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All Journal Scientia Psychiatrica Sriwijaya Journal of Otorhinolaryngology
Vidhya Sathyakirti
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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The Impact of Gastroesophageal Reflux Disease (GERD) on Pharyngeal Mucosal Changes: A Case-Control Study in Indonesia Dedi Sucipto; Nurul Hanifah; Vidhya Sathyakirti; Louisa Istarini; Syaifudin Syaifudin
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 1 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i2.94

Abstract

Introduction: Gastroesophageal reflux disease (GERD) is a prevalent digestive disorder with potential extra-esophageal manifestations, including laryngopharyngeal reflux (LPR). LPR can lead to various pharyngeal mucosal changes, impacting voice quality and overall well-being. This study aimed to investigate the association between GERD and pharyngeal mucosal changes in a population in Indonesia. Methods: A case-control study was conducted at a tertiary hospital in Indonesia, involving 100 participants diagnosed with GERD (cases) and 100 participants without GERD (controls). All participants underwent a comprehensive ear, nose, and throat (ENT) examination, including flexible nasopharyngoscopy, to assess pharyngeal mucosal changes. The Reflux Symptom Index (RSI) questionnaire was used to evaluate the severity of reflux symptoms. Data were analyzed using SPSS software, employing chi-square and logistic regression analyses to determine the association between GERD and pharyngeal mucosal changes. Results: The study found a significantly higher prevalence of pharyngeal mucosal changes in the GERD group compared to the control group (78% vs. 22%, p<0.001). Erythema, edema, and posterior pharyngeal wall cobblestoning were the most common findings in GERD patients. The severity of reflux symptoms, as measured by the RSI, was positively correlated with the presence and severity of pharyngeal mucosal changes. Conclusion: GERD is significantly associated with pharyngeal mucosal changes in the Indonesian population studied. These findings underscore the importance of recognizing and managing LPR in patients with GERD to prevent potential complications and improve quality of life.
Psychobiological Mechanisms of Resilience in the Pesantren Ecology: A Comparative Structural Equation Modeling of Distress, Coping, and Salivary Cortisol between Boarding and Non-Boarding Santri in East Java Winata Putri; Irna Nettles; Theresia Putri Sinaga; Vidhya Sathyakirti; Sari Sulistyoningsih
Scientia Psychiatrica Vol. 6 No. 3 (2025): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v6i3.200

Abstract

Introduction: The Pesantren (Islamic boarding school) represents a unique educational ecosystem in Indonesia that imposes distinct psychosocial demands on students (Santri). While the academic outcomes of this system are well-documented, the psychobiological divergences between boarding (Mukim) and non-boarding (Kalong) students regarding stress adaptation remain under-researched. Methods: This cross-sectional comparative study involved 500 adolescents (ages 15-18) from four large Pesantrens in East Java, stratified into Boarding (n = 250) and non-boarding (n = 250) groups. Participants completed the Kessler Psychological Distress Scale (K-10), the Connor-Davidson Resilience Scale (CD-RISC-25), and the Brief-COPE. Additionally, morning salivary cortisol samples were collected to assess hypothalamic-pituitary-adrenal (HPA) axis activity. Data were analyzed using MANCOVA and Structural Equation Modeling (SEM). Results: Boarding students exhibited significantly higher baseline psychological distress (p < 0.001) and elevated cortisol levels compared to non-boarders. However, they also demonstrated significantly higher resilience scores and utilization of adaptive religious coping strategies. SEM analysis revealed that while boarding status is a predictor of physiological stress, its impact on psychological distress is fully mediated by adaptive coping mechanisms and community integration. Conclusion: Boarding students face heightened physiological stress loads but possess superior compensatory resilience mechanisms driven by religious coping. Interventions should focus on strengthening these adaptive pathways.
Co-Authors Dedi Sucipto Irna Nettles Louisa Istarini Nurul Hanifah Sari Sulistyoningsih Syaifudin Theresia Putri Sinaga Winata Putri