<![CDATA[Background: The urinary tract infections (UTIs) are one of the commonest infections, leading to health centre visits worldwide and in India. Staphylococcus aureus, initially was a lesser-known cause of urinary tract infection, though incidence and prevalence are rising with time and so did the use of antibiotics to treat these infections. The antibiotics pattern to treat these infections too have changed overtime due to both host and pathogen evolutionary variations. Aim: We have therefore conducted a retrospective hospital-based study, at Jhalawar Medical college, Rajasthan, India in order to understand the antibiotic sensitivity and resistance pattern of staphylococcus aureus strain, currently prevailing in our area and also calculated its prevalence in patients suffering from urinary tract infections. Material & Methods: The Mid-stream urine samples were collected from the patients using aseptic techniques, and culture and sensitivity was done using standard microbiological methods like disc diffusion and broth dilution techniques. The sensitivity pattern of staphylococcus aureus was recorded among the positive urine culture samples. Results: In our study, a total of 2703 patients urine cultures were included, and out of these 296 (10.95%) samples grew some Uro-pathogens. Out of these 296 urine cultures, 48 (16.21%) were positive for staphylococcus aureus. From these 48, there were 2 (4.16%), strains, found to have vancomycin resistance. The methicillin resistant staphylococcus aureus was found in 3 (6.25%) of urine culture samples. Conclusion: The staphylococcus aures strain, that was found resistant to five or more antibiotics were labelled as multi drug resistant pathogen. Commonly used antibiotics like cotrimoxazole, gentamycin, norfloxacin, cephalexin, ciprofloxacin, showed resistance to treat this staphylococcus aureus strain. Due to rising resistant strains, we need to devise new antibiotics use strategy and modes to conquer this challenge. Keywords- Staphylococcus aureus, Antibiotic Sensitivity, Resistance pattern, Semi-Urban, UTI]]>
