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Zulkifli, Nur Farahim
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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In vitro antibiofilm activity of eggshells derived nano-hydroxyapatite (nHA) against Staphylococcus aureus and Streptococcus mutans Suhaimi, Nursyamimi Nasuha; Tarmizi, Nur Hazirah; Zulkifli, Nur Farahim; Amana Allah, Nur Ili Aqilah; Harun, Fakhrul Aimanulhakim; Hanafee, Siti Nur’aisyah Muhamad; Zulkepli, Nur Ayunie; Salim, Fatimah; Mokhtar, Norehan
Pharmacy Reports Vol. 4 No. 3 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.84

Abstract

Dental caries, a highly prevalent oral health condition worldwide, is primarily driven by the biofilm-forming abilities of Staphylococcus aureus and Streptococcus mutans. The interest in eggshell extracts has grown in recent years due to their potential benefits for oral health. Therefore, this study investigated the potential of nano-hydroxyapatite (nHA) derived from eggshells in combating bacterial infections and inhibiting biofilm formation by the selected cariogenic bacteria. The antibacterial activity of the nano-hydroxyapatite extract was initially assessed using the agar well diffusion method. Subsequently, biofilm inhibition was evaluated through crystal violet assays, and the disruption of biofilm structure was visualized under a light microscope. The findings indicated that the nano-hydroxyapatite extract lacked antibacterial activity in inhibiting the growth of both S. aureus and S. mutans. However, the extract demonstrated antibiofilm activity against mono-species biofilms, with observed disruption of biofilm formation upon treatment. As a result, nano-hydroxyapatite extracts derived from eggshells may hold potential as agents for inhibiting biofilm formation associated with dental caries.
Co-Authors Amana Allah, Nur Ili Aqilah Hanafee, Siti Nur’aisyah Muhamad Harun, Fakhrul Aimanulhakim Mokhtar, Norehan Salim, Fatimah Suhaimi, Nursyamimi Nasuha Tarmizi, Nur Hazirah Zulkepli, Nur Ayunie