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All Journal Indonesian Journal of Cancer Chemoprevention Journal of Islamic Medicine
Halim, Putri Aulawiya Rosyida
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Successful Intravitreal Injection of Ranibizumab for Age-Related Macular Degeneration (AMD) in Young Adults: A Case Report Adnani, Basyar; Sumarta, Norma Hanifah; Famuji, Siti Roziah Ria; Khotimah, Alif Raudhah Husnul; Halim, Putri Aulawiya Rosyida; Hasan, Yuliono Trika Nur; Hutasoit, Lina Puspita
Journal of Islamic Medicine Vol 8, No 1 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i1.25838

Abstract

Background:  Age Related Macular Degeneration (AMD) is a chronic condition that specifically affects the central retina and is widespread in developed nations. The hypothesis suggests that as the population ages, the occurrence and impact of AMD will rise due to the significant risk factor of being over 55 years old, which is most prevalent among the elderly. Bevacizumab, ranibizumab, and aflibercept have established themselves as the gold standard of therapy. Case Report:  We present the case of a middle-aged man with age-related macular degeneration (AMD) and no concomitant diseases who showed remarkable improvement after intravitreal injection with patizra (ranibizumab). A 44-year-old Asian man was administered Patizra injections for three consecutive months after developing age-related macular degeneration. After intravitreal injection of ranibizumab, this patient's health markedly improved, as seen by a reduction in subretinal fluid. Conclusion:  The intravitreal injection of ranibizumab has demonstrated efficacy in the treatment of age-related macular degeneration in middle-aged adults.
Potential Inhibition of Melaleuca leucadendron L. Compounds Against the NSP5 SARS CoV-2 Protein Melani, Ira Resmi; Wafi, Muhammad Farid; Riandinata, Mohammad Reza; Halim, Putri Aulawiya Rosyida; Muti'ah, Roihatul; Santosaningsih, Dewi
Indonesian Journal of Cancer Chemoprevention Vol 13, No 3 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss3pp195-206

Abstract

COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome (SARS-CoV-2), causing a global health emergency as a pandemic disease. The lack of certain drug molecules or treatment strategies to fight this disease makes it worse. Therefore, effective drug molecules are needed to fight COVID-19. Non Structural Protein (NSP5) or called Main Protease (Mpro) of SARS CoV 2, a key component of this viral replication, is considered a key target for anti-COVID-19 drug development. The purpose of this study is to determine whether the compounds in the Melaleuca leucadendron L. plant such as 1,8-cineole, terpene, guaiol, linalol, α-selinenol, β-eudesmol and γ-eudesmol are predicted to have antiviral activity for COVID-19. Interaction of compounds with NSP5 with PDB code 6WNP analyzed using molecular docking with Molegro Virtual Docker. Based on binding affinity, the highest potential as an anti-viral is Terpineol with binding energy (-119.743 kcal/mol). The results of the interaction showed that terpinol has similarities in all three amino acid residues namely Cys 145, Gly 143, and Glu 166 with remdesivir and native ligand. Melaleuca leucadendron L. may represent a potential herbal treatment to act as: COVID-19 NSP5, however these findings must be validated in vitro and in vivo.Keywords: COVID-19, In Silico, NSP5/ 6WNP, Melaleuca leucadendron L.
Co-Authors Adnani, Basyar Dewi Santosaningsih Famuji, Siti Roziah Ria Hutasoit, Lina Puspita Khotimah, Alif Raudhah Husnul Melani, Ira Resmi Muti'ah, Roihatul Riandinata, Mohammad Reza Sumarta, Norma Hanifah Wafi, Muhammad Farid Yuliono Trika Nur Hasan