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All Journal Majalah Obat Tradisional Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Sawitri, Arinda Handiyah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Medicine & Pharmacology Public Health

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TRANSDERMAL PATCH PILIS FROM TURMERIC RHIZOME AND BLACK SEEDS FOR TREATMENT BASED ON ETHNOPHARMACY Susanto, Nindita Clourisa Amaris; Sawitri, Arinda Handiyah; Muslimah, Intan
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.4870

Abstract

Pilis, a traditional product containing various herbal ingredients, is currently less desir-able due to its impractical and unfashionable method of application. Pilis is used to treat dizziness, pain, eye fatigue, encephalitis in children, fever, and to aid recovery for mothers after childbirth. However, pilis also carries risks related to uncontrolled dosage and contamination, particularly from chemical or heavy metal pollutants, which may cause toxic reactions. To mitigate these risks, pilis should be used in recommended doses and produced under clean and safe conditions. This research aimed to provide the innovation of patches as an alternative treatment to increase attractiveness and control the active substances released and delivered for a long time. Transdermal patches are made from a combination of turmeric and black seed containing flavonoid active metabolite compounds, namely curcumin, carotenoids, quercetin, kaempferol, and apigenin. The combination has a synergistic effect that can increase total flavonoid levels and the therapeutic effect of pilis. The method used in this research was litera-ture review and data analysis. The results showed the effect of transdermal patch pilis from the combined extracts added to the formula in vitro and in vivo using animal tests. In conclusion, transdermal patch pilis has prospects as a topical treatment based on the combination of an active delivery system with a patch and metered dose system.
TRANSDERMAL PATCH PILIS FROM TURMERIC RHIZOME AND BLACK SEEDS FOR TREATMENT BASED ON ETHNOPHARMACY Susanto, Nindita Clourisa Amaris; Sawitri, Arinda Handiyah; Muslimah, Intan
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.4870

Abstract

Pilis, a traditional product containing various herbal ingredients, is currently less desir-able due to its impractical and unfashionable method of application. Pilis is used to treat dizziness, pain, eye fatigue, encephalitis in children, fever, and to aid recovery for mothers after childbirth. However, pilis also carries risks related to uncontrolled dosage and contamination, particularly from chemical or heavy metal pollutants, which may cause toxic reactions. To mitigate these risks, pilis should be used in recommended doses and produced under clean and safe conditions. This research aimed to provide the innovation of patches as an alternative treatment to increase attractiveness and control the active substances released and delivered for a long time. Transdermal patches are made from a combination of turmeric and black seed containing flavonoid active metabolite compounds, namely curcumin, carotenoids, quercetin, kaempferol, and apigenin. The combination has a synergistic effect that can increase total flavonoid levels and the therapeutic effect of pilis. The method used in this research was litera-ture review and data analysis. The results showed the effect of transdermal patch pilis from the combined extracts added to the formula in vitro and in vivo using animal tests. In conclusion, transdermal patch pilis has prospects as a topical treatment based on the combination of an active delivery system with a patch and metered dose system.
Hepatoprotective Effects of Milkfish (Chanos chanos) Oil and Silymarin Against Isoniazid–Rifampicin-Induced Liver Injury in Rats Sasongko, Heru; Hovhanness, Mikael; Sawitri, Arinda Handiyah; Maharani, Aulia Hanundita; Hedianti, Delia Putri; Hutasoit, Josua Arianto; Asyraq, Lathyfa; Safitri, Listiyana Ika; Zai, Lois Elda; Sutarno, Sutarno
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.101531

Abstract

The objectives of the present research were to assess the hepatoprotective activities of milkfish oil (MFO) and silymarin (SL) against rifampicin (RFP) and isoniazid (INH) induced hepatotoxicity. Rats were divided into seven groups: normal control, negative control (INH+RFP), silymarin alone (50 mg/kg BW/day), low-dose MFO (MFO-L), high-dose MFO (MFO-H), low-dose combination (SL+MFO-L), and high-dose combination (SL+MFO-H). Rats receiving RFP and INH showed raised liver enzymes and typical signs of hepatotoxicity. Analyzed parameters comprised proinflammatory mediators (tumor necrosis factor-alpha and interleukin-6), antioxidant markers (catalase, glutathione, malondialdehyde, and superoxide dismutase), cytochrome P450, total protein, aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin and bilirubin. Treatment with a combination of MFO plus SL remarkably decreased hepatic enzyme activities, oxidative stress and inflammation, and suggested a prevention effect against the drug-induce liver injury.
Co-Authors Asyraq, Lathyfa Hedianti, Delia Putri Heru Sasongko Hovhanness, Mikael Hutasoit, Josua Arianto Maharani, Aulia Hanundita Muslimah, Intan Safitri, Listiyana Ika Susanto, Nindita Clourisa Amaris Sutarno Sutarno Zai, Lois Elda