Counsil (MRC) criteria that were based on Glasgow Coma Scale (GCS) score and the presence of focal neurological deficits. The clinical classification diagnosis of TBM was made based on the Marais diagnostic criteria which included several diagnostic items and corresponding scoring which further divides TBM into three classes. Extraneural TB is defined as the finding of TB outside the nervous system. Disseminated TB was diagnosed based on the finding of ≥2 infected locations.Results: During the study period, 497 medical records were analyzed. Most TBM patients experienced Grade II (76.9%) and extraneural TB site was found in 65.4%, with pulmonary TB as the common site (77%). The highest mortality rate was in disseminated TB (50%). The finding of extraneural TB did not differ between HIV-negative and HIV-positive patients (67.8% vs. 67.9%; p=0.101).Conclusion:  The presence of extraneural TB is common in patients with TBM. Therefore, extraneural TB evaluation is important to ensure TBM diagnosis. Further studies are needed to explore factors related to TBM diagnosis to ensure TBM patient’s wellbeing.
Correlation of Histological Type, Stage, Age, and Prognosis in Uterine Cervical Cancer at Margono Soekardjo Hospital Purwokerto from January – December 2024 Tambunan, Eka Maranatha; Permadi, Wiryawan; Aditiyono, Aditiyono; Grazielle, Grazielle
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.1007

Abstract

Objective: To evaluate the correlation of histological subtype, stage, age, and prognosis in cervical cancer patients treated at Prof. Dr. Margono Soekarjo Hospital, Purwokerto.Methods: This is a retrospective descriptive cohort study conducted using medical records. Data on cervical cancer staging, age, and histopathological subtype were collected from all patients meeting the inclusion criteria. Statistical analysis was performed, and associations were examined using chi-square tests. The data used in the study were obtained from the medical records of patients at the research site from January to December 2024.Result: Of 582 patients identified, 245 met the inclusion criteria. Squamous cell carcinoma (SCC) accounted for 147 cases, and adenocarcinoma (AC) for 98. Most patients were aged >50 years old and diagnosed at stage II. SCC was most common at stage II, while AC was most frequently found at stage III. Statistical analysis revealed a significant but weak association between age, stage, prognosis, and histological subtype.Conclusion: There was a significant weak correlation of histological subtype and age, stage, and prognosis in cervical cancer.Korelasi Tipe Histologis, Stadium, Usia, dan Prognosis pada Kanker Uterin Serviks di Rumah Sakit Margono Soekardjo pada Januari – Desember 2024AbstrakTujuan: Penelitian ini bertujuan untuk mengetahui korelasi antara subtipe histologis, stadium, usia, dan prognosis kanker serviks uteri pada pasien yang diobati di RSUD Prof. Dr. Soekarjo Margono, Purwokerto, dalam rentang waktu Januari – Desember 2024Metode: Studi ini merupakan studi retrospektif deskriptif kohort dengan data dari rekam medis. Data yang diambil adalah stadium kanker, usia, dan subtipe histopatologis dan didapatkan dari semua pasien yang memenuhi kriteria inklusi. Analisis statistik dilakukan serta asosiasi diuji dengan uji Chi-Square. Data yang digunakan dalam penelitian diperoleh dari rekam medis pasien di RSUD Margono Soekardjo, Purwokerto pada bulan Januari hingga Desember 2024Hasil: Dari 582 pasien, sebanyak 245 pasien memenuhi kriteria inklusi. Karsinoma sel skuamosa (SCC) ditemukan pada 147 kasus, sedangkan adenokarsinoma (AC) pada 98 kasus. Sebagian besar pasien berusia >50 tahun dan didiagnosis pada stadium II. SCC paling banyak ditemukan pada stadium II, sementara AC didapatkan paling banyak pada stadium III. Analisis statistik menunjukkan adanya hubungan bermakna dengan korelasi lemah antara usia, stadium, dan prognosis dengan tipe histologis.Kesimpulan: Terdapat korelasi signifikan antara subtipe histologis dan usia, stadium, serta prognosis kanker serviks.Kata kunci: Kanker serviks; prognosis; subtipe histologis; stadium; usia
Co-Authors Aditiyono, Aditiyono Ahmad Rizal Ganiem, Ahmad Rizal Prayudi Santoso Sobaryati, Sobaryati Sofiati Dian Tambunan, Eka Maranatha Wiryawan Permadi