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Utilization of Silver Nanoparticles as Adsorbent of Methylene Blue Susanto, Nindita Clourisa Amaris; Fajri, Nadiatul; Pratama, Yoga; Prasetio, M. Reza; Rahayu, Rahayu; Hapsari, Aulia Ratri
Walisongo Journal of Chemistry Vol 6, No 2 (2023): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v6i2.18250

Abstract

This study has successfully synthesized silver nanoparticles (Ag NPs) using banana stem extract as the bioreductor and reported its application in adsorption of methylene blue (MB). Adsorption of MB was tested under ultraviolet light by varying pH solution values (3, 4, 5, 7, 9, 10, and 11), irradiation times (0,5, 1, 2, 3, 4, 5 hours), and MB concentrations (50, 100, 150, and 200 ppm) to determine their optimum values. The results revealed that the optimum pH value and irradiation time were at 9 and 1 hour, demonstrating the highest deconcentration percentage (%D) of 89.19% and 94.58%, respectively. The %D of MB dye by samples with concentrations of 50, 100, 150, and 200 ppm were 86.294%, 78.416%, 69.366%, and 66.638%, respectively, with an average of %D of 75.189%. The least degraded MB was 90.643 mg, obtained at 50 ppm. Meanwhile, the most degraded MB was 280.181 mg, attained at 200 ppm. The average concentration of degraded MB was 188.538 mg/gr.
PENGEMBANGAN PRODUK TEH HERBAL BERBAHAN DASAR TOGA BERSAMA KWT BAGAS WARAS Susanto, Nindita Clourisa Amaris; Rohmani, Sholichah; Ermawati, Dian Eka; Sasongko, Heru; Zulpadly, M. Fiqri; Utami, Diyah Tri; Meitasari, Annisa Diyah; Darojati, Ulfa Afrinurfadhilah; Untari, Meta Kartika
JCES (Journal of Character Education Society) Vol 6, No 4 (2023): Oktober
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jces.v6i4.16741

Abstract

Abstrak: Kelompok Wanita Tani (KWT) Bagas Waras merupakan kelompok produktif yang berfokus pada Tanaman Obat Keluarga (TOGA) dari pembibitan hingga pengolahan pasca panen. Kelompok Wanita Tani (KWT) Bagas Waras telah mengembangkan TOGA menjadi beberapa produk olahan makanan seperti keripik dan kue kering dan produksi dalam bentuk simplisia kering. KWT membutuhkan produk inovasi lain yang dapat mendukung dalam pengembangan pemnfaatan TOGA. Tim pengabdian memberikan transfer ilmu dalam pembuatan teh herbal untuk menjadi salah satu produk inovasi yang dapat dikembangkan oleh ibu-ibu di KWT Bagas Waras. Pelaksanaan pengabdian dilakukan dengan melibatkan ibu-ibu anggota KWT Bagas Waras sebanyak 25 orang melalui beberapa tahapan yaitu persiapan, pelatihan dan evaluasi. Kegiatan pengabdian kepada masyarakat ini diharapkan dapat mengenalkan teh herbal dengan campuran beberapa jenis TOGA dan dilakukan pengemasan dalam bentuk teh celup. Kegiatan pengabdian kepada masyarakat yaitu pelatihan pembuatan teh herbal telah terlaksana dengan baik. Kegiatan mendapatkan respon yang baik dari KWT Bagas Waras dan peserta antusias. Hasil kegiatan diperoleh 3 varian produk teh herbal dengan bahan dasar TOGA.Abstract: Bagas Waras Women Farmers Group (KWT) is a productive group that focuses on Family Medicinal Plants (TOGA) from nursery to post-harvest processing. Bagas Waras Women Farmers Group (KWT) has developed TOGA into several processed food products such as chips and pastries and production in the form of dry simplisia. KWT needs other innovative products that can support the development of TOGA utilization. The service team provided knowledge transfer in making herbal tea. The implementation of the service was carried out by involving 25 women members of KWT Bagas Waras through several stages, namely preparation, training and evaluation.. This community service activity is expected to introduce herbal tea with a mixture of several types of TOGA and packaging in the form of tea bags. Community service activities, namely training in making herbal tea, have been carried out well. The activity received a good response from KWT Bagas Waras and enthusiastic participants.
The Effect of Variation Concentration of Simplex Syrup on the Physicochemical Stability of Nanosilver Syrup Ermawati, Dian Eka; Hanuriansyah, Yavi; Susanto, Nindita Clourisa Amaris; Rochmani, Sholichah; Utami, Diyah Tri; Zulpadly, M. Fiqri; Sasongko, Heru; Darojati, Ulfa Afrinurfadhilah; Meitasari, Annisa Diyan; Untari, Meta Kartika
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 9, No 2 (2024): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v9i2.84012

