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All Journal Narra J JURNAL BIOLOGI PAPUA
Yudha, Donan S.
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Comparative analysis of hemotoxic, myotoxic, and inflammatory profiles of Calloselasma rhodostoma and Trimeresurus insularis venoms in mice Aphrodita, Adiva; Sentono, Diva N.; Yudha, Donan S.; Purwestri, Yekti A.; Nuringtyas, Tri R.; Raharjo, Slamet; Wahid, Isra; Rahmi, Sri N.; Wahyudi, Setyanto T.; Sofyantoro, Fajar
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v5i2.1874

Abstract

Snakebite envenomation remains a significant medical concern, particularly in tropical regions where venomous snakes such as Calloselasma rhodostoma and Trimeresurus insularis are prevalent. Both venoms are known for their potent hemotoxic, myotoxic, and inflammatory effects, yet their differential impacts on systemic physiological pathways remain unclear. The aim of this study was to characterize the hematological, myotoxic, and inflammatory effects of C. rhodostoma and T. insularis venoms in a murine model and to explore their influence on systemic factors such as insulin-like growth factor 1 (IGF-1), which is critical for muscle repair and inflammation regulation. Mice were exposed to varying doses (20–100 µg) of C. rhodostoma and T. insularis venoms. Hematological parameters, muscle degeneration, inflammatory cell infiltration, and plasma IGF-1 levels were assessed to evaluate the venoms' systemic and local effects. Our data indicated that C. rhodostoma venom induced significant changes in blood coagulation, muscle edema, and inflammatory infiltration, with pronounced effects even at lower doses. Conversely, T. insularis venom showed a dose-dependent suppression of IGF-1 levels, highlighting its unique systemic impact. Both venoms caused severe muscle damage, characterized by structural disintegration and increased leukocyte infiltration, with C. rhodostoma eliciting a stronger inflammatory response at lower doses.Snakebite envenomation remains a significant medical concern, particularly in tropical regions where venomous snakes such as Calloselasma rhodostoma and Trimeresurus insularis are prevalent. Both venoms are known for their potent hemotoxic, myotoxic, and inflammatory effects, yet their differential impacts on systemic physiological pathways remain unclear. The aim of this study was to characterize the hematological, myotoxic, and inflammatory effects of C. rhodostoma and T. insularis venoms in a murine model and to explore their influence on systemic factors such as insulin-like growth factor 1 (IGF-1), which is critical for muscle repair and inflammation regulation. Mice were exposed to varying doses (20–100 µg) of C. rhodostoma and T. insularis venoms. Hematological parameters, muscle degeneration, inflammatory cell infiltration, and plasma IGF-1 levels were assessed to evaluate the venoms' systemic and local effects. Our data indicated that C. rhodostoma venom induced significant changes in blood coagulation, muscle edema, and inflammatory infiltration, with pronounced effects even at lower doses. Conversely, T. insularis venom showed a dose-dependent suppression of IGF-1 levels, highlighting its unique systemic impact. Both venoms caused severe muscle damage, characterized by structural disintegration and increased leukocyte infiltration, with C. rhodostoma eliciting a stronger inflammatory response at lower doses.
Keanekaragaman Morfologis Ikan Uceng Nemacheilus fasciatus (Valenciennes, 1846) di Perairan Sungai Bogor, Temanggung dan Blitar Yudha, Donan S.; Nafita, Hamdani F.
Jurnal Biologi Papua Vol 16 No 2 (2024)
Publisher : Jurusan Biologi FMIPA Universitas Cenderawasih

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31957/jbp.3400

Abstract

Uceng (Nemacheilus fasciatus) is relatively common fish in Indonesia. Characteristics of this are small and slender bodied with a line marking on the lateral part of its body. This species is distributed in Java and Sumatra. There are differences on geographical conditions such as water levels, water currents and the environment in each distribution area of this species. These differences may result in both morphology and genetic variations. This study aimed to determine morphological variations of uceng fish among populations from three different regions of rivers in Java, namely Cijeruk River in Bogor, Progo River in Temanggung and Lekso River in Blitar; and to compare its morphological variations between populations from those three difference regions. Methods used in this study was purposive sampling to collect samples, meristic and morphometric data acquisition, furthermore those data were analyzed using kruskall-Walis to test significant difference between each morphological characteristic, Mann-Whitney to determine the differences between populations and finally PCA data analysis to determine distributional patterns between each populations. Result showed significant morphological differences (p<0.005) between populations from three different rivers and there were differences in several morphometric and meristic characteristics between each populations.    Key words: morphological variations; Nemacheilus fasciatus; Bogor; Temanggung; Blitar   
Occurrence and habitat of softshell turtles (Testudines: Trionychidae) in Sidorejo Village, Lendah Subdistrict, Kulon Progo Regency, Special Region of Yogyakarta Province Yudha, Donan S.; Muslim, Sheliana N.
Jurnal Biologi Papua Vol 18 No 1 (2026)
Publisher : Jurusan Biologi FMIPA Universitas Cenderawasih

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31957/jbp.4888

Abstract

Softshell turtles are freshwater turtles with soft carapaces. Their habitat includes freshwater bodies such as rivers and swamps in tropical and subtropical regions. Data on softshell turtle species and their potential habitats in the freshwater ecosystems of the Special Region of Yogyakarta have not been well documented. Based on information from local residents, a softshell turtle population occurs in Sidorejo Village, Lendah, Kulon Progo, Special Region of Yogyakarta. Accordingly, this study aimed to examine the species and potential habitat of softshell turtles in Sidorejo Village, Lendah, Kulon Progo, Special Region of Yogyakarta. Sampling was conducted from 2 February to 17 April 2020 in Kedung Ingas Stream, Sidorejo Stream, and Andong Stream using the Purposive Sampling method. The results showed that the softshell turtle species found was Amyda cartilaginea. The habitat was characterized by shallow streams with depths of 20–70 cm and widths of 150–250 cm, muddy substrates with leaf litter, clear water available throughout the year, calm currents, and riparian vegetation with canopy cover such as water apple, guava, gayam, thorny bamboo, apus bamboo, and lempeni. Softshell turtle nests were characterized by their location under trees, fragments of crab shell in front of the nest cavity, small bubbles in front of the cavity, nest forms resembling cavities in soil or solid rock, and isolated nest sites. These three streams are potential habitats for softshell turtles.
Co-Authors Aphrodita, Adiva Fajar Sofyantoro Isra Wahid Muslim, Sheliana N. Nafita, Hamdani F. Nuringtyas, Tri R. Purwestri, Yekti A. Rahmi, Sri N. Sentono, Diva N. Slamet Raharjo Wahyudi, Setyanto T.