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Diversity of Orchid species in the Tilu Mountains Region of Indonesia and the Potential for Phytochemistry Prapitasari, Bela; Rezaldi, Taufiq; Kenza, Masfufah Lutvita; Aliwafa, Ahmad; Gunawan, Dwi Ariya; Nuraini, Latifa
Journal of Tropical Biodiversity and Biotechnology Vol 9, No 3 (2024): September
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.89174

Orchids are one of the largest and globally distributed plant families. Indonesia has the most types of orchids, estimated around 20% from the total species across the world. Mainly orchids used as an ornamental plant. This research aimed to elucidate another potential of orchids as possibly for herbal medicine plant. The potential of orchids as herbal medicine has been known for a long time, but there is lack of well-documented research. The research method used in this research is exploration on predetermined research sites that were conducted in Mount Tilu, West Java on 2022. Observation data of orchids were collected on the sites and the analysis was carried out in a qualitative descriptive approach by describing the data from the research results and comparisons were made through a literature review. Based on the research results, we found about 31 species from 28 genera consisting of 24 epiphytic orchids and 7 terrestrial orchids in the Mount Tilu Kuningan area, West Java. There are 4 endemic species categorised in Java; Chilochista javanica, Crepidium koordesii, Crepidium junghuhnii, and Taeniophyllum biocellatum.

Potential of Secondary Metabolites from Acriopsis liliifolia Leaves as a Tyrosinase Inhibitor: Docking Study Khoeriyah, Ni'matul; Wannawijaya, Nashwa Maheswari; Apsari, Cintya Nurul; Nuraini, Latifa
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2246

The demand of natural chemicals with high effectiveness and low side effects increases plant exploration, including in the cosmetic and pharmaceutical fields. Trend of skin-lightening products is in great demand, causing its development to overgrow. Acriopsis liliifolia is an orchid species commonly found in Java and its leaves contain many secondary metabolites, thus attracting attention to be studied its potential as a tyrosinase inhibitor to overcome hyperpigmentation. This study explores potential of secondary metabolites in A. liliifolia leaves as tyrosinase inhibitors through microchemical tests, secondary metabolite profiling with LC-HRMS, and docking study using MOE. The results of the microchemical test showed that this orchid contains flavonoid, phenolic, terpenoid, and alkaloid compounds. Secondary metabolite profiling with LC-HRMS produced 130 compounds, then 15 of the most potential compounds were selected. The docking study showed that prolylleucine had lowest S score of -8,738 kJ/mol, lower than native ligand, kojic acid. This indicates that prolylleucine has a significant binding affinity to tyrosinase enzyme receptor through twelve bonds on the active site of enzyme. Prolylleucine can be used as a lead compound for further testing. Keywords: Acriopsis liliifolia, secondary metabolites, leaves, tyrosinase inhibitor, molecular docking.

Potential of Secondary Metabolites from Acriopsis liliifolia Leaves as a Tyrosinase Inhibitor: Docking Study Khoeriyah, Ni'matul; Wannawijaya, Nashwa Maheswari; Apsari, Cintya Nurul; Nuraini, Latifa
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2246

The demand of natural chemicals with high effectiveness and low side effects increases plant exploration, including in the cosmetic and pharmaceutical fields. Trend of skin-lightening products is in great demand, causing its development to overgrow. Acriopsis liliifolia is an orchid species commonly found in Java and its leaves contain many secondary metabolites, thus attracting attention to be studied its potential as a tyrosinase inhibitor to overcome hyperpigmentation. This study explores potential of secondary metabolites in A. liliifolia leaves as tyrosinase inhibitors through microchemical tests, secondary metabolite profiling with LC-HRMS, and docking study using MOE. The results of the microchemical test showed that this orchid contains flavonoid, phenolic, terpenoid, and alkaloid compounds. Secondary metabolite profiling with LC-HRMS produced 130 compounds, then 15 of the most potential compounds were selected. The docking study showed that prolylleucine had lowest S score of -8,738 kJ/mol, lower than native ligand, kojic acid. This indicates that prolylleucine has a significant binding affinity to tyrosinase enzyme receptor through twelve bonds on the active site of enzyme. Prolylleucine can be used as a lead compound for further testing. Keywords: Acriopsis liliifolia, secondary metabolites, leaves, tyrosinase inhibitor, molecular docking.

