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All Journal Jurnal Kedokteran Brawijaya MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Majalah Kesehatan FKUB Journals of Ners Community Narra J Malang Respiratory Journal Journal of Pain, Vertigo and Headache
Seskoati Prayitnaningsih
Department Of Ophthalmology, Faculty Of Medicine Universitas Brawijaya, Saiful Anwar General Hospital, Malang, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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PERBANDINGAN ANTARA PEMBERIAN ASAM FOLAT, EKSTRAK GINKGO BILOBA, DAN METHYL COBALAMIN TERHADAP INDEKS APOPTOSIS DAN EKSPRESI CASPASE 3 PADA INTOKSIKASI METANOL SEL GANGLION RETINA Prayitnaningsih, Seskoati; Sumarno, Sumarno
Jurnal Kedokteran Brawijaya Vol 21, No 2 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (127.711 KB) | DOI: 10.21776/ub.jkb.2005.021.02.5

Abstract

ABSTRACT Permanent  visual  damage  caused  by  methanol  intoxication  has  been  associated  with  prolonged  exposures  to  blood formate  concentrations.  Formate  accumulation  disrupt  mitochondrial  energy  production,  which  subsequently  lead  to caspase 9, 3 activation and finally causes apoptosis.  Folic acid (FA) has been used as adjunctive therapy to enhance the rate  of  formate  metabolism.  Extract  Ginkgo  biloba  (EGb)  the  most  popular  herbal  therapy  possess  is  antioxidant  and antiapoptotic capacity. On the other hand, Methyl cobalamin, a kind of endogenous co enzyme B 12 can promote nucleic acid and protein synthesis. To compare the effect of FA, (EGb), and Methyl Cobalamin (MC) to Apoptotic Index (AI) and Caspase 3 expression of  retinal ganglion cell induced by methanol intoxication (MI). Experimental study was conducted in Pharmacology and Biomedic laboratory of Brawijaya University for two weeks. Fifteen rats were included, and divided into five groups: (a) control, (b) Methanol Intoxication only, (c) Folic Acid 1 mg day per os, (d) Extract Ginkgo biloba 50 mg/kb  per  os,  and  (e)  Methyl  Cobalamin  500  microgram/kg  intraperitoneally  for  three  days.  MI  were  done  by  giving methanol 4 g/kg in the first day, and 2 g/kg for two days after. Apoptotic Index and Caspase 3 expression were assessed
Perbandingan Efek Ranitidin, Dexametason dan Kombinasinya terhadap Kadar Asam Format Darah dan Pelepasan Sitokrom C Retina pada Model Tikus Intoksikasi Metanol Akut Halisa, Syahira; Prayitnaningsih, Seskoati
Jurnal Kedokteran Brawijaya Vol 26, No 3 (2011)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (735.92 KB) | DOI: 10.21776/ub.jkb.2011.026.03.8

Abstract

Keracunan metanol dapat menyebabkan toksisitas visual. Asam format merupakan metabolit yang bertanggung jawab terhadap terjadinya asidosis metabolik dan toksisitas visual yang menyebabkan kerusakan mitokondria dengan petanda penting pelepasan sitokrom C. Penelitian ini dilakukan untuk mengetahui pengaruh ranitidin dan perbedaannya dengan dexametason serta kombinasinya terhadap kadar asam format darah dan pelepasan sitokrom C retina tikus coba yang diinduksi metanol akut melalui penelitian eksperimental dengan desain post only with control. Hewan coba tikus Stratus Novergicus strain  Wistar  dibagi  dalam  lima  kelompok  dengan  7  kali  pengulangan  yaitu  kontrol negatif  dan positif ,  dan tiga kelompok  perlakuan  dengan  pemberian  ranitidin,  dexametason  dan  kombinasinya  secara  intraperitoneal.  Dilakukan pengukuran  kadar  asam  format  dengan  metode  kolorimetrik  pada  sampel  serum  darah  dan  pelepasan  sitokrom  C,  analisa data  menggunakan  One Way  ANOVA  dengan  post  hoc  test.  Hasil menunjukkan  rerata  kadar  asam  lebih  tinggi  format  pada tikus  dengan  intoksikasi  methanol  (10.441,8  ng/mL)  dibandingkan  pada  kondisi  normal  (3.612,6  ng/mL).  Pemberian ranitidin menghasilkan kadar asam format yang paling rendah (2.341,6 ng/mL) dibandingkan pemberian dexametason (5.919,2  ng/mL)  atau  kombinasi  keduanya  (2.913,2  ng/mL).
Perbandingan Sensitivitas Kontras Lensa Tanam Asferik dan Sferik Post Fakoemulsifikasi Nguda, Helen; Sulistya, T Budi; Prayitnaningsih, Seskoati
Jurnal Kedokteran Brawijaya Vol 28, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2014.028.01.10

