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All Journal Padjadjaran Journal of Dentistry Jurnal Widya Medika
Aini Gumilas, Nur Signa
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The association between poor oral hygiene and infective endocarditis risk in rheumatic heart disease patients: a systematic review Amiria, Farah; Aini Gumilas, Nur Signa
Padjadjaran Journal of Dentistry Vol 37, No 2 (2025): July 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no2.59405

Abstract

Introduction: Infective endocarditis (IE) is a heart condition that may result from subacute bacterial infections. One cause of IE is oral bacterial infections, particularly Streptococcus species, which enter the blood vessels through injured gingiva during tooth brushing or dental procedures. Rheumatic heart disease (RHD) is a major predisposing factor in developing countries, with viridans streptococci implicated in its etiology. This background highlights the importance of maintaining oral hygiene, especially in RHD patients, to reduce the risk of IE. This systematic review aims to investigate the association between poor oral hygiene and the risk of IE in patients with RHD. Method: A systematic review was conducted in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Articles published between 2014 and 2024 were sourced from PubMed, Scopus, and Google Scholar using specific keyword combinations related to IE, RHD, and oral health. Inclusion and exclusion criteria were applied based on the PECO framework. Results: A total of four eligible studies were identified. The findings suggest that RHD patients with poor oral hygiene are more vulnerable to developing IE due to an increased risk of bacteremia originating from oral infections. Conclusion: Poor oral hygiene is associated with an increased risk of infective endocarditis in patients with rheumatic heart disease. Bacterial adherence to damaged heart valves can lead to biofilm formation and vegetations, increasing the likelihood of infection. Preventive dental care and appropriate prophylactic measures should be prioritized in this high-risk population to reduce disease burden.
ANTIDIABETIC EFFECT TEST OF CENTELLA ASIATICA EXTRACT IN HYPERCHOLESTEROLEMIA RAT MODELS Nafiisah, Nafiisah; Aini Gumilas, Nur Signa; Harini, Ika Murti
JURNAL WIDYA MEDIKA Vol. 10 No. 2 (2024): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v10i2.6031

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Introduction: High blood sugar levels can lead to hypercholesterolemia, a condition where cholesterol levels in the blood exceed normal values. The active compounds in Centella asiatica (pegagan) have the potential to act as antidiabetic agents by stimulating insulin production by pancreatic beta cells. Objective: This study aims to determine the effect of Centella asiatica extract on lowering fasting blood glucose (FBG) levels in hypercholesterolemia rat models. Methods: Thirty-two test animals were divided into 4 groups: normal control, negative control, positive control (Simvastatin 1.8 mg/kgBW/day), and treatment (Centella asiatica extract 500 mg/kgBW/day). Hypercholesterolemia was induced using 2% cholesterol and 0.2% cholic acid. FBG measurement was performed after 5 weeks of administration of Centella asiatica extract and Simvastatin. Data analysis used one-way ANOVA and post hoc Bonferroni tests. Results: The mean FBG (mg/dL) in P1=70.85±1.89; P2=151.82±2.91; P3=92.34±1.86; and P4=83.89±2.17. The one-way ANOVA test results showed statistically significant differences (p
Co-Authors Farah Amiria, Farah Harini, Ika Murti Nafiisah, Nafiisah