Angin, Martinus Perangin
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Evaluasi Drug Related Problems (DRPS) Pada Pasien Di Ruang Anak Rawat Inap Di Rumah Sakit Imanuel Bandar Lampung Dengan Diagnosa Diare Saputri, Gusti Ayu Rai; Angin, Martinus Perangin; Fitriana, Ramadhani
Jurnal Ilmiah Wahana Pendidikan Vol 10 No 20 (2024): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.14457592

Abstract

Diarrhea is a disease characterized by an increase in the frequency of defecation more than 3 times a day accompanied by liquid stool consistency and accompanied by the presence or absence of blood or mucus. In the management of diarrhea in toddlers who undergo treatment, it will have an impact on the emergence of problems in drug administration Drug Related Problems (DPRs). The purpose of this study was to determine the characteristics of hospitalized pediatric patients diagnosed with diarrhea, including age, gender and weight grouping, to determine the treatment of diarrhea in pediatric patients at Imanuel Hospital Bandar Lampung in the July- Desember 2022 period including drug classes, to evaluate the management of diarrhea treatment in pediatric patients related to DRPs at the Imanuel Hospital Inpatient Installation in Bandar Lampung in the July-December 2022 period including: Drugs without indication, indication without drug, under dose and over dose. A study wasconducted on diarrhea patients in the children’s room who were treated at the Imanuel Way Halim Hospital inpatients installation from July-December 2022. With retrospective data collection techniques and descriptive analysis, a sample of 46 patients with an age range of 0-12 years was obtained. The results of data collection and processing showed that at the Imanuel Way Halim House, the most common gender was 30 men and 16 women. The most drug therapy received by diarrhea patients is zinc supplement group (71,73%) while other drugs used together with diarrhea drugs for diarrhea therapy are antidiarrheal (56,52%). The evaluation results showed that potential DPRs were drugs without indications (0,00%), indications drugs (2,17%), excessive dose (0,00%), under dose (0,00%).
Uji aktivitas antioksidan gel kombinasi ekstrak etanol daun lidah buaya (Aloevera) dan ekstrak daun kemangi (Ocimum Basillicum l) berbasis sodium alginat dengan metode DPPH Robiyun, Robiyun; Yasir, Angga Saputra; Angin, Martinus Perangin
JOURNAL OF Pharmacy and Tropical Issues Vol. 4 No. 1 (2024): June Edition 2024
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v4i1.527

