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All Journal Journal of Pharmaceutical and Sciences. Usadha Journal of Pharmacy Journal of Nutraceuticals and Herbal Medicine
Fahmi, Muhammad Zaini
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Antiobesity Activity Of A Combination Of Extracts From Porang Tubers ( Amorphopallus Muelleri ) and Jati Belanda Leaves ( Guazuma Ulmifolia ) In Obesity Rat Models Fahmi, Muhammad Zaini; Muhtadi; Hidayatullah, Muhammad Haqqi
Journal of Nutraceuticals and Herbal Medicine Vol 5, No 1 (2024): JNHM 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v5i1.3703

Abstract

Obesity is an excessive accumulation of fat due to an imbalance in energy intake with energi expenditure for a long time. Obesity can be reduced by taking drugs. One of the commonly used herbal medicines for obesity is porang tubers and Dutch teak plants. The purpose of this study was to prove the anti-obesity activity of the combination of porang tuber extract with Dutch teak leaf extract in obese rat models. Anti-obesity effect test was carried out for 14 days on obese rats. The antiobesity effect was assessed by the index Lee ≥ 0,3 and weight loss. This study was conducted using 5 groups of test animals, namely the negative group (PGS 1%), positive (orlistat 7.57 mg/kgBW), and 3 groups of a combination of porang tuber extract and Dutch teak leaves, 50 + 62.5; 50 + 125; 50 + 250 mg/kgBW. Weight loss occurred in groups II, IV,and V, in groups I there was an increase in body weight. The mean results of the Lee index of groups I, II, III, IV, and V were 0,31 ± 0,02, 0,29 ± 0,01, 0,29 ± 0,01, 0,29 ± 0,01, and 0,30 ± 0,01. Data analysis using the Kruskall-Wallis test resulted in no significant difference of 0.715 (p>0.05) on day 14 which showed that the combination of porang tubers and Dutch teak leaves had no anti-obesity effect.
Drug-Related Problems Pada Penyakit Paru Obstruksi Kronis: Literatur Review Fahmi, Muhammad Zaini; Karuniawati, Hidayah; Ismail, Wan Ismahanisa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.955

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of global morbidity and mortality, with a continuously increasing health burden. The complexity of long-term therapy in COPD increases the risk of Drug-Related Problems (DRPs), which can affect patient clinical outcomes. This literature review was conducted descriptively by searching articles in the PubMed, Scopus, Google Scholar, and ScienceDirect databases using keywords related to DRPs and COPD. The selection was made on publications from the last 10 years (2015–2025) relevant to the topic and available in full text. Based on studies by Li et al., (2019) and Apikoglu-Rabus et al., (2016), the classification of DRPs according to PCNE V9.0 mainly included aspects of medication safety (54.2%), inappropriate drug selection (up to 8.7%), excessive dosage (19.9%), excessive duration of therapy (17.7%), and errors in the drug use process (up to 63.3%). Patient factors such as non-compliance (25%) and incorrect inhalation techniques were the main contributors to the occurrence of DRPs. Inappropriate use of medications, drug-herb interactions, and lack of therapy monitoring were also consistently found. The findings suggest that DRPs significantly worsen symptom control and increase the risk of exacerbations. Pharmacists are critical in identifying, preventing, and managing DRPs through patient education, therapy review, and ongoing therapy monitoring. DRPs in COPD patients are a serious challenge that requires a multidisciplinary approach. Ongoing education, monitoring of therapy rationality, and collaboration between healthcare professionals are needed to improve patient safety and the effectiveness of COPD treatment.
AKTIVITAS ANTIOBESITAS KOMBINASI EKSTRAK DARI UMBI PORANG (Amorphopallus muelleri) DAN JATI BELANDA (Guazuma ulmifolia) PADA MODEL TIKUS OBESITAS Fahmi, Muhammad Zaini; Muhtadi, Muhtadi
Usadha Journal of Pharmacy Vol. 1 No. 3 (2022): Agustus
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v1i3.95

Abstract

Obesitas merupakan penumpukan lemak yang berlebihan akibat ketidak seimbangan asupan energi dengan energi yang digunakan dalam waktu lama .Obesitas, dapat dikurangi dengan mengkonsumsi obat-obatan. Obat-obatan berasal dari bahan sintetik (kimia) dan bahan tradisional (herbal). Salah satu obat herbal yang umum digunakan untuk obesitas adalah umbi porang dan tanaman jati belanda. Tujuan penelitian ini adalah. membuktikan pengaruh pemberian kombinasi ekstrak umbi porang dengan ekstrak daun jati belanda memiliki aktivitas anti-obesitas pada model tikus obesitas. Induksi obesitas dilakukan melalui pemberian pakan lemak tinggi selama 21 hari pada semua kelompok. Terjadinya kondisi obesitas pada hewan uji dinilai dari nilai Indeks Lee ˃ 0,3. Uji efek antiobesitas dilakukan selama 14 hari pada tikus model obesitas. Efek antiobesitas dinilai dari indeks Lee dan penurunan berat badan. Penelitian ini dilakukan dengan menggunakan 6 kelompok hewan uji, terdiri dari kelompok negatif, positif dan 4 perlakuan kelompok hewan uji. Penurunan berat badan terjadi pada kelompok II, IV, V, dan VI, pada kelompok I dan III terjadi peningkatan berat badan.  Hasil rata-rata indeks Lee kelompok I, II, III, IV,V,VI berturut-turut adalah  0,31± 0,02; 0,29 ± 0,01; 0,29 ± 0,01; 0,29 ± 0,01; dan 0,30 ± 0,01. Data dianalisis menggunakan uji One way ANOVA menunjukkan pada hari ke-14 memperoleh nilai signifikansi 0,038 (p<0,05) yang artinya memiliki perbedaan bermakna pada masing-masing perlakuan.  
Co-Authors Hidayah Karuniawati Ismail, Wan Ismahanisa Muhammad Haqqi Hidayatullah Muhtadi Muhtadi Muhtadi