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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Cancer
Hibatullah, Muhammad Naufal
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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In silico Investigation on Clopidogrel, Prasugrel and Ticagrelor as Potential Mono Antiplatelet Therapy for Acute Coronary Syndrome Hibatullah, Muhammad Naufal; Suryono, Suryono; Rachmania, Sheilla
Molecular and Cellular Biomedical Sciences Vol 8, No 3 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i3.464

Abstract

Background: In acute coronary syndrome (ACS), antiplatelet therapy is crucial for inhibiting platelet aggregation. Dual antiplatelet therapy (DAPT) commonly employs aspirin along with clopidogrel, prasugrel, or ticagrelor. This is well known that aspirin acts as a cyclooxygenase (COX)-1 inhibitor, while clopidogrel, prasugrel, and ticagrelor act as P2Y12 inhibitors. Despite DAPT's proven efficacy in more effectively reducing cardiovascular events in ACS patients, this is associated with an increased risk of bleeding compared to mono antiplatelet therapy (MAPT). To minimize the cost and side effect that might arise from the use of DAPT, this is necessary to assess the potential of MAPT using a P2Y12 inhibitor drug, to understand whether they are capable of binding to both COX-1 and P2Y12. Hence, this study was conducted to identify P2Y12 inhibitor drugs that have the ability to bind to COX-1, allowing them to be proposed as MAPT.Materials and methods: Molecular docking was employed to assess binding affinity, interaction types, amino acid residues, binding distances, and visualizations in both 3D and 2D formats. The applications utilized were BIOVIA Discovery Studio and AutoDock, while the websites utilized were research collaboratory for structural bioinformatics protein data bank (RCSB PDB) and PubChem.Results: In silico findings reveal differences in binding strength among clopidogrel, prasugrel, and ticagrelor to COX-1 and P2Y12, with ticagrelor emerging as the stronger ligand due to a higher number of bindings and/or closer binding distances. Notably, only prasugrel and ticagrelor demonstrate the ability to bind to the active site of COX-1.Conclusion: Therefore, prasugrel and ticagrelor emerge as potential MAPT agents for ACS patients.Keywords: clopidogrel, prasugrel, ticagrelor, antiplatelet, ACS, in silico, molecular docking
Global Research Trends on Ablation for Hepatocellular Carcinoma: Insights from A Comprehensive Bibliometric Analysis and Visualization Athoillah, Nabil; Hibatullah, Muhammad Naufal; Buaji, Brilliantara; Rayyan, Muhammad Isra; Febriakhano, Aji
Indonesian Journal of Cancer Vol 20, No 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1443

Abstract

Background: Ablation has been intensively studied as an effective and minimally invasive management for hepatocellular carcinoma (HCC). Plenty of publications have been written in the last century about ablation in HCC, but no bibliometric analysis has comprehensively analyzed the topic of ablation in HCC. This study aimed to explore the recent development of HCC ablation using bibliometric analysis. Methods: Publication data were comprehensively retrieved from the Scopus database using total sampling technique from the first publication to August 3, 2024. Then, the data were analyzed and visualized using VOSviewer and RStudio software to reveal publications per year, most frequently occurring keywords, most productive authors and countries, article citations, and international collaborations.Results: Thirteen thousand, nine hundred fifty-five publications were extracted from the Scopus database between 1950 and 2024. The research trend on ablation and HCC has increased massively, especially since 1999. China and the World Journal of Hepatology were identified as the most productive countries and journals in this field. In addition, Kudo Masatoshi has 187 articles and is the most influential researcher in this field. The bibliometric data illustrated that the most frequently reviewed ablation modality was radiofrequency ablation, followed by microwave ablation, percutaneous ethanol injection, and high-intensity focused ultrasound. In addition, the bibliometric analysis showed that recent ablation research trends favored microwave ablation and high-intensity focused ultrasound as ablation techniques, using efficacy and safety parameters as primary outcomes. Meta-analysis is a research method related to ablation that has primarily been conducted recently. Ablation modalities are also frequently studied simultaneously with immunotherapy, systemic, and locoregional modalities.Conclusions: Current research on HCC ablation continues to increase, with study trends shifting from percutaneous ethanol injection and radiofrequency ablation to microwave ablation and high-intensity focused ultrasound. Meta-analysis and efficacy-safety are essential research methods and outcomes to review.
Co-Authors Athoillah, Nabil Buaji, Brilliantara Febriakhano, Aji Rayyan, Muhammad Isra Sheilla Rachmania, Sheilla Suryono Suryono