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All Journal HAYATI Journal of Biosciences Jurnal Tumbuhan Obat Indonesia
Wannawijaya, Nashwa Maheswari
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Medicine & Pharmacology Public Health

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Potential of Secondary Metabolites from Acriopsis liliifolia Leaves as a Tyrosinase Inhibitor: Docking Study Khoeriyah, Ni'matul; Wannawijaya, Nashwa Maheswari; Apsari, Cintya Nurul; Nuraini, Latifa
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2246

Abstract

The demand of natural chemicals with high effectiveness and low side effects increases plant exploration, including in the cosmetic and pharmaceutical fields. Trend of skin-lightening products is in great demand, causing its development to overgrow. Acriopsis liliifolia is an orchid species commonly found in Java and its leaves contain many secondary metabolites, thus attracting attention to be studied its potential as a tyrosinase inhibitor to overcome hyperpigmentation. This study explores potential of secondary metabolites in A. liliifolia leaves as tyrosinase inhibitors through microchemical tests, secondary metabolite profiling with LC-HRMS, and docking study using MOE. The results of the microchemical test showed that this orchid contains flavonoid, phenolic, terpenoid, and alkaloid compounds. Secondary metabolite profiling with LC-HRMS produced 130 compounds, then 15 of the most potential compounds were selected. The docking study showed that prolylleucine had lowest S score of -8,738 kJ/mol, lower than native ligand, kojic acid. This indicates that prolylleucine has a significant binding affinity to tyrosinase enzyme receptor through twelve bonds on the active site of enzyme. Prolylleucine can be used as a lead compound for further testing. Keywords: Acriopsis liliifolia, secondary metabolites, leaves, tyrosinase inhibitor, molecular docking.
Potential of Secondary Metabolites from Acriopsis liliifolia Leaves as a Tyrosinase Inhibitor: Docking Study Khoeriyah, Ni'matul; Wannawijaya, Nashwa Maheswari; Apsari, Cintya Nurul; Nuraini, Latifa
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2246

Abstract

The demand of natural chemicals with high effectiveness and low side effects increases plant exploration, including in the cosmetic and pharmaceutical fields. Trend of skin-lightening products is in great demand, causing its development to overgrow. Acriopsis liliifolia is an orchid species commonly found in Java and its leaves contain many secondary metabolites, thus attracting attention to be studied its potential as a tyrosinase inhibitor to overcome hyperpigmentation. This study explores potential of secondary metabolites in A. liliifolia leaves as tyrosinase inhibitors through microchemical tests, secondary metabolite profiling with LC-HRMS, and docking study using MOE. The results of the microchemical test showed that this orchid contains flavonoid, phenolic, terpenoid, and alkaloid compounds. Secondary metabolite profiling with LC-HRMS produced 130 compounds, then 15 of the most potential compounds were selected. The docking study showed that prolylleucine had lowest S score of -8,738 kJ/mol, lower than native ligand, kojic acid. This indicates that prolylleucine has a significant binding affinity to tyrosinase enzyme receptor through twelve bonds on the active site of enzyme. Prolylleucine can be used as a lead compound for further testing. Keywords: Acriopsis liliifolia, secondary metabolites, leaves, tyrosinase inhibitor, molecular docking.
Secondary Metabolite Profiling, In-Silico, and In Vitro Study of Acriopsis liliifolia Roots as Active Cosmetic Ingredients Wannawijaya, Nashwa Maheswari; Khoeriyah, Ni’matul; Apsari, Cintya Nurul; Nuraini, Latifa
HAYATI Journal of Biosciences Vol. 32 No. 5 (2025): September 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.5.1109-1122

Abstract

Beauty and health are currently topics of the global trend. Secondary metabolites from natural sources have become increasingly important for their potential application in cosmetics. This study aims to investigate the potential of Acriopsis liliifolia roots (ALR) as a source of active cosmetic ingredients through secondary metabolite profiling, in silico, and in vitro analysis. A. liliifolia, a medicinally valuable orchid species, was selected due to its rich phytochemical content, which could offer beneficial properties for skin, such as skin-brightening effects. The roots of A. liliifolia were subjected to microchemical assay and metabolite profiling using Liquid Chromatography High-Resolution Mass Spectrometry (LC-HRMS) to determine the bioactive compounds. Additionally, the identified compounds were evaluated through molecular docking studies to assess their interactions with key skin-related enzymes, such as tyrosinase. In vitro studies were conducted to confirm the activity of secondary metabolites of A. liliifolia root on the inhibition of tyrosinase. Microchemical results showed that ALR is positive for phenolics and alkaloids. Metabolite profiling revealed the presence of 125 compounds, then 14 of the most potential compounds were selected. The docking studies exhibit that 1,3-dilinolenoylglycerol had the lowest S-score of -9.54 kJ/mol and lower than kojic acid, suggesting that 1,3-dilinolenoylglycerol has the potential to inhibit tyrosinase. The in vitro studies showed that A. liliifolia roots extract at 250 mg/ml can inhibit tyrosinase (150 U/ml) by 42.56%. However, further research is required to ascertain its potential effect and safety assessment of cosmetics.
Potential of Secondary Metabolites from Acriopsis liliifolia Leaves as a Tyrosinase Inhibitor: Docking Study Khoeriyah, Ni'matul; Wannawijaya, Nashwa Maheswari; Apsari, Cintya Nurul; Nuraini, Latifa
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2246

Abstract

The demand of natural chemicals with high effectiveness and low side effects increases plant exploration, including in the cosmetic and pharmaceutical fields. Trend of skin-lightening products is in great demand, causing its development to overgrow. Acriopsis liliifolia is an orchid species commonly found in Java and its leaves contain many secondary metabolites, thus attracting attention to be studied its potential as a tyrosinase inhibitor to overcome hyperpigmentation. This study explores potential of secondary metabolites in A. liliifolia leaves as tyrosinase inhibitors through microchemical tests, secondary metabolite profiling with LC-HRMS, and docking study using MOE. The results of the microchemical test showed that this orchid contains flavonoid, phenolic, terpenoid, and alkaloid compounds. Secondary metabolite profiling with LC-HRMS produced 130 compounds, then 15 of the most potential compounds were selected. The docking study showed that prolylleucine had lowest S score of -8,738 kJ/mol, lower than native ligand, kojic acid. This indicates that prolylleucine has a significant binding affinity to tyrosinase enzyme receptor through twelve bonds on the active site of enzyme. Prolylleucine can be used as a lead compound for further testing. Keywords: Acriopsis liliifolia, secondary metabolites, leaves, tyrosinase inhibitor, molecular docking.
Co-Authors Apsari, Cintya Nurul Khoeriyah, Ni'matul Khoeriyah, Ni’matul Nuraini, Latifa