Abstract

Inulin from Gembili has been identified as an effective bioreductor for forming nanosilver with a size of 481.4 nm, stable for 30 days when stored at 4°C. Inulin nanosilver exhibits immunomodulatory properties and has been proven safe through acute toxicity evaluation at a dose of 4 mg/kgBB. A drug delivery system needs to be developed for its use as a supplement. Syrup was chosen due to its alcohol-free nature, better taste, and ease of measuring the active substance compared to elixirs, solutions, and suspensions. Simplex syrupus, used as a syrup base, influences stability by potentially forming crystals during storage. This research aims to determine how varying concentrations of simplex syrupus affect the physicochemical properties of inulin nanosilver syrup. The study involved the biosynthesis process using Gembili's inulin, nanosilver characterization, formulation, and stability testing. Inulin nanosilver syrup was prepared with simplex syrupus concentrations of 20%, 40%, and 60%. The physicochemical stability of the syrup, including organoleptic properties, pH, and viscosity, was tested before and after storage at 4°C and 40°C over six cycles. The selected formula was evaluated for sugar reduction content and FT-IR profile. Data analysis was performed using SPSS 21.0 for Windows with One-way ANOVA and Paired T-Test. Results indicated that higher concentrations of simplex syrupus led to increased consistency, pH, and viscosity. A 60% concentration of simplex syrupus met the physicochemical stability requirements, with a medium-thick consistency, pH of 5.25±0.03, and viscosity of 92±2.6 cps. The reducing sugar content was 20.59% ±0.002, and the FT-IR profile confirmed the presence of inulin nanosilver, indicated by Ag-N groups compared to silver nitrate solution. This product has the potential to be developed as a health supplement.
TRANSDERMAL PATCH PILIS FROM TURMERIC RHIZOME AND BLACK SEEDS FOR TREATMENT BASED ON ETHNOPHARMACY Susanto, Nindita Clourisa Amaris; Sawitri, Arinda Handiyah; Muslimah, Intan
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.4870

Abstract

Pilis, a traditional product containing various herbal ingredients, is currently less desir-able due to its impractical and unfashionable method of application. Pilis is used to treat dizziness, pain, eye fatigue, encephalitis in children, fever, and to aid recovery for mothers after childbirth. However, pilis also carries risks related to uncontrolled dosage and contamination, particularly from chemical or heavy metal pollutants, which may cause toxic reactions. To mitigate these risks, pilis should be used in recommended doses and produced under clean and safe conditions. This research aimed to provide the innovation of patches as an alternative treatment to increase attractiveness and control the active substances released and delivered for a long time. Transdermal patches are made from a combination of turmeric and black seed containing flavonoid active metabolite compounds, namely curcumin, carotenoids, quercetin, kaempferol, and apigenin. The combination has a synergistic effect that can increase total flavonoid levels and the therapeutic effect of pilis. The method used in this research was litera-ture review and data analysis. The results showed the effect of transdermal patch pilis from the combined extracts added to the formula in vitro and in vivo using animal tests. In conclusion, transdermal patch pilis has prospects as a topical treatment based on the combination of an active delivery system with a patch and metered dose system.
Fermentation and Microencapsulation of Red Palm Oil as a Nutraceutical Source Nuralang; Ananda, Hertanti Dwi; Nelson; Susanto, Nindita Clourisa Amaris; Tarigan, Indra Lasmana
HAYATI Journal of Biosciences Vol. 32 No. 1 (2025): January 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.1.164-184

