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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Mutiara Medika: Jurnal Kedokteran dan Kesehatan YARSI Medical Journal Majalah Sainstekes Pena Medika : Jurnal Kesehatan Binawan Student Journal Jurnal Ilmu Medis Indonesia Seroja Husada: Jurnal Kesehatan Masyarakat Jurnal Sains, Teknologi dan Kesehatan
Samsul Mustofa
Fakultas Kedokeran Universitas YARSI
Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Prevalensi bayi lahir cacat (Malformasi Kongenital) di Rumah Sakit Pendidikan Fakultas Kedokteran Universitas YARSI Mustofa, Samsul; Susmiarsih Panjiasih, Tri; Wikaningrum, Riyani
Jurnal Kedokteran YARSI Vol 17, No 2 (2009): MEI - AGUSTUS 2009
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.263 KB) | DOI: 10.33476/jky.v17i2.203

Abstract

Congenital Malformations was instrumental in perinatal morbidity and infant mortality. Patients with severe disorders are classified to be affected physically, mentally, and socially and require special attention. Prevalence data from various types of congenital malformations may be useful to plan primary prevention measures for such disorders. The purpose of this study was to examine the prevalence of congenital malformations at the teaching hospitals, Faculty of Medicine, YARSI University. In this study, data were obtained from medical records in four teaching hospitals i.e. Abdul Muluk Hospital in Bandar Lampung, Lampung, Serang General Hospital in Serang, Banten, Garut General Hospital in Garut, and Gunung Jati General Hospital in Cirebon, West Java, within a period of three years i.e. 2005 to 2007. Based on ICD-10 codes, eight groups involving 18 types of birth defects were recorded. Among 25,276 babies born in four previously mentioned hospitals, 283 babies were born with congenital malformation. The prevalence of congenital malformations in Abdul Muluk Hospital was 11.31% with the frequency of 5.961/1,000 live birth, Serang Hospital was 13.78% with the frequency of 7.163/1,000 live birth, Garut Hospital was 33.92% with the frequency of 9.777/1,000 live birth and Gunung Jati Hospital was 40.99% with the frequency of 24.98/1000 live birth. Various disorders were noted, being the most common was disorder in the digestive system (25.80%), followed by the musculoskeletal system (20.49%), and the nervous system (16.61%). In conclusion, the total prevalence of congenital malformations in the teaching hospital, Faculty of Medicine, YARSI University was 1.12% with the frequency of 11.2/1000 live births. Congenital malformations were particularly prominent in Gunung Jati General Hospitals Cirebon, West Java.
Pengaruh Aloe Vera Terhadap Berat Badan Dan Berat Testis Rattus Norvegicus Galur Sprague Dawley Purwaningsih, Endang; Mustofa, Samsul; Riliani, Marisa
Majalah Sainstekes Vol. 10 No. 2 (2023): DESEMBER 2023
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ms.v10i2.3690

Abstract

Tanaman Aloe vera sering digunakan sebagai bahan baku kosmetik dan sebagai bahan berbagai produk kecantikan serta kesehatan. Pemberian Aloe vera dapat meningkatkan kualitas spermatozoa, berpengaruh terhadap panjang badan dan lingkar dada tetapi tidak berpengaruh terhadap ketebalan kulit. Tujuan penelitian adalah adalah mengetahui pemberian Aloe vera terhadap berat badan dan berat testis tikus galur Spraque Dawley. Metode penelitian adalah eksperimental murni. Hewan coba terbagi atas 4 kelompok, yaitu kelompok, yaitu kontrol (K) dan 3 kelompok perlakuan ekstrak Aloe vera (P1, dosis 150 mg/kgBB; PII, dosis 200 mg/kgBB, dan PIII, dosis 250 mg/kgBB), mengacu pada penelitian sebelumnya. Tikus yang digunakan memiliki berat badan antara antara 25-30 g. Pengukuran berat badan dan berat testis dilakukan setelah perlakuan selama 52 hari. Hasil penelitian menunjukkan rata -rata berat testis kanan dan kiri dari masing-masing kelompok K, PI, PII dan PIII adalah sebesar 1,2842 ±0 ,1759 g. 1,1617 ± 0,2421 g , 1,0608 ± 0,2368 g dan 1,0317 ± 0,2940 g. Sedangkan berat badan setelah perlakuan masing-masing kelompok K, PI, PII dan PIII adalah sebesar 251,33 ± 36,351 g; 245,83 ± 23,659 g; 260,17 ± 25,748 g, dan 262,33 ± 29,317 g. Disimpulkan bahwa pemberian Aloe vera dosis 150 -250 mg/kkBB selama satu siklus epitel seminiferus tidak berpengaruh terhadap berat badan dan berat testis.
Peran Sekuens Genom Mitokondria dan Susunan Gen Sarcoptes Scabiei terhadap Karakterisasi Genetik Pasien Terinfestasi Skabies Trasia, Reqgi First; Mustofa, Samsul; Purwaningsih, Endang; Herlinawati, Sri Wahyu
Jurnal Ilmu Medis Indonesia Vol. 3 No. 2 (2024): Maret
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jimi.v3i2.3110

