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All Journal Pharmaceutical Reports Journal of Scientific Insights Jurnal Teknologi dan Sains Modern
Musdalifah, A.
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Antioxidant Activity of Water and Ethyl Acetate Fractions of Qust Al Hindi Root (Saussurea lappa) Using DPPH Inhibition Method Musdalifah, A.; Sukmawati, Sukmawati; Tahir, Masdiana
Pharmaceutical Reports Vol 3, No 2 (2024): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i2.312

Abstract

Free radicals are molecules that do not have an electron pair in the outer shell, making them highly reactive. Oxidation due to free radicals can be prevented and inhibited by substances, namely antioxidants. Natural antioxidants are obtained from plants or fruits, one of which is Qust al hindi (Saussurea lappa).  Qust al hindi is a plant native to India that is used as a traditional medicine. Qust al hindi contains various phytochemical compounds, one of which is flavonoid compounds that function as antioxidants. The purpose of this study was to analyze the antioxidant activity of water and ethyl acetate fractions of qust al hindi plant roots by 1,1-diphenyl-2picrylhydrazyl (DPPH) silencing method using UV-Vis spectrophotometry based on the calculation of IC50 value using GraphPad Prism Application. The results of this study indicate that the water and ethyl acetate fractions of qust al hindi plant roots have antioxidant activity against DPPH free radicals with IC50 values of 203.5 µg/mL; 193.3 µg/mL, respectively, which are included in the very weak and weak antioxidant groups.
Active Compounds of Usnea Lichen and Their Potential as Pharmaceutical Raw Materials: A Review of Phytochemistry and Pharmacological Activities Musdalifah, A.; Nurul Inaya Muhtar
Journal of Scientific Insights Vol. 2 No. 6 (2025): December
Publisher : Science Tech Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69930/jsi.v2i6.708

Abstract

Lichens represent a unique symbiotic system and an important yet relatively underexplored source of bioactive natural products. Among them, the genus Usnea has attracted considerable scientific interest due to its chemically diverse secondary metabolites and wide range of pharmacological activities. However, current knowledge integrating phytochemical diversity, pharmacological mechanisms, and safety considerations remains fragmented. Therefore, this review aims to systematically summarize the major bioactive compounds identified in Usnea species and critically evaluate their pharmacological potential as pharmaceutical raw materials. Particular attention is given to polyketide-derived metabolites, including usnic acid, depsides, and depsidones, which exhibit diverse phenolic structures and contribute to antimicrobial, antioxidant, anti-inflammatory, and anticancer activities through mechanisms such as membrane disruption, free radical scavenging, modulation of inflammatory pathways, and apoptosis induction. Furthermore, toxicity concerns, especially hepatotoxicity associated with high-dose usnic acid, are discussed to highlight the need for improved safety evaluation and formulation strategies. The exploration of Usnea-derived natural products also supports global health initiatives, particularly the Sustainable Development Goals (SDGs), including SDG 3.4 (reducing premature mortality from non-communicable diseases) and SDG 3.b (promoting research and development of new medicines). Overall, Usnea represents a promising source of bioactive compounds for sustainable natural product-based pharmaceutical development.
Metabolit Sekunder Lichen dan Aktivitas Biologisnya: Mini Review Musdalifah, A.
Jurnal Teknologi dan Sains Modern Vol. 3 No. 1 (2026): Januari-Februari
Publisher : CV. Science Tech Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69930/jtsm.v3i1.705

Abstract

Lichen merupakan organisme simbiotik antara fungi dan alga atau sianobakteri yang mampu menghasilkan berbagai metabolit sekunder dengan struktur kimia unik. Senyawa-senyawa tersebut tidak berperan langsung dalam pertumbuhan primer, tetapi memiliki fungsi ekologis penting sebagai mekanisme pertahanan terhadap stres lingkungan. Dalam beberapa dekade terakhir, metabolit sekunder lichen mendapat perhatian luas karena menunjukkan beragam aktivitas biologis, seperti antimikroba, antioksidan, dan antikanker. Mini review ini bertujuan untuk merangkum keanekaragaman golongan metabolit sekunder lichen serta aktivitas biologis yang telah dilaporkan. Hasil kajian menunjukkan bahwa golongan depsida, depsidon, dan dibenzofuran merupakan senyawa dominan yang berkontribusi terhadap bioaktivitas lichen. Potensi farmakologisnya menjadikan lichen sebagai sumber kandidat senyawa bioaktif yang menjanjikan untuk pengembangan obat berbasis bahan alam.
Co-Authors Masdiana Tahir Muhtar, Nurul Inaya Sukmawati Sukmawati