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All Journal Jurnal Riset Farmasi Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran
Rakha Widyastama
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Chemistry Health Professions Medicine & Pharmacology Public Health

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Perbandingan Polimer pada Tablet Bukal dan Pengaruhnya pada Penghantaran Muhammad Fathur Rahman; Rakha Widyastama; Padma Azzahra Ramadhani; Elita rahmah; Zalmi, Zalmiati; Nor Latifah
Jurnal Riset Farmasi Volume 4, No. 2, Desember 2024, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v4i2.5443

Abstract

Abstract.The development of mucoadhesive buccal films has become a focus of pharmaceutical research to improve oral drug delivery. The combination of polymers such as carbopol and HPMC improves film adhesion, while variations in excipients influence physical properties and drug release. The ideal film should be flexible, have a neutral pH, and be able to release the drug in a controlled manner. Although progress has been made, further research is needed for in vivo evaluation and addressing challenges such as interindividual variability. With great potential, mucoadhesive buccal films can be an attractive alternative for oral drug delivery. Abstrak. Pengembangan film bukal mukoadhesif menjadi fokus penelitian farmasi untuk meningkatkan penghantaran obat oral. Kombinasi polimer seperti karbopol dan HPMC meningkatkan adhesi film, sedangkan variasi eksipien memengaruhi sifat fisik dan pelepasan obat. Film yang ideal harus fleksibel, memiliki pH netral, dan dapat melepaskan obat secara terkontrol. Meskipun kemajuan telah dicapai, penelitian lebih lanjut diperlukan untuk evaluasi in vivo dan mengatasi tantangan seperti variabilitas antar individu. Dengan potensi yang besar, film bukal mukoadhesif dapat menjadi alternatif menarik untuk penghantaran obat oral.
Review Jurnal : Perbandingan Uji Stabilitas Paracetamol dan Asetosal dalam Sediaan Tablet Rakha Widyastama; Sri Tami Dewi; Nor Latifah
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 2 No. 3 (2025): Juli: Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v2i3.1937

Abstract

Drug stability testing is a critical aspect in the development and storage of pharmaceutical preparations to ensure the safety, quality, and efficacy of the product throughout its shelf life. Drug stability is influenced by various intrinsic and extrinsic factors, such as temperature, humidity, light, pH, and chemical and physical interactions. Stability evaluation includes long-term stability testing, accelerated stability, and in-use stability testing in accordance with ICH, WHO, or FDA guidelines. Parameters assessed include the potency of the active substance, degradant levels, physicochemical properties, and microbiological characteristics. The results of stability studies are used to determine shelf life, storage recommendations, and appropriate packaging. A thorough understanding of drug stability is essential in the pharmaceutical industry to ensure regulatory compliance and protect patient health.
Co-Authors Elita rahmah Muhammad Fathur Rahman Nor Latifah Padma Azzahra Ramadhani Sri Tami Dewi Zalmi, Zalmiati