Abstract

Purpose: The aim of writing this article is to examine the draft genome of S. scabiei from a number of published articles Research methodology: This article reviews scabies genome sequencing, which may provide the necessary facilities to investigate the many unknowns associated with the survival of scabies mites. Results: Scabies genome sequencing investigated many unknowns related to scabies mite survival, reproduction, and host-parasite interactions and may facilitate studies in the areas of developing scabies diagnostic tests, new treatments, and vaccines to protect against this disease. Limitations: From the results of sequencing, assembly, and annotation of the scabies mite mitochondrial genome, the experts identified SNPs in several isolates from patients and laboratory pig models and inferred the haplotype structure and diversity of individual infections. Contribution: The results of multi-locus studies in a number of countries indicate that different varieties of Sarcoptes mites originate from different host species and geographic regions and recommend a common gene pool of S. scabiei that represents the existence of a single species.
Effects of Green Tea Leaf Extract on Viability, Apoptosis, and Expression of Interleukin-6 in Keloid Fibroblasts Fasihah, Mariah Shofwah; Hadi, Restu Syamsul; Mustofa, Samsul
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 1 (2024): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i1.20146

Abstract

Green tea leaf (Camellia sinensis) extract contains polyphenols, anti-inflammatory and anti-carcinogenic agents that may effectively to as keloid therapy. This study aims to examine the effect of green tea leaf extract on viability, apoptosis, and interleukin-6 expression in keloid fibroblasts. Keloid fibroblast cultures were divided into groups that were cultivated with green tea extract at dosages of 100, 200, 400, and 800 μg/mL, negative control (10% Fetal Bovine Serum/FBS), and positive control (100 μM dexamethasone). This study used post-test-only control group design. The highest mean IL-6 expression was in the GTE 200 (275,942.7 pg/mL), while the lowest was in the GTE 800 ( -2,890.6 pg/mL). The viability and apoptosis was analized by using one-way ANOVA, continued with Least Significant Difference (LSD) with a significance of p 0.05 in the GTE 800 treatment group compared to the entire intervention group. Kruskal-Wallis followed by a Mann-Whitney was carried out for interleukin-6 (IL-6) with a significance of p 0.05 in the extract therapy group at dosages of 200, 400, 800 μg/ml and 100 μM dexamethasone. In conclusion, green tea leaf extract at 800 μg/ml could reduce viability interleukin-6 expression and increase apoptotic caspase-3 expression in keloid fibroblast cells.
ASPEK NEUROSAINS DALAM PATOFISIOLOGI PRURITUS NOKTURNAL Trasia, Reqgi First; Mustofa, Samsul; Purwaningsih, Endang; Herlinawati, Sri Wahyu
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 1 No. 2 (2024): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Juni 2024
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/2cyt9p58