Abstract

Red palm oil (RPO) has various bioactive and nutritional components with high potential to be developed as a source of nutraceuticals in addition to its potential as a functional food. The fermentation technology is a processing process that affects metabolite activity, increasing the durability of a product. Staphylococcus epidermidis is one of the bacteria that is generally used in the sugar and oil fermentation process. RPO fermentation by Staphylococcus epidermidis is supposed to increase nutraceutical value by adding probiotic properties to RPO products. Moreover, the instability of bioactive compounds in RPO needs to be protected with coating technology microencapsulation. So, this study aims to formulate a microencapsulation procedure for fermented RPO using Staphylococcus epidermidis ATCC 12228 as a potential nutraceutical. RPO was fermented using S. epidermidis with three variations of MRS media and RPO comparison, then microencapsulated using emulsification and extrusion methods. The physicochemical properties and bioactivity of the product, microcapsule, were then analyzed. Our data shows that RPO fermentation was able to increase the chemical components. RPO fermentation produced more 1,2-Benzenedicarboxylic acid (2-Ethylhexyl) ester. Furthermore, microencapsulation of fermented RPO has better yield, efficiency, and solubility in water than non-fermented RPO microencapsulation. Moreover, our work also shows that the microencapsulation process increased RPO stability.
Hematology Toxicities in Paclitaxel-Carboplatin Cancer Regiment Meitasari, Annisa Diyan; Ermawati, Dian Eka; Rohmani, Sholichah; Sasongko, Heru; Zulpadly, Muhammad Fiqri; Utami, Diyah Tri; Susanto, Nindita Clourisa Amaris; Untari, Meta Kartika; Darojati, Ulfa Afrinurfadhilah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007064

Abstract

Chemotherapy is one of therapy for patients with cancer. Treatment carboplatin paclitaxel regimen is usually use for cervix, breast, and ovarium cancer. But the data of ADRs in hematology toxicity caused paclitaxel-carboplatin regiment is minimal, so it is required to do research. The aim of this research is can give information about the hematology toxicity, incident, severity, relationship between risk factor due incident of myelosuppression, and relationship between pre post chemotherapy due the myelosuppression. The severity ADRs use CTCAE 5.0. The ADRs were evaluated by severity, descriptive statistics, and some bivariate analysis. Anemia (66.46%) has a highest incident and followed by leukopenia (18.18%), neutropenia (13.22%), and thrombocytopenia (9.09%). Type of cancer associate with incident of anemia, leukopenia, and thrombocytopenia. The number of cycle chemotherapy use carboplatin paclitaxel regiments affects significant with the incidence of anemia. Patients who use paclitaxel-carboplatin as a regimen chemotherapy confirmed decrease in hematologic data such as hemoglobin, leukocyte, and thrombocyte.
Flavonoid Compounds from Ethanol Extract of Sungkai Leaves (Peronema canescens. Jack) and Antibacterial Activity Test Against Staphylococcus epidermidis and Escherchia coli Susanto, Nindita Clourisa Amaris; Ardhica, Jammes; Nelson; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41653

Abstract

The rise of antibiotic-resistant bacteria has intensified the global search for alternative antimicrobial agents, particularly from natural sources. Traditional medicinal plants have been widely recognized for their therapeutic potential, and Peronema canescens Jack is well-known to contain bioactive compounds. Among its pharmacological properties, its antibacterial potential has drawn scientific interest. Secondary metabolites such as flavonoids, tannins, and phenolics are believed to contribute to its antimicrobial activity. However, the specific antibacterial compounds in P. canescens remain largely unidentified. This study seeks to isolate and characterize antibacterial compounds from the ethanol extract of Sungkai leaves, aiming to discover new natural antibacterial agents. The research objectives include isolating antibacterial compounds using maceration extraction and fractionation, conducting phytochemical screening to identify metabolite classes, assessing antibacterial activity using the paper disc diffusion method, and characterizing bioactive isolates through UV-Vis spectrophotometry and FTIR analysis. The results indicate that the ethyl acetate fraction of the ethanol extract of P. canescens leaves exhibits significant antibacterial activity, particularly at concentrations of 500 and 1000 ppm. UV-Vis spectrophotometric analysis identified flavonoid compounds, including apigenin, flavones, and flavonols, based on characteristic absorption peaks. FTIR analysis confirmed the presence of functional groups associated with flavonoids, supporting their antibacterial potential. These findings highlight P. canescens as a promising source of natural antibacterial agents. Further studies focusing on compound purification and in vivo antibacterial testing are recommended to explore its pharmaceutical applications.
Cytotoxic Activity of Polymethoxyflavone Compounds Ethyl Acetate Extract of Sungkai Leaves (Peronema canescens Jack) as Anticancer Candidates Adriliana, Zairaini Adriliana; Susanto, Nindita Clourisa Amaris; Fikriansyah, Muhammad; Tarigan, Indra Lasmana; Sutrisno, Sutrisno
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41660

