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All Journal Narra J IJRETINA - International Journal of Retina SCIENTIA JOURNAL : Jurnal Ilmiah Mahasiswa
Yuniasih, Kristina
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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HOMA-IR value in predicting retinal microvascular dysfunction Prayitnaningsih, Seskoati; Yuniasih, Kristina; Kautsarani, Intan; Hamid, Aulia A.; Iskandar, Agustin
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1732

Abstract

Obesity and retinal microvasculature dysfunction are linked and impact visual acuity. The aim of this study was to determine the relationship between the HOMA-IR score and the presence of vascular dysfunction (perfusion index and flux index) of the optic nerve head (ONH) of the retina in obese patients and to determine its diagnostic performance to predict vascular dysfunction. A case-control study was conducted in 2022 involving individuals from obese and non-obese groups. Insulin resistance was measured using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score using the levels of insulin and fasting glucose. Optical coherence tomography angiography (OCT-A) was performed to evaluate the flux index and capillary perfusion of ONH. The correlation between HOMA-IR, flux index, and capillary perfusion was assessed using Pearson’s correlation, and the diagnostic performance of HOMA-IR, including sensitivity, specificity, and the area under the curve (AUC), was measured. Logistic regression was used to identify the association between the HOMA-IR cutoff score with the presence of retinal microvascular dysfunction. A total of 80 individuals were included from each obese and non-obese group. The HOMA-IR score showed significant negative correlations with the perfusion of the superior (p<0.001), inferior (p<0.001), and outer (p=0.008) regions of the retinal of ONH. For the flux index, the HOMA-IR score had significant negative correlations with the superior (p=0.001), inferior (p<0.001), nasal (p=0.003), and outer (p=0.035) regions of ONH of the retina. The receiver operating characteristic (ROC) curve analysis for the HOMA-IR score at a cutoff value of 5.51 demonstrated an area under the curve (AUC) of 0.819, with a 95% confidence interval (CI) ranging from 0.727 to 0.912, suggesting its effectiveness in detecting vascular dysfunction. Multivariate logistic regression revealed a significant association between the HOMA-IR cutoff score of 5.51 with capillary perfusion of the superior (p=0.005) and nasal region (p=0.043), as well as the flux index of the inferior (p=0.013) and outer (p=0.022) regions of the ONH. These findings suggest that HOMA-IR is a promising biomarker for predicting retinal microvascular dysfunction in obese patients.
PENGARUH MODAL AWAL, LAMA USAHA DAN JENIS DAGANGAN TERHADAP PENDAPATAN PEDAGANG DI PASAR TOS 3000 BATAM Yuniasih, Kristina; Hikmah, Hikmah
SCIENTIA JOURNAL Vol 3 No 2 (2021): Volume 3 Nomor 2 2021
Publisher : LPPM Universitas Putera Batam

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Abstract

Market is a place where traders meet buyers, which will occur the sales and buying process. Income is influenced by several factors, namely initial capital, length of business and type of business. This research aims to determine the effect of initial capital, length of business and type of trade on trading income in the Tos 3000 Batam market, either simultaneous or partially. The population and sample in this research is traders in the Tos 3000 Batam market. The technique or data collection is using a questionnaire, the method of analysis in this research is uses multiple linear regression analysis hypothesis using the T and F test by SPSS application version 25. The results of this research indicate that simultaneous and partially initial capital, length of business and type of trade have a positive and significant effect on the income of traders in Tos 3000 Batam market.
DIAGNOSTIC AND THERAPEUTIC CHALLENGES OF POSTERIOR SCLERITIS MIMICKING CHOROIDAL MELANOMA yuniasih, kristina; Dewi, Nadia Artha; Sofia, Ovi
International Journal of Retina Vol 7 No 1 (2024): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2024.vol007.iss001.256

Abstract

Co-Authors Agustin Iskandar Hamid, Aulia A. Hikmah Hikmah Kautsarani, Intan Nadia Artha Dewi Seskoati Prayitnaningsih Sofia, Ovi