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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya
MH Faradz, Sultana
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Neuroscience Public Health

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ADVANTAGES AND DISADVANTAGES OF USING METFORMIN IN AGING RELATED DISEASES Muhammad Tola, Sakura; MH Faradz, Sultana; Handoyo Utomo, Ahmad Rusdan; Mustofa, Samsul
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.461

Abstract

This review aimed to explore the anti-aging effects of metformin, which lowers glucose, slows down cell aging through regulating intracellular signaling molecules and activating AMPK, and protects against aging-related diseases. The activation of AMPK by Metformin allows it to control inflammatory conditions, improve oxidative status, regulate differentiation pathways of various cells, and ultimately provide positive therapeutic effects on these cells. Metformin plays a role in several cardiovascular diseases, neurological disorders, cancer, and fragile X syndrome by improving several parameters in some of these disease conditions. Metformin provides benefits in aging-related diseases, but further studies with various methods and samples are needed to assess the effectiveness and consider the side effects of metformin in diabetic and non-diabetic patients, as well as involving genetic factors associated with metformin.
Co-Authors Handoyo Utomo, Ahmad Rusdan Muhammad Tola, Sakura Samsul Mustofa