Abstract

Antioxidant and Antibacterial Activities of Silver Nanoparticles Biosynthesized by Leaf Foeniculum vulgare Mill. Ethanolic Extract Susanto, Nindita Clourisa Amaris; Ermawati, Dian Eka; Rohmani, Sholicha; Hanifah, Fitria Lidini; Nafisa, Fadhila Dian; Prastia, Echa Hana; Nurkhasanah, Siti; Megasari, Anis Laela; Dewi, Aptika Oktaviana Trisna
Jurnal Penelitian Pendidikan IPA Vol 11 No 6 (2025): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i6.11022

Abstract

Silver nanoparticles can be synthesized using biosynthesis methods assisted by plant extracts and can be applied as antibacterials. Hence, this study aimed to synthesize silver nanoparticles from different concentrations of AgNO3 precursor solutions using ethanol extract from fennel leaves. The influences of various AgNO3 concentrations and the volume ratios of AgNO3 solutions and leaf extracts on the activities were observed. The samples were investigated using a UV-Vis spectrophotometer, and the Surface Plasmon Resonance (SPR) absorbance was attained at 410-415 nm, representing the silver nanoparticle formation. The findings showed that the optimal ratio of precursor solution and extract was 10:1. In contrast, the optimal temperature was at 70 ° C. The size of nanoparticles was estimated using the Particle Size Analyzer (PSA), exhibiting that the different AgNO3 concentrations did not significantly change their sizes. The yields demonstrated that the antioxidant activities for nanoparticles synthesized with AgNO3 concentrations of 0.001 and 0.005 M were 153.56 ± 0.09 μg/mL and 0.005 M 111.42 ± 0.15μg/mL, respectively. The results showed higher inhibition zones of antibacterial activity obtained by silver nanoparticles with 0.005 M AgNO3 as compared to those of 0.001 M AgNO3.
Pelatihan Pembuatan Lulur Tradisional Berbahan Dasar TOGA di Kelompok Wanita Tani (KWT) Bagas Waras Boyolali: Training on Making Traditional Scrubs Based on TOGA at KWT Bagas Waras Boyolali Darojati, Ulfa Afrinurfadhilah; Rohmani, Sholichah; Sasongko, Heru; Susanto, Nindita Clourisa Amaris; Zulpadly, M. Fiqri; Utami, Diyah Tri; Meitasari, Annisa Diyan; Untari, Meta Kartika; Ermawati, Dian Eka; Artanti, Anif Nur
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 9 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i9.8562

Abstract

The Bagas Waras Women's Farmers Group (KWT) is one of the women's groups that cultivates a lot of TOGA in Banyuanyar Village, Boyolali. Their seriousness in cultivating TOGA is proven by the establishment of Omah TOGA, which has become an educational tourism destination. KWT members also have high enthusiasm for developing TOGA's potential and have produced many processed food products from TOGA. KWT Bagas Waras needs innovations in TOGA products, namely traditional cosmetic products. The service team provides scientific insight through training on developing traditional cosmetic products, namely body scrubs made from various types of TOGA. This activity involves 40 KWT members who will participate in a series of stages: preparation, training, practice, and evaluation. This training activity can increase the scientific insight of KWT members and help them develop traditional body scrubs made from TOGA and good packaging methods. This training has gone well, with all participants very enthusiastically listening to material related to traditional cosmetics and demonstrating how to make body scrubs. The results obtained are traditional body scrubs with various variants originating from TOGA.