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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Herbal Medicine Journal Jurnal Pharmactive
Puspita Sari, Dyah Ratna Ayu
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Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Other

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Journal : Jurnal Pharmactive

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UJI TOKSISITAS EKSTRAK ETANOL 96% DAUN MIANA (Plectranthus scutellaroides R.Br) TERHADAP Artemia salina DENGAN METODE BSLT (Brine Shrimp Lethality Test) Puspita Sari, Dyah Ratna Ayu; Putu Yudha Ugrasena; Ni Putu Ayu Desi Astini; I Gede Agus Sindhu A
Journal Pharmactive Vol. 2 No. 2 (2023): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64036/pharmactive.v2i2.34

Abstract

Medicinal plants are one of the efforts used to control disease. The benefits of medicinal plants have been passed down from generation to generation by our ancestors. One plant that has medicinal properties is miana leaves (Plectranthus scutellaroides R.Br). In this research, the extraction method used was maceration, with 96% ethanol solvent. Miana leaf ethanol extract was screened for phytochemicals and toxicity tested using the Brine Shrimp Lethality Test (BSLT) method. Toxicity tests were carried out at various concentrations of 100 ppm, 250 ppm, 500 ppm, 750 ppm and 1000 ppm. The results of phytochemical screening on miana leaves show that miana leaves contain flavonoid compounds, tannins, saponins, steroids, but do not contain alkaloids and triterpenoids. The 96% ethanol extract of miana leaves (Plectranthus scutellaroides R.Br) has an LC50 value of 511.58 ppm, included in the toxic category with an LC50 value in the range of 30-1000 ppm.
UJI TOKSISITAS EKSTRAK ETANOL 96 % DAUN CINCAU HIJAU (Cyclea barbata Miers) TERHADAP Artemia salina Leach. DENGAN METODE Brine Shrimp Lethality Test (BSLT) Puspita Sari, Dyah Ratna Ayu
Journal Pharmactive Vol. 3 No. 1 (2024): Jurnal Pharmactive April
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64036/pharmactive.v3i1.47

Abstract

Medicinal plants are one of the efforts used to control disease. The benefits of medicinal plants have been passed down from generation to generation by our ancestors. One plant that has medicinal properties is green grass jelly (Cyclea barbata Miers). In this research, the extraction method used was maceration, with 96% ethanol solvent. The ethanol extract of green grass jelly leaves was screened for phytochemicals and tested for toxicity using the Brine Shrimp Lethality Test (BSLT) method. Toxicity tests were carried out at various concentrations of 100 ppm, 250 ppm, 500 ppm, 750 ppm and 1000 ppm. The results of the analysis of secondary metabolites contained in the ethanol extract of green grass jelly leaves are alkaloids, flavonoids, tannins and steroids. In the toxicity test, the highest average death percentage was obtained at the 1000 ppm extract concentration variation of 73.33%. From the probit and log concentration data, a linear regression equation y = was obtained with an LC 50 value of 558,25 ppm. This shows that the 96% ethanol extract of green grass jelly leaves (Cyclea barbata Miers) has toxic potential because the LC 50 value is in the range of 30-1000 ppm.
Co-Authors I Gede Agus Sindhu A Indraswari, Putu Ika Indah Mahayani, Ni Putu Rika Ni Putu Ayu Desi Astini Putu Yudha Ugrasena Ugrasena, Putu Yudha