Secondary Metabolite Profiling, In-Silico, and In Vitro Study of Acriopsis liliifolia Roots as Active Cosmetic Ingredients Wannawijaya, Nashwa Maheswari; Khoeriyah, Ni’matul; Apsari, Cintya Nurul; Nuraini, Latifa
HAYATI Journal of Biosciences Vol. 32 No. 5 (2025): September 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.5.1109-1122

Beauty and health are currently topics of the global trend. Secondary metabolites from natural sources have become increasingly important for their potential application in cosmetics. This study aims to investigate the potential of Acriopsis liliifolia roots (ALR) as a source of active cosmetic ingredients through secondary metabolite profiling, in silico, and in vitro analysis. A. liliifolia, a medicinally valuable orchid species, was selected due to its rich phytochemical content, which could offer beneficial properties for skin, such as skin-brightening effects. The roots of A. liliifolia were subjected to microchemical assay and metabolite profiling using Liquid Chromatography High-Resolution Mass Spectrometry (LC-HRMS) to determine the bioactive compounds. Additionally, the identified compounds were evaluated through molecular docking studies to assess their interactions with key skin-related enzymes, such as tyrosinase. In vitro studies were conducted to confirm the activity of secondary metabolites of A. liliifolia root on the inhibition of tyrosinase. Microchemical results showed that ALR is positive for phenolics and alkaloids. Metabolite profiling revealed the presence of 125 compounds, then 14 of the most potential compounds were selected. The docking studies exhibit that 1,3-dilinolenoylglycerol had the lowest S-score of -9.54 kJ/mol and lower than kojic acid, suggesting that 1,3-dilinolenoylglycerol has the potential to inhibit tyrosinase. The in vitro studies showed that A. liliifolia roots extract at 250 mg/ml can inhibit tyrosinase (150 U/ml) by 42.56%. However, further research is required to ascertain its potential effect and safety assessment of cosmetics.

Conservation Strategy and Innovation of Indigenous Indonesian Orchids for Sustainable Practice Khoirul Arifin, Fathur; Nuraini, Latifa; Purba, Endang Rinawati
Biotropika: Journal of Tropical Biology Vol. 13 No. 2 (2025)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2025.013.02

Indigenous Indonesian orchids are one of the biodiversity assets that are threatened with extinction due to habitat destruction, over-exploitation, and climate change factors. Conservation efforts have been developed to protect indigenous orchids in their natural habitat and outside their habitat. Bibliometric analysis is one of the popular tools used to analyse a number of scientific articles. VOSviewer is a method that shows that this study focuses on themes such as biodiversity, propagation technology, and ecotourism utilisation. The purpose of this study is to determine the research trend on the topic of strategy and innovation for the conservation of indigenous Indonesian orchids from year to year and to visualise research related to this topic for sustainable use. Data were collected from the SCOPUS database from 2018 to 2024 using the keywords "orchid species" OR "family Orchidaceae" OR "Orchid genus" OR "Orchid variety" AND strategy OR conservation OR innovation. The VOSviewer method was used to analyse and visualise the results. The results obtained were that the accumulation of search results in the 2018-2024 period was 355 articles. Seventy-two countries contributed to the study and were represented by 162 sponsoring institutions. This indicates that there are still many opportunities and potential from this topic that need to be developed for further research.