Abstract

Lensa tanam asferik dapat mengurangi aberasi sferik yang terjadi pasca operasi katarak, dan meningkatkan sensitivitas kontras dibandingkan lensa tanam sferik. Penelitian ini membandingkan sensitivitas kontras antara pasien yang diberi lensa tanam asferik dan sferik dengan menggunakan lembar kartu Pelli-Robson yang telah dilakukan dengan metode observasi cross sectional. Pemeriksaan dilakukan pada 32 mata yang diambil secara konsekutif dari 23 pasien minimal 1 bulan setelah dilakukan fakoemulsifikasi dan penanaman lensa tanam (asferik dan sferik). Sensitivitas kontras diperiksa pada jarak 1 m di depan lembar kartu dengan tajam penglihatan terbaik pasien setelah koreksi (log MAR) dan keratometri kurang dari 1,5Dioptri (D). Berdasarkan data demografi dan data operasi tidak didapatkan perbedaan yang signifikan, sensitivitas kontras lebih tinggi pada lensa tanam asferik dibandingkan sferik dengan independent t test. Perbedaan yang signifikan ini dapat menjadi pertimbangan untuk pemilihan lensa tanam yang sesuai dengan kebutuhan agar pasien mendapatkan fungsi penglihatan terbaiknya.Kata Kunci: Lensa tanam asferik, lensa tanam sferik, Pelli-Robson contrast sensitivity
ASSOCIATION OF HBA1C AND NEUTROPHIL LYMPHOCYTE RATIO WITH NORMAL-TENSION GLAUCOMA IN METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA RISK PATIENTS Prayitnaningsih, Seskoati; Asrory, Virna Dwi Oktariana; Nusanti, Synthia; Listyaningsih, Erlin; Siswanto, Bambang Budi; Santoso, Anwar
MNJ (Malang Neurology Journal) Vol. 7 No. 2 (2021): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.02.14

