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All Journal Medali Jurnal : Media Dental Intelektual Dental Journal (Majalah Kedokteran Gigi)
Wicaksono, Imme Kris
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Dentistry Health Professions Public Health

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Pharmacological and low-level laser therapy in radiation-induced oral mucositis in patients with head and neck cancer Wicaksono, Imme Kris; Hapid, M. Hasan; Dewi, Tenny Setiani; Sufiawati, Irna; Kusumadjati, Adji
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 1 (2025): March
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i1.p95-99

Abstract

Background: Oral mucositis (OM) is common in people undergoing radiotherapy, chemotherapy, or a combination of both. Pharmacological and low-level laser therapy (LLLT) are potential treatments to reduce pain and accelerate the healing process. Purpose: The aim of this case report is to describe the effectiveness of combining pharmacological therapy and LLLT for OM. Case: A 54-year-old man with post-hemi glossectomy diagnosed with tongue cancer was referred from the radio-oncology department with complaints of painful sores all over the oral cavity after receiving radiotherapy. The canker sores worsened when eating but felt more comfortable when drinking cold water. Intraoral examination revealed erythematous lesions accompanied by fibrinous pseudomembranes and yellowish-white plaques, which could be scraped off, leaving erythematous areas with pain. These lesions were present on the upper and lower labial mucosa and the right and left buccal mucosa. The diagnosis was grade-3 OM, according to the World Health Organization (WHO) criteria. Case management: Pharmacological therapy included 0.025% hyaluronic acid gargles three times a day and the use of LLLT with a wavelength of 976 nm. Conclusion: The combination of pharmacological therapy with LLLT was effective in maintaining and improving the condition of the oral mucosa by reducing pain and ultimately improving the patient’s quality of life.
Beyond A Common Infection: Comprehensive Oral Management Strategies For Severe Recurrent Intraoral Herpes Wicaksono, Imme Kris; Hartono, Cindy Karina; Djuarsa, Ivan; Januarisca, Bernadeth Vindi
Jurnal Medali Vol 8, No 1 (2026): Media Dental Intelektual February 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.8.1.75-79

Abstract

Background: Recurrent intraoral herpes (RIH) is caused by reactivation of Herpes Simplex Virus type 1 (HSV-1). While HSV-1 infection is usually self-limiting, severe cases requiring hospitalization are uncommon and present significant clinical challenges. Delayed diagnosis or inadequate antiviral therapy can contribute to disease progression and increased morbidity.This case study aims to illustrate an effective therapeutic approach for managing severe RIH in a patient presenting with intense pain and difficulty swallowing, emphasizing strategies that enhance patient comfort and improve clinical outcomes.Case: An 24-year-old male presented in a markedly weakened condition with severe difficulty swallowing. Examination revealed multiple ulcerative lesions of varying sizes diffusely throughout the oral cavity, with extensive erythema and severe pain (Visual Analog Scale [VAS] score: 8). Vital signs at presentation were blood pressure 90/60 mmHg and oxygen saturation 91%. Due to his weakened state and significant pain, inpatient care was required for close monitoring and nutritional support.Treatment included systemic acyclovir 400 mg, multivitamins, 0.025% hyaluronic acid mouthwash, 0.9% saline, and petroleum jelly 100%. After seven days of therapy, the patient clinically improved. Lesions gradually decreased in size, number, erythema subsided, and pain significantly reduced, allowing resumption of oral intake. VAS score decreased from 8 at admission to 5 at discharge. Conclusion:Severe RIH can necessitate hospitalization and multidisciplinary management. Early initiation of systemic antiviral therapy combined with supportive care effectively reduces symptoms, improves nutritional intake, and prevents further deterioration. Timely, comprehensive intervention is critical for optimal outcomes in severe HSV-1 reactivation.
Co-Authors Adji Kusumadjati Djuarsa, Ivan Hapid, M. Hasan Hartono, Cindy Karina Irna Sufiawati Januarisca, Bernadeth Vindi Tenny Setiani Dewi