Abstract

Background: Damage to the skin that causes harmful effects from the environment, such as ultraviolet rays that can cause skin damage are free radicals in the form of ultraviolet rays. Aloe vera and basil leaves contain saponins, flavonoids, phenols and tannins. This study aims to determine the antioxidant activity by knowing the IC50 value using the DPPH method. Combination of aloe vera (Aloe vera) ethanol extract gel and basil ethanol extract (Ocimum basilicum L) using an alginate base. The method used in the extraction is maceration using 96% ethanol with a yield of 19.63% aloe vera and 19.25% basil leaves. In the manufacture of a combination of aloe vera and basil leaves extract gel using a base of Sodium Alginate. The aloe vera and basil leaves extracts were applied to antioxidant activity using the DPPH method. The antioxidant activity test was carried out using the DPPH method with variations in the ratio of the extracts of the combination of aloe vera and leaves with a ratio of 1:1, 1:2 and 2:1. The IC50 value obtained is a ratio of 1:1 at 52.25 ppm, 1:2 at 41.97 ppm and 2:1 at 58.22 ppm. In the positive control of wardah's UV shield essential sunscreen gel, the IC50 value was 60.35 ppm, and the IC50 value for the negative control was 437.67 ppm. The IC50 values ​​of Gel 1:1 and 2:1 are included in the category of strong antioxidants because the IC50 values ​​are in the range of 100-150 ppm. While the 1:2 gel is included in the very strong category because the IC50 value is <50 ppm. Gel extract combination with the highest antioxidant activity was tested for gel evaluation The results of the gel evaluation test showed that the preparations of aloe vera (Aloe vera) and basil leaves (Ocimum basilicum L) extract gel preparations each met the requirements. Purpose: To determine the antioxidant activity of the combination gel of aloe vera (aloevera) and basil (Ocimum basillicum I) leaf extract based on sodium alginate using the dpph method. Method: The test equipment used was uv-vis spectrophotometry, cuvette, scale, funnel, mortar and stamp, spatula, dropper, test tube, oven, stir bar, measuring cup, dark bottle, watch glass, pH meter, spatula, aluminum foil , Erlenmeyer flasks, and glassware. Results: From the test, the results of the gel preparations of aloe vera (Aloe vera) and basil (Ocimum basilicum L) leaf extracts, each test control met the requirements. Conclusion: The gel extract combination of aloe vera and basil leaves 1:1, 1:2, and 2:1 had antioxidants of 41.97 ppm, 52.25 ppm, and 58.22 ppm, respectively. Gels 1:1 and 2:1 are included in the category of strong antioxidants because their IC50 values ​​are in the range of 100-150 ppm. While the 1:2 gel is included in the very strong category because the IC50 value is <50 ppm. The IC50 value of vitamin C as a comparison has a very strong antioxidant activity with an IC50 value of 4.75 ppm, including in the <50 ppm range. Keywords: Skin; Antioxidant; Aloe Vera; Basil Leaves; DPPH; Gel; Sodium Alginate. Pendahuluan: Kerusakan pada kulit yang menimbulkan efek berbahaya dari lingukangan, seperti sinar ultraviolet yang dapat menyebabkan kerusakan kulit adalah radikal bebas yang berupa sinar ultraviolet Daun lidah buaya dan Daun kemangi mengandung saponin, flavonoid, fenol dan tanin. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dengan mengetahui nilai IC50 menggunakan metode DPPH. kombinasi gel ekstrak etanol lidah buaya (Aloe vera) dan ekstrak etanol daun kemanangi (Ocimum basilicum L) dengan menggunakan basis alginat. Metode yang digunakan dalam ekstraksi adalah maserasi menggunakan etanol 96% dengan nilai rendemen pada lidah buaya sebesar 19,63% dan pada daun kemangi sebesar 19,25%. Pada pembuatan kombinasi gel ekstrak daun lidah buaya dan daun kemangi menggunakan basis yaitu Sodium Alginat. Dilakukan pengaplikasian ekstrak lidah buaya dan daun kemangi terhadap aktivitas antioksidan dengan menggunakan metode DPPH. Uji aktivitas antioksidan dilakukan dengan menggunakan metode DPPH dengan variasi perbandingan ekstrak kombinasi lidah buaya dan daun yang perbandingan 1:1, 1:2 dan 2:1. Nilai IC50 yang didapatkan perbandingan 1:1 sebesar 52,25 ppm, 1:2 sebesar 41,97 ppm dan 2:1 sebesar 58,22 ppm. Pada kontrol positif gel UV shield essential sunscreen wardah didapat nilai IC50 sebesar 60,35 ppm, dan nilai IC50 kontrol negatif sebesar 437,67 ppm. Nilai IC50 Gel 1:1 dan 2:1 termasuk dalam kategori antioksidan yang kuat karena nilai IC50 dalam range 100-150 ppm. Sedangkan gel 1:2 termasuk dalam kategori sangat kuat karena nilai IC50 < 50 ppm. Gel ekstrak kombinasi aktivitas antioksidan tertinggi dilakukan uji evaluasi gel Hasil uji evaluasi gel menunjukan bahwa sediaan gel ekstrak lidah buaya (Aloe vera) dan daun kemangi (Ocimum basilicum L) masing-masing evaluasi memenuhi persyaratan. Tujuan: Supaya dapat mengetahui aktivitas antioksidan gel kombinasi ekstrak etanol daun lidah buaya (aloevera)dan ekstrak daun kemangi (ocimum basillicum l) berbasis sodium alginat dengan metode dpph. Metode: Alat uji yang di gunakan spektofotometri uv-vis, kuvet, timbangan, corong, mortir dan stampel, sudip, pipet tetes, tabung reaksi, oven, batang pengaduk, gelas ukur, botol gelap, kaca arloji, pH meter, spatula, aluminium foil, labu Erlenmeyer, dan alat gelas. Hasil: Dari uji menunjukan hasil sediaan gel ekstrak daun lidah buaya (Aloe vera) dan daun kemangi (Ocimum basilicum L) masing-masing kontrol uji memenuhi persyaratan Simpulan: Gel ekstrak kombinasi daun lidah buaya dan daun kemangi 1:1, 1:2, dan 2:1 memiliki antioksidan berturut-turut 41,97 ppm, 52,25 ppm, dan 58,22 ppm. Gel 1:1 dan 2:1 termasuk dalam kategori antioksidan yang kuat karena nilai IC50 dalam range 100-150 ppm. Sedangkan gel 1:2 termasuk dalam kategori sangat kuat karena nilai IC50 < 50 ppm. Nilai IC50 vitamin C sebagai pembanding memiliki aktivitas antioksidan yang sangat kuat dengan nilai IC50 sebesar 4,75 ppm, termasuk dalam range <50 ppm. Kata Kunci : Kulit; Antioksidan; Lidah Buaya; Daun Kemangi; DPPH; Gel; Sodium Alginat