Opportunities and challenges for orchid plant cultivation and development in Indonesia Ardiyanti, Kurnia Dwi; Nuraini, Latifa
Open Science and Technology Vol. 4 No. 1 (2024): Open Science and Technology
Publisher : Research and Social Study Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33292/ost.v4i1.112

Keanekaragaman hayati di Indonesia, terutama anggrek sebagai tanaman hias, memiliki sebaran luas. Indonesia memiliki tidak kurang dari 6.000 spesies anggrek, namun sering menghadapi tantangan terkait konservasi dan budidayanya. Dalam menjaga kekayaan keanekaragaman hayati ini, program konservasi anggrek belum dikelola secara optimal sebagai bagian dari upaya pembangunan berkelanjutan untuk mempertahankan kualitas kehidupan manusia dan alam. Metode penelitian dalam studi ini bersifat kualitatif menggunakan pendekatan deskriptif terhadap objek penelitian, yaitu model analisis SOAR. Analisis ini berfokus pada kekuatan (strengths), peluang (opportunities), aspirasi (aspirations), dan hasil (results) melalui studi pustaka dari beberapa buku atau jurnal ilmiah terpublikasi dengan batasan tahun. Budidaya dan pengembangan anggrek akan berfokus pada kekuatan dan peluang terutama yang berkaitan dengan pelestarian keanekaragaman anggrek sehingga kelemahan dan ancaman dapat berkurang. Tantangan budidaya yang dihadapi dalam hal perbanyakan generatif anggrek akan diatasi dengan memanfaatkan teknik kultur in vitro agar budidaya dapat dilakukan dalam waktu yang lebih singkat dengan hasil yang lebih banyak. Teknik kultur in vitro dapat digunakan pula untuk mempertahankan berbagai spesies anggrek alam sebagai salah satu upaya konservasi. Biodiversity in Indonesia, especially orchids as ornamental plants, is widespread. Indonesia has no less than 6,000 orchid species, but often faces challenges related to orchid conservation and cultivation. In maintaining this wealth of biodiversity, orchid conservation programs have not yet been managed optimally as a part of sustainable development effort to sustain the quality of human life and nature. This study employed a qualitative method through a descriptive approach on the research object, namely the SOAR analysis model. This analysis focused on strengths, opportunities, aspirations, and results through literature studies using several books or published scientific journals with year restriction. The cultivation and development of orchids will focus on the strengths and opportunities, especially concerning the preservation of orchid diversity so that the weaknesses and threats can be reduced. The cultivation challenge faced in terms of orchid generative propagation will be overcome by utilizing in vitro culture techniques so that the cultivation can be carried out in a shorter duration and produce larger yields. In vitro culture technique can also be carried out to maintain various nature orchid species as one of the conservation efforts.

Potential of Secondary Metabolites from Acriopsis liliifolia Leaves as a Tyrosinase Inhibitor: Docking Study Khoeriyah, Ni'matul; Wannawijaya, Nashwa Maheswari; Apsari, Cintya Nurul; Nuraini, Latifa
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2246

The demand of natural chemicals with high effectiveness and low side effects increases plant exploration, including in the cosmetic and pharmaceutical fields. Trend of skin-lightening products is in great demand, causing its development to overgrow. Acriopsis liliifolia is an orchid species commonly found in Java and its leaves contain many secondary metabolites, thus attracting attention to be studied its potential as a tyrosinase inhibitor to overcome hyperpigmentation. This study explores potential of secondary metabolites in A. liliifolia leaves as tyrosinase inhibitors through microchemical tests, secondary metabolite profiling with LC-HRMS, and docking study using MOE. The results of the microchemical test showed that this orchid contains flavonoid, phenolic, terpenoid, and alkaloid compounds. Secondary metabolite profiling with LC-HRMS produced 130 compounds, then 15 of the most potential compounds were selected. The docking study showed that prolylleucine had lowest S score of -8,738 kJ/mol, lower than native ligand, kojic acid. This indicates that prolylleucine has a significant binding affinity to tyrosinase enzyme receptor through twelve bonds on the active site of enzyme. Prolylleucine can be used as a lead compound for further testing. Keywords: Acriopsis liliifolia, secondary metabolites, leaves, tyrosinase inhibitor, molecular docking.

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