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All Journal Journal of Tropical Biodiversity and Biotechnology Science and Technology Indonesia BIOVALENTIA: Biological Research Journal
Wibowo, Des Saputro
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics

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Biotransformation of n-butanol to Fruity-Like Bio-Flavour by Indonesian Lactic Acid Bacteria Setiyoningrum, Fitri; Adi, Deddy Triyono Nugroho; Priadi, Gunawan; Wibowo, Des Saputro; Octaviana, Senlie; Afiati, Fifi; Fidriyanto, Rusli; Prasetyo, Doni Dwi; Siregar, Abdul Rahman; Vincentlau, Dharma
Journal of Tropical Biodiversity and Biotechnology Vol 9, No 4 (2024): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.93537

Abstract

Microbial production of aroma compounds is a promising alternative to extracting plants or chemical synthesis. In our research, the Indonesian lactic acid bacteria (LAB) have been utilised as producing fruity-like bio flavour by biotransformation approach using n-butanol as a precursor. The aims of our research are to identify LAB- secondary metabolites categorised fruity-like bio flavour and investigate the changes of glucose, mannitol, xylose, lactic acid and acetic acid in growth medium after fermentation. Our result research showed that n-butanol could be transformed to several fruity like bio flavour such as ethyl butyrate, butyl acetate, butyl formate, ethyl 2-methylbutanoate, ethyl 3-methylbutanoate, 2-heptanone, butyl propanoate, butyl propanoate, butyl 2-methylbutanoate, butyl isovalerate, butyl pentanoate, and butyl hexanoate. All of LABs consumed above 75% of glucose and only Lactococcus lactis KGB1 consumed all the mannitol on fermentation medium. In addition, Lactococcus lactis KGB1 produced the highest xylose, 11.87 g/L LABs produced. Based on the amount of fruity-like bio flavour compound generated, Lactobacillus fermentum WKS2, Lactobacillus fermentum KGL2, Lactococcus lactis KK4, Lactobacillus fermentum WKS3, Lactococcus lactis KGB1, and Lactobacillus fermentum KGL7 could be considered as agent fruity-like bio flavour by biotransformation approach.
Enhancing Iota Carrageenan Soft Capsules with Modified Starch Perwatasari, Dayu Dian; Putri, Renny Primasari Gustia; Puspantari, Widya; Royanti, Ida; Wibowo, Des Saputro; Hidayat, Taufik; Wahyuni, Tuti; Purwoto, Heri; Manalu, Lamhot Parulian; Laksono, Hendrawan
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.183-190

Abstract

Due to the increasing demand for gelatin alternatives, iota carrageenan, a polymer derived from seaweed, is being explored as a potential base material for soft capsule production. However, the rheological properties of iota carrageenan alone are insufficient for commercial manufacturing, necessitating the addition of fillers such as modified starches. This study evaluates the performance of iota carrageenan-based soft capsule shells using modified cassava, potato, and sago starches as fillers. Various mechanical and rheological properties were assessed, including elongation, stickiness, tensile strength, and viscosity. The results demonstrated that modified cassava starch provided the best overall balance of mechanical properties, exhibiting superior moldability (47.56 mm elongation), flexibility, and moderate stickiness (567.45 gf). Scanning Electron Microscopy (SEM) analysis revealed that cassava starch capsules had a more uniform outer surface with smoother internal morphology than other starches. These findings suggest that modified cassava starch is a promising candidate for large-scale production of high-quality soft capsules.
Biotherapeutics and Antibiofilm Properties of Sponge-Associated Bacteria from Tanjung Tiram Mangroves, Southeast Sulawesi Mamangkey, Jendri; Sunarto, Sunarto; Fadjri, Corrina Lailatul; Irawan, Herman; Huda, Muhammad Komarul; Wibowo, Des Saputro; Mutiara, Ilma
BIOVALENTIA: Biological Research Journal Vol. 11 No. 2 (2025)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24233/biov.11.2.2025.504

Abstract

 The search for new therapeutic agents has increasingly focused on bioactive compounds from sponge-associated bacteria. This study investigated bacterial symbionts of marine sponges collected from the mangrove ecosystem of Tanjung Tiram, Southeast Sulawesi, which have not been previously explored for their bioactive potential. Thirty bacterial isolates were screened in triplicate for antibacterial, antioxidant, antidiabetic, and antibiofilm activities. Antibacterial activity was evaluated using the disc diffusion method, antioxidant capacity by DPPH radical scavenging assay, α-glucosidase inhibition for antidiabetic potential, and antibiofilm activity by the crystal violet binding method. Several isolates showed notable bioactivities: strain Sp.8 produced the largest inhibition zone against Escherichia coli (15 mm), and Sp.14 showed the strongest inhibition against Staphylococcus aureus (23 mm). The most active antioxidant strains (Sp.14, Sp.15, Sp.13, and Sp.6) exhibited radical scavenging activity above 80%, while Sp.13, Sp.15, Sp.31, and Sp.37 showed high α-glucosidase inhibition (>74%). Strains Sp.38 and Sp.12 significantly reduced biofilm formation by E. coli and S. aureus, respectively. These findings reveal the untapped potential of sponge-associated marine bacteria from Tanjung Tiram as promising sources of bioactive metabolites for future drug discovery.
Co-Authors Abdul Rahman Siregar Adi, Deddy Triyono Nugroho Dayu Dian Perwatasari Fadjri, Corrina Lailatul Fidriyanto, Rusli Fifi Afiati Hendrawan Laksono Huda, Muhammad Komarul Irawan, Herman Jendri Mamangkey Lamhot Parulian Manalu, Lamhot Parulian Mutiara, Ilma Prasetyo, Doni Dwi Priadi, Gunawan Purwoto, Heri Puspantari, Widya Putri, Renny Primasari Gustia Royanti, Ida Senlie Octaviana Setiyoningrum, Fitri Sunarto Sunarto Taufik Hidayat Vincentlau, Dharma Wahyuni, Tuti