Abstract

Background: Normal-Tension_Glaucoma (NTG) is an eye disease and characterize with low intraocular pressure (IOP) levels. In population-based settings, the diagnose of glaucoma is based on the IOP levels of 21 mmHg, and its usually delayed. A recent study HbA1c levels could lead to IOP changes. Obstructive Sleep Apnea (OSA) result oxidative stress that results an altered function of neutrophil in patients with NTG. Objective: To_evaluate the association of HbA1c, Netrophil-to-Lymphocyte Ratio_(NLR) toward NTG as its novel early detection.Methods: This study divided into two groups consisted of Metabolic Syndrome ( MS) + OSA without eye disorder as control (15 subjects) and MS + OSA + NTG patients (14 subjects). IDF criteria was used to established MS, and risk of OSA determined by STOP-BANG Questionnaire. The diagnosis of NTG was confirmed by normal IOP measured by Tonopen. Mean Defect (MD) of visual field evaluated by Automated Humphrey Perimetry, Retinal Nerve Fiber Layer (RNFL) established by OCT. HbA1c measured by ELISA and NLR by flowcytometry. Statistical analysis consisted of comparison and correlation testResults: The ratio of CD was significantly higher in NTG patients (0.54 ± 0.13) compared to control (0.26 ± 0.07; p<0.001). MD was also higher in subjects with NTG (6.80 ± 3.90) compared to control (4.97 ± 2.28; p=0.134). Mean RNFL was lower in subjects with NTG (87.95 ± 28.29) compared to control (95.07 ± 26.66; p=0.035). Positive correlation between HbA1C-MD (r = 0.456, p = 0.013) and NLR-RNFL thinning (r = 0.525, p = 0.003) was existed in Metabolic Syndrome (MS) patients.Conclusion: Patients with MS and OSA risk have an increased risk of NTG. A novel association between Hba1C levels, NLR and NTG was also identified.
PAINFUL OPHTHALMOPLEGIA IN CAROTID-CAVERNOUS FISTULA Wino Vrieda Vierlia; Seskoati Prayitnaningsih
Journal of Pain, Headache and Vertigo Vol. 3 No. 1 (2022): March
Publisher : Journal of Pain, Headache and Vertigo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.605 KB) | DOI: 10.21776/ub.jphv.2022.003.01.1

Abstract

Ophthalmoplegia is defined as a consequence of multiple cranial nerve paralysis innervated the extraocular muscles. The impairment of ophthalmic branch of trigeminal nerve will create a painful condition. Numerous underlying mechanism have been proposed related to painful ophthalmoplegia and carotid-cavernous fistula is one of the main causes with sight and life threatening outcome if left untreated. Carotid-cavernous fistula arises as an abnormal communication between carotid artery and cavernous sinus. Important signs and symptoms of carotid-cavernous fistula may include red eye, proptosis, painful ophthalmoplegia, headache and vision loss. Neuroimaging and angiography are mandatory in diagnosing the disease. Systematized approach and early recognition to the evaluation of carotid-cavernous fistula will lead to prompt management in avoiding morbidity and mortality in severe cases. 
PAINFUL OPHTHALMOPLEGIA IN CAROTID-CAVERNOUS FISTULA Wino Vrieda Vierlia; Seskoati Prayitnaningsih
Journal of Pain, Headache and Vertigo Vol. 3 No. 1 (2022): March
Publisher : Journal of Pain, Headache and Vertigo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2022.003.01.1

Abstract

Ophthalmoplegia is defined as a consequence of multiple cranial nerve paralysis innervated the extraocular muscles. The impairment of ophthalmic branch of trigeminal nerve will create a painful condition. Numerous underlying mechanism have been proposed related to painful ophthalmoplegia and carotid-cavernous fistula is one of the main causes with sight and life threatening outcome if left untreated. Carotid-cavernous fistula arises as an abnormal communication between carotid artery and cavernous sinus. Important signs and symptoms of carotid-cavernous fistula may include red eye, proptosis, painful ophthalmoplegia, headache and vision loss. Neuroimaging and angiography are mandatory in diagnosing the disease. Systematized approach and early recognition to the evaluation of carotid-cavernous fistula will lead to prompt management in avoiding morbidity and mortality in severe cases. 
Prevalensi Dan Karakteristik Penderita Katarak Senilis Di Desa Mendalanwangi, Sidorahayu, Dan Cepokomulyo Di Kabupaten Malang Jawa Timur Nina Handayani; Hendrian Dyatmiko; Seskoati Prayitnaningsih; Sri Andarini
Journals of Ners Community Vol 13 No 1 (2023): Journals of Ners Community
Publisher : Fakultas Ilmu Kesehatan Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/jnerscommunity.v13i1.2580

