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CSF Biofire-assisted Rapid Diagnosis of a Case of Cryptococcal Meningoen-cephalitis: A Case Report Arora, Ekal; Dhamija , Sakshi; Garg , Prachi; Arora , Sonalika; Prakash , Jai; Dangi , Anoop; Arya , Gaurav
Clinical and Research Journal in Internal Medicine Vol. 5 No. 2 (2024): Volume 5 No 2, November 2024
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2024.005.02.14

Abstract

Cryptococcosis causes invasive fungal infections and the two common species are cryptococcus neoformans and cryptococcus gattii, which are responsible for the majority of the clinical manifestations. We are presenting a case of a 35-year-old individual who was admitted with the complaints of fever associated with acute onset altered sensorium. His CSF PCR testing showed cryptococcus species, and so diagnosed as cryptococcal meningoencephalitis and then eventually found to have HIV/AIDS. CSF PCR testing can be done rapidly for variety of common bacterial and fungal infections, and its results are available within one hour. The early diagnosis and treatment initiation is very vital in immunodeficiency states such as HIV, as it can have positive prognostic effect on natural course of disease process. The patient did receive dual anti-fungal drugs, along with Antiretroviral therapy (ARV) and showed drastic clinical improvement.
Prevalence, Antibiotics Sensitivity & Resistance Pattern of Staphylococcus Aureus in Urinary Tract Infections-an experience from semi-urban community of India. Dhamija, Sakshi; Hora, Shilpi; Arora, Ekal; Arora, Sonalika
Clinical and Research Journal in Internal Medicine Vol. 6 No. 2 (2025): Volume 6 No 2, November 2025
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2025.006.02.03

Abstract

Background: The urinary tract infections (UTIs) are one of the commonest infections, leading to health centre visits worldwide and in India. Staphylococcus aureus, initially was a lesser-known cause of urinary tract infection, though incidence and prevalence are rising with time and so did the use of antibiotics to treat these infections. The antibiotics pattern to treat these infections too have changed overtime due to both host and pathogen evolutionary variations. Aim: We have therefore conducted a retrospective hospital-based study, at Jhalawar Medical college, Rajasthan, India in order to understand the antibiotic sensitivity and resistance pattern of staphylococcus aureus strain, currently prevailing in our area and also calculated its prevalence in patients suffering from urinary tract infections. Material & Methods: The Mid-stream urine samples were collected from the patients using aseptic techniques, and culture and sensitivity was done using standard microbiological methods like disc diffusion and broth dilution techniques. The sensitivity pattern of staphylococcus aureus was recorded among the positive urine culture samples. Results: In our study, a total of 2703 patients urine cultures were included, and out of these 296 (10.95%) samples grew some Uro-pathogens. Out of these 296 urine cultures, 48 (16.21%) were positive for staphylococcus aureus. From these 48, there were 2 (4.16%), strains, found to have vancomycin resistance. The methicillin resistant staphylococcus aureus was found in 3 (6.25%) of urine culture samples. Conclusion: The staphylococcus aures strain, that was found resistant to five or more antibiotics were labelled as multi drug resistant pathogen. Commonly used antibiotics like cotrimoxazole, gentamycin, norfloxacin, cephalexin, ciprofloxacin, showed resistance to treat this staphylococcus aureus strain. Due to rising resistant strains, we need to devise new antibiotics use strategy and modes to conquer this challenge. Keywords- Staphylococcus aureus, Antibiotic Sensitivity, Resistance pattern, Semi-Urban, UTI