Abstract

Itching at night in scabies patients is considered a very disturbing symptom. It is known that the main role of the itch sensation and subsequent motor response is to remove environmental influences from the skin, especially arthropods. The purpose of this article is to provide an understanding of the overall physiology and associated pathophysiology of itch. This article focuses on the neuronal aspect, as the nervous system is necessary to perceive the sensation of itch, as well as the multidirectional connections between the nervous and immune systems that influence the transmission of itch from the skin to the spinal cord. Itching is felt by skin nerve fibers called pruriceptors. These primary afferent fibers function as antennae and continuously sense the skin environment to detect and respond to cues. All major afferents project to the dorsal part of the spinal cord. Peptidergic and nonpeptidergic neurons target different areas of the dorsal superficial lamina. Based on this review, it can be concluded that noxious and pruritic stimuli are mostly processed in the superficial dorsal horn, whereas deeper dorsal horn neurons receive nociceptive and pruritic input via polysynaptic innervation.
HUBUNGAN PENGETAHUAN IBU TENTANG POLA PEMBERIAN MAKAN KEPADA BALITA USIA 12-59 BULAN DENGAN KEJADIAN STUNTING DI POSYANDU CEMPAKA RW 07 KELURAHAN KALISARI KECAMATAN PASAR REBO JAKARTA TIMUR DAN TINJAUANNYA MENURUT PANDANGAN ISLAM Ghasani, Almas Sabrina; Mustofa, Samsul; Afrizal, Afrizal; Purwaningsih, Endang
Seroja Husada: Jurnal Kesehatan Masyarakat Vol. 1 No. 7 (2024): Seroja Husada: Jurnal Kesehatan Masyarakat
Publisher : Seroja Husada: Jurnal Kesehatan Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.572349/serojahusada.v1i7.4732

Abstract

Peran ibu merupakan hal dasar yang penting terhadap pertumbuhan dan perkembangan pada anak sejak dalam masa kandungan sampai dewasa. Pemberian asupan gizi dan nutrisi yang tidak seimbang dapat menyebabkan terjadinya gangguan pertumbuhan pada anak yaitu stunting. Tujuan penelitian ini adalah Untuk mengetahui pengaruh pengetahuan ibu terhadap pemberian makanan yang bergizi kepada anak terhadap kejadian stunting di Posyandu Cempaka RW 07 Kelurahan Kalisari Kecamatan Pasar Rebo, Jakarta Timur. Penelitian ini menggunakan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh ibu yang memiliki balita di Posyandu Cempaka RW 07 Kelurahan Kalisari, Kecamatan Pasar Rebo, Jakarta Timur sebanyak 30 orang. Teknik pengambilan sampel menggunakan metode purposive sampling. Hasil penelitian menunjukkan bahwa sebagian besar sebagian besar ibu di Posyandu Cempaka memiliki pengetahuan yang tepat terhadap pola pemberian makanan pada balita yaitu sebanyak 20 orang (66,67%) dan kejadian stunting pada balita sebanyak 4 orang (13,3%). tidak terdapat hubungan signifikan antara tipe pola makan dengan status stunting dengan nilai p sebesar 0,704. Hak anak terhadap gizi untuk mencegah stunting adalah dengan memberikan asupan gizi yang cukup seperti memberikan ASI sampai anak berusia 2 tahun dan memberikan makanan yang bernutrisi untuk anak. Dalam pandangan Islam orang tua memiliki tanggung jawab dan kewajiban untuk memenuhi segala kebutuhan anak terutama dalam kebutuhan asupan gizi yang seimbang terutama dalam menyediakan makanan yang halal dan thayyib. Diharapkan dengan adanya penelitian ini dapat meningkatkan kesadaran ibu terhadap pentingnya pemberian gizi seimbang dengann cara menentukan jenis makanan, jumlah makanan, dan jadwal makanan sesuai dengan kebutuhan anak sesuai usianya.
Pemeriksaan Laboratorium Sebagai Penegak Diagnosis Penyakit Malaria: Literature Review: Laboratory Examination as a Diagnosis Confirmation for Malaria Disease: Literature Review Aryani, Desi; Mustofa, Samsul; Utomo, Ahmad Rusdan Handoyo; Lardo, Soroy
Binawan Student Journal Vol. 6 No. 3 (2024)
Publisher : Direktorat Penelitian, Pengabdian Masyarakat, Dan Kerjasama Universitas Binawan (DPPMK Universitas Binawan)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54771/sbnfrv55

Abstract

Malaria adalah infeksi parasit protozoa dari genus Plasmodium yang menyerang sel darah merah. Kasus  malaria banyak ditemukan di wilayah subtropis dan tropis dan dapat mengakibatkan kematian.  Penegakan diagnosis malaria perlu diperhatikan untuk melihat keakuratan metode yang digunakan guna mencegah terjadinya kesalahan dalam pemeriksaan laboratorium. Metode yang dapat digunakan dalam deteksi malaria yaitu dengan pemeriksaan mikroskopis, Polymerase Chain Reaction (PCR), dan Rapid Diagnostic Test (RDT). Kombinasi dari berbagai metode dapat meningkatkan akurasi diagnosis malaria. Penulisan artikel ini bertujuan untuk mengkaji peran berbagai metode pemeriksaan laboratorium dalam mendeteksi malaria dan menganalisis perbandingan metode mikroskopis, PCR dan RDT.
ADVANTAGES AND DISADVANTAGES OF USING METFORMIN IN AGING RELATED DISEASES Muhammad Tola, Sakura; MH Faradz, Sultana; Handoyo Utomo, Ahmad Rusdan; Mustofa, Samsul
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.461

Abstract

This review aimed to explore the anti-aging effects of metformin, which lowers glucose, slows down cell aging through regulating intracellular signaling molecules and activating AMPK, and protects against aging-related diseases. The activation of AMPK by Metformin allows it to control inflammatory conditions, improve oxidative status, regulate differentiation pathways of various cells, and ultimately provide positive therapeutic effects on these cells. Metformin plays a role in several cardiovascular diseases, neurological disorders, cancer, and fragile X syndrome by improving several parameters in some of these disease conditions. Metformin provides benefits in aging-related diseases, but further studies with various methods and samples are needed to assess the effectiveness and consider the side effects of metformin in diabetic and non-diabetic patients, as well as involving genetic factors associated with metformin.
Protein Tungau Sarcoptes Scabiei Sebagai Penyebab Stres Oksidatif Pada Kulit yang Terinvestasi Parasit Trasia, Reqgi First; Mustofa, Samsul; Purwaningsih, Endang; Herlinawati, Sri Wahyu
Pena Medika : Jurnal Kesehatan Vol. 15 No. 1 (2025): PENA MEDIKA: JURNAL KESEHATAN
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

S. scabiei infestation triggers many reactions including allergic reactions, inflammation, innate immune reactions, and activation of immune components in the skin accompanied by oxidative stress stages. This article aims to examine the genetic characterization of S. scabiei and gain a better understanding of host-parasite interactions with particular emphasis on skin oxidative stress parameters such as oxidant/antioxidant balance, stress parameters, and immune responses. This article is compiled as a systematic review by examining a number of relevant publications. Based on this search, it was found that to determine the effect of S. scabiei infestation on the oxidant/antioxidant balance in serum, oxidative stress markers such as total antioxidant activity (T-AOC), total nitric oxide concentration (TNO), lipid peroxide levels, and malonyldialdehyde (MDA) were used, as well as antioxidant enzyme levels; superoxide dismutase (SOD), glutathione-S-transferase (GSH) and catalase. Oxidative stress has been shown to be involved in the pathogenesis of several parasitic infectious diseases including scabies. Host cell metabolism produces ROS and RNS. At low to moderate levels, they are involved in several physiological functions including cell signaling and immune function. Conversely, at high levels, they cause damage to molecules including lipids, proteins, lipoproteins, and nucleic acids starting from a chain reaction of free radical formation leading to a condition known as oxidative stress. This article recommends a meta-analysis study to obtain more in-depth review results for further research..
Co-Authors - Afrizal desi aryani Endang Purwaningsih Fasihah, Mariah Shofwah Ghasani, Almas Sabrina Handoyo Utomo, Ahmad Rusdan MH Faradz, Sultana Muhammad Tola, Sakura Reqgi First Trasia Restu Syamsul Hadi Riliani, Marisa Soroy Lardo Sri Wahyu Herlinawati Susmiarsih Panjiasih, Tri Utomo, Ahmad Rusdan Handoyo Wikaningrum, Riyani