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Abbas, Alyaa Khider
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Chemical Engineering, Chemistry & Bioengineering Chemistry

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Preparation, Structural Identification, and Biomedical Evaluation of Some New Complexes Abbas, Alyaa Khider; Fadhil, Asmaa Edrees
Indonesian Journal of Chemistry Vol 24, No 6 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95759

Abstract

A new nano azo ligand, [2-amino-6-oxo-6,7-dihydro-1H-purin-8-yl)diazenyl)nitrobenzene (AH), and its Ag(I), Cu(II), and Zn(II) complexes were successfully synthesized and characterized using elemental analyses, magnetic susceptibility, molar conductance, and spectroscopic techniques (FTIR, UV-vis, ¹H-NMR), along with thermal analysis. FTIR confirmed the ligand acts as a neutral N,N-bidentate. The metal-to-ligand ratio was determined to be 1:1 for Ag(I) and Zn(II) complexes and 1:2 for the Cu(II) complex. Stability constants and Gibbs free energy, assessed via spectrophotometry, indicated high stability for all complexes. SEM and X-ray diffraction revealed nanoscopic properties for the Ag(I) and Cu(II) complexes. The antimicrobial activity against Staphylococcus aureus, Klebsiella pneumoniae, and Candida albicans species showed good efficiency compared to reference drugs. The ligand also exhibited moderate antioxidant activity using the DPPH assay. Additionally, the Zn(II) complex demonstrated effective anti-inflammatory activity, promoting wound healing within 14 days, compared to 16 days with silver sulfadiazine and 18 days without treatment.
Synthesis and Identification with Biological Evaluation of Some Metal Ions Complexes Derived from Thymine-Azo Ligand Al-mizher, Tabark Taha; Abbas, Alyaa Khider
Indonesian Journal of Chemistry Vol 25, No 3 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.103682

Abstract

New series of Ag(I) and Cu(II) complexes with general formulas of Ag(AAT)(H2O)]NO3·H2O and Cu(AAT)(H2O)3]Cl2·H2O from 6-((5-chloro-2-hydroxyphenyl)diazenyl)-5-methylpyrimidine-2,4(1H,3H)-dione (AAT) were synthesized. By using FTIR, UV-vis, MS, and 1H-NMR, their molecular structural and binding properties were confirmed, which indicated that the AAT ligand acts as a neutral tridentate O, N, and N, forming tetrahedral geometry with Ag-AAT and distorted octahedral with Cu-AAT. Additionally, C.H.N analysis, magnetic susceptibility, molar conductivity, and thermal analysis were used to identify the synthesized compounds' stability and molecular formula and explore their physical and chemical properties. XRD and AFM were also examined, where the ligand and Cu(II) complex exhibited nanoscale properties. The biological potential of these compounds was also investigated by testing their antioxidant activity. Furthermore, the Cu(II) complex was investigated for its effects on liver function and histological abnormalities in male albino rats. The enzymatic activities of liver markers such as glutamic-oxaloacetic transaminase, glutamic-pyruvate transaminase, and alkaline phosphatase were measured to determine the hepatoprotective properties. Histological investigations of liver tissues revealed further evidence for the biological effects of the copper compound. These results revealed the potential applications of Ag(I) and Cu(II) complexes derived from the thymine-azo ligand.
Co-Authors Al-mizher, Tabark Taha Fadhil, Asmaa Edrees