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All Journal Media Farmasi
Dirgahayu Yahya, Nurul Fitri
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Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Peningkatan Kelarutan Ketoprofen Dalam Bentuk Mikropartikel Dengan Metode Emulsification-Ionic-Gelation Menggunakan Polyvinylprrolidone (PVP) Dan Tripolifosfat(TPP) Dirgahayu Yahya, Nurul Fitri; Sinala, Santi; Stevani, Hendra
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.1006

Abstract

A nonsteroidal anti-inflammatory drug called ketoprofen is used to treat musculoskeletal and joint disorders, including osteoarthritis. Ketoprofen has a low solubility in water, which is a major obstacle to the absorption of the drug into the body.However, by using emulsification ion gelation technology, it is possible to create microparticles, which can improve the solubility of ketoprofen. . The aim of this study was to use emulsification and ion gelation to produce ketoprofen microparticles with higher solubility. SEM was used to characterize the structure of the ketoprofen particles. Subsequently, ketoprofen solubility and content tests were performed. When the properties were evaluated using SEM microparticles, the particle size gradually decreased from pH2, pH4, and pH6, and the water solubility of the drug increased due to the small particle size of the generated microparticles. After the emulsification-ionic gelation process, the solubility of ketoprofen increased two-fold and the pH of water increased two-fold compared to untreated ketoprofen. From this, it can be concluded that polyvinylpyrrolidone (PVP) and tripolyphosphoric acid (TPP) effectively improved the solubility of sparingly water-soluble ketoprofen in the emulsification ion gelation process of ketoprofen production.
Optimasi Formula Foot Spray Gel Minyak Atsiri Bunga Lavender Dengan Variasi Konsentrasi Carbopol 940 Sebagai Gelling Agent Dirgahayu Yahya, Nurul Fitri; Asri SR, Muhammad; SR, Nurqalbi; Suryanita
Media Farmasi Vol 21 No 2 (2025): Media Farmasi Edisi Oktober 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i2.1666

Abstract

ABSTRACT Foot odor is a prevalent issue resulting from excessive perspiration and bacterial proliferation in moist environments. This research aimed to optimize the formulation of a lavender (Lavandula angustifolia Miller.) essential oil foot spray gel by varying the concentration of Carbopol 940 as a gelling agent. In this laboratory-based experimental study, three formulations were developed containing 0.3%, 0.5%, and 0.7% Carbopol 940. Evaluations involved organoleptic assessment, homogeneity, pH measurement, viscosity testing, spreadability, adhesion, and stability evaluation through cycling tests. All formulations fell within the skin’s pH range (4.5–6.5) and demonstrated good homogeneity. Findings indicated that higher Carbopol 940 concentrations increased viscosity while reducing spreadability. The 0.5% Carbopol 940 formulation provided the optimal balance between viscosity, spreadability, and physical stability. Cycling test results confirmed that this formulation remained stable without notable changes in physical characteristics. It is concluded that the optimal lavender essential oil foot spray gel formulation was achieved at a Carbopol 940 concentration of 0.5%. Keywords: Carbopol 940, foot spray gel, lavender, essential oil
Co-Authors Asri SR, Muhammad Hendra Stevani Sinala, Santi SR, Nurqalbi Suryanita