Abstract

To study the prevalence and characteristics of age related cataract in an adult population in Malang East Java. A population based, cross sectional study of 692 adults (aged > 50 years) were selected from September until December 2019 from Smarthealth Database. The presence of lens opacity was examined by slit lamp biomicroscopy and evaluated according to Lens Opacity Classification System III. The subtype of cataract present, including nuclear, cortical, and posterior subcapsular, were identified from univariate and 95% confidence interval (CI) for association of each specific type of cataract with age, health examination and medical history. A total of 692 patients with aged > 50 years old were included in this study. The prevalence of cataract was 48,7% in participants over 50 years old. From 337 respondents were in the age range 50-70 years, as many as 240 people (71,22%) patients were female, as many as 206 people (61,13%) patients with primary school education, and 151 people (44,8%) patients work as housewife. The standardized prevalences of clinically significant nuclear, cortical, and posterior subcapsular cataract (PSC) were 7,42%, 7.72%, and 5.34% in an adult population in Mendalanwangi, Sidorahayu and Cepokomulyo village in Malang districs. The prevalence of nuclear, cortical and posterior subcapsular cataract increased high prevalence of age related cataract in the adult population remains a severe public health problem.
Prevalensi Dan Karakteristik Penderita Katarak Senilis Di Desa Mendalanwangi, Sidorahayu, Dan Cepokomulyo Di Kabupaten Malang Jawa Timur Nina Handayani; Hendrian Dyatmiko; Seskoati Prayitnaningsih; Sri Andarini
Journals of Ners Community Vol 13 No 1 (2023): Journals of Ners Community
Publisher : Fakultas Ilmu Kesehatan Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/jnerscommunity.v13i1.2754

Abstract

To study the prevalence and characteristics of age related cataract in an adult population in Malang East Java. A population based, cross sectional study of 692 adults (aged > 50 years) were selected from September until December 2019 from Smarthealth Database. The presence of lens opacity was examined by slit lamp biomicroscopy and evaluated according to Lens Opacity Classification System III. The subtype of cataract present, including nuclear, cortical, and posterior subcapsular, were identified from univariate and 95% confidence interval (CI) for association of each specific type of cataract with age, health examination and medical history. A total of 692 patients with aged > 50 years old were included in this study. The prevalence of cataract was 48,7% in participants over 50 years old. From 337 respondents were in the age range 50-70 years, as many as 240 people (71,22%) patients were female, as many as 206 people (61,13%) patients with primary school education, and 151 people (44,8%) patients work as housewife. The standardized prevalences of clinically significant nuclear, cortical, and posterior subcapsular cataract (PSC) were 7,42%, 7.72%, and 5.34% in an adult population in Mendalanwangi, Sidorahayu and Cepokomulyo village in Malang districs. The prevalence of nuclear, cortical and posterior subcapsular cataract increased high prevalence of age related cataract in the adult population remains a severe public health problem.
INDONESIAN PEOPLE RISK FACTORS OF NOCTURIA (TWO OR MORE VOIDS PER NIGHT) OLDER THAN 40 YEARS-OLD Besut Daryanto; Athaya Febriantyo Purnomo; Taufiq Nur Budaya; Seskoati Prayitnaningsih; Nadia Artha Dewi
MNJ (Malang Neurology Journal) Vol. 8 No. 2 (2022): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.02.6

Abstract

Background: Nocturia is a common urinary system disease. Objective: This study aimed to investigate the causes of nocturia in women Indonesian inhabitants aged≥ 40 years. Methods: A stratified sample strategy was used to conduct a randomized cross-sectional study on 562 residents under the age of 40 in Malang City, East Java, Indonesia. A questionnaire was completed, which included socioeconomic demographics, lifestyle characteristics, and clinical history. Each night, nocturia was defined as at least two voids. The chi-squared test was used to determine proportional differences between age and gender groups. Multivariate logistic regression analysis was used to assess gender-related factors. This was determined that P0.05 was statistically significant. Results: Data on 562 people aged 61.60 + 9.81 years eligible for statistical analysis at the end, comprising 185 (32.92%) men and 377 (67.08%) women. Overall nocturia prevalence was 31.8% (179/562). It rose significantly with age (P<0.001) and reached >48% in those above the age of 70. In both men and women, nocturia was linked with diabetes, hypertension, cardiovascular disease, and the overactive bladder symptom score (OABSS) (P0.05). There was no link discovered between nocturia and education, profession, civil status, BMI, female birth history, or the International Prostate Symptom Score. Conclusion: Nocturia is linked to aging, cardiovascular disease, hypertension, OABSS, and diabetes in Indonesians over the age of 40.
HUBUNGAN ANTARA KADAR HEMOGLOBIN A1C DAN NON ARTERITIK ANTERIOR ISKEMIK OPTIK NEUROPATI PADA PASIEN SINDROMA METABOLIK Prayitnaningsih, Seskoati; Rahman, Yeni; Hamid, Aulia Abdul; Rosandi, Rulli
Majalah Kesehatan Vol. 11 No. 1 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.01.2

Abstract

Kebutaan merupakan masalah kesehatan utama di seluruh dunia, termasuk di Indonesia, dan diperkirakan akan semakin meningkat dari waktu ke waktu. Hemoglobin A1c (HbA1c) adalah komponen hemoglobin yang berikatan dengan glukosa dan dapat memprediksi penyakit mikrovaskuler pada pasien diabetes. HbA1c juga diharapkan dapat menjadi biomarker untuk Neuropati Optik Iskemik Anterior Anterior (NAAION) pada pasien sindrom metabolik (SM). Penelitian ini bertujuan untuk menyelidiki hubungan antara HbA1c dan NAAION. Penelitian ini melibatkan 45 pasien yang dibagi menjadi tiga kelompok: kelompok kontrol (15 pasien, 30 mata), kelompok pasien SM tanpa NAAION (15 pasien, 30 mata), dan kelompok pasien SM dengan NAAION (15 pasien, 22 mata). Evaluasi saraf optik meliputi retinal nerve fiber layer (RNFL) dari OCT, sensitivitas kontras dari tes Pelli Robson, dan penilaian cacat lapang pandang (VFD) dari perimetri Humprey. Data dianalisis secara statistik dengan menggunakan uji korelasi Kruskal-Wallis dan Spearman. Hasil penelitian menunjukkan bahwa kadar HbA1c berbeda secara signifikan di antara ketiga kelompok (p = 0,000). Kadar HbA1c rata-rata adalah 5,37% untuk kelompok kontrol, 6,75% untuk pasien MetS tanpa NAAION, dan 7,99% untuk pasien MetS dengan NAAION. Terdapat korelasi negatif yang signifikan antara HbA1c dan defek lapang pandang (p = 0,000, r = -0,568), dan antara HbA1c dan sensitivitas kontras (p = 0,000, r = -0,524). Akan tetapi, terdapat korelasi positif yang signifikan antara HbA1c dan RNFL.
Co-Authors Agustin Iskandar Anwar Santoso Asrory, Virna Dwi Oktariana Athaya Febriantyo Purnomo Aulia Abdul Hamid Bambang Budi Siswanto Dwi Pratiwi, Suryanti Dyatmiko, Hendrian Ensang Timuda, Caesar Erawati, Dini Hamid, Aulia A. Helen Nguda Hendrian Dyatmiko Holipah I Nyoman Surya Ari Wahyudi Indrasworo, Dyah Kautsarani, Intan Listyaningsih, Erlin Nadia Artha Dewi Nina Handayani Nusanti, Synthia Oktarina, Virna Dwi Puspasari, Eka Fajarina Rahmawati, Dessika Rif'ati, Lutfah Rosy Aldina Rulli Rosandi Sri Andarini Sri Andarini Sumarno . Syahira Halisa Syntia Nusanti T Budi Sulistya Taufiq Nur Budaya Vierlia, Wino Vrieda Wienta Diarsvitri Wino Vrieda Vierlia Yanuar, Ferdian Yeni Rahman, Yeni Yudhantara, Dearisa Yuniasih, Kristina Zamroni Afif