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All Journal Pharmacon JPSCR : Journal of Pharmaceutical Science and Clinical Research JOURNAL LA MEDIHEALTICO Abdi Geomedisains Prosiding University Research Colloquium Prosiding Seminar Nasional Pengabdian Masyarakat Usadha Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Nutraceuticals and Herbal Medicine Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia Jurnal Pengabdian Masyarakat Inovasi Indonesia
Muhammad Haqqi Hidayatullah
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Pengembangan Dan Validasi Metode Analisis Amlodipin Besilat Dan Cemarannya Dalam Sediaan Tablet Muhammad Haqqi Hidayatullah; Slamet Ibrahim; Benny Permana
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 2 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i2.20210

Abstract

Amlodipine besylate belongs to the class of oral dihydropyridine calcium channel blockers that can be used to hypertension and angina therapy. Amlodipine as a pharmaceutical preparation must meet the criteria for a good pharmaceutical preparation, namely safe, efficacious and quality. In terms of safety, the presence of organic impurity in pharmaceutical products can affect the safety of medicinal products. Because the difficultness to obtain a standard of impurity, it is necessary to develop an analytical method to analyze the presence of contamination by stress testing. The analytical method was developed using a High Performance Liquid Chromatography (HPLC) instrument with Eclipse Plus C18 column 5 m (150 x 4.6 mm), mobile phase triethylamine (TEA): methanol in a ratio of 40:60 with isocratic elution and a flow rate of 1 mL/minutes and a wavelength of 237 nm with an injection volume of 10 µL. The results of the method validation showed good linearity with R2 of 0.9996, detection limit of 18.46 µg/mL and quantization limit value of 61.54 µg/mL. The value of the coefficient of variation on the precision parameter is 1.18-1.26%. The percent recovery accuracy value is 93.07-105.44% and the range value for proportional samples is in the concentration range of 24-84 µg/ml with R2 = 0.9993. The HPLC system meets all requirements for acceptance of the system conformity test. The results of this experiment showed that there were 2 out of 5 peaks of degradation products whose chemical structure was known. The application of the analytical method on commercial samples showed levels between 90.79-95.68% and there was no impurity in the product samples.
Determination of Total Phenolic Content in Muntingia Calabura L. Extract and Antioxidant Activity Test Using the Ferric Reducing Antioxidant Power Method Palupi, Ajeng Sekar; Hidayatullah, Muhammad Haqqi
Journal La Medihealtico Vol. 5 No. 3 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i3.1350

Abstract

Natural antioxidants can be obtained from fruit, vegetables and plants, because they contain the largest compounds, namely phenolic compounds. Phenolic compounds are the largest group of compounds that function as natural antioxidants in plants. One plant that contains a lot of antioxidants is found in the cherry plant (Muntingia calabura L.). This study aims to determine the total phenolic content and antioxidant activity of the maceration and ultrasonic extraction methods of ethanol extract, ethyl acetate of cherry leaves (Muntingia calabura L.). Extraction of cherry leaves was carried out using maceration and ultrasonic methods using ethyl acetate solvent. The thick ethyl acetate and ethanol extracts of cherry leaves were measured for total phenolic content and antioxidant activity. The results of maceration extraction with ethanol solvent had a content of 58.498 mgGAE/g and ethyl acetate had a content of 58.820 mgGAE/g. The results of ultrasonic extraction with ethanol solvent had a content of 56.118 mgGAE/g and ethyl acetate had a content of 51.463 mgGAE/g. The total phenolic content of ethanol and ethyl acetate extracts of cherry leaves from the maceration and ultrasonic methods had significant differences. Ethanol and ethyl acetate extracts of cherry leaves using the maceration extraction method had antioxidant activity levels of 36,639 ppm and 39,361 ppm, while the ultrasonic method had antioxidant activity levels of 35,268 ppm and 39,179 ppm respectively. The antioxidant activity of ethanol and ethyl acetate extracts of cherry leaves from maceration and ultrasonic extraction methods has significant differences.
Edukasi Penanganan Limbah Obat dan Limbah B3 Di Kelompok PKK Gonggangan, Bolon, Colomadu, Karanganyar Fauzi, Ahmad; Saifudin, Azis; Hidayatullah, Muhammad Haqqi; Ramadhan, Muhammad Reza; Kholifatul Hakimah, Wafiq; Mufidah Maulina, Fariha
Abdi Geomedisains Vol. 5, No. 2, December 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/abdigeomedisains.v5i2.6968

Abstract

The management of hazardous and toxic waste (B3) and household pharmaceutical waste is a critical issue due to its adverse effects on human health and the environment. B3 waste, such as used batteries, light bulbs, spent oil, and aerosol cans, poses a significant risk of contaminating soil, water, and air if not properly managed. Pharmaceutical waste, including expired or damaged medications, also has the potential to harm public health. Improper disposal can lead to pollution, causing acute health problems such as neurological damage and respiratory disorders, as well as long-term risks such as cancer and genetic mutations. To address this issue, an community program was conducted for the community in Dusun Gonggangan, Bolon, Colomadu, Karanganyar, involving the local women's community group (PKK). The method employed consisted of education through presentations and interactive Q&A sessions. The materials covered waste identification, segregation, storage, and disposal according to proper waste management standards. Interactive discussions encouraged active community participation to understand and adopt responsible household waste management practices. The results showed an increase in community awareness regarding the proper management of B3 and household pharmaceutical waste. The implementation of appropriate waste management practices is expected to mitigate the negative impacts of waste on health and the environment. Thus, effective waste management contributes to improved public health and supports environmental sustainability and ecosystem preservation.
Antiobesity Activity Of A Combination Of Extracts From Porang Tubers ( Amorphopallus Muelleri ) and Jati Belanda Leaves ( Guazuma Ulmifolia ) In Obesity Rat Models Fahmi, Muhammad Zaini; Muhtadi; Hidayatullah, Muhammad Haqqi
Journal of Nutraceuticals and Herbal Medicine Vol 5, No 1 (2024): JNHM 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v5i1.3703

Abstract

Obesity is an excessive accumulation of fat due to an imbalance in energy intake with energi expenditure for a long time. Obesity can be reduced by taking drugs. One of the commonly used herbal medicines for obesity is porang tubers and Dutch teak plants. The purpose of this study was to prove the anti-obesity activity of the combination of porang tuber extract with Dutch teak leaf extract in obese rat models. Anti-obesity effect test was carried out for 14 days on obese rats. The antiobesity effect was assessed by the index Lee ≥ 0,3 and weight loss. This study was conducted using 5 groups of test animals, namely the negative group (PGS 1%), positive (orlistat 7.57 mg/kgBW), and 3 groups of a combination of porang tuber extract and Dutch teak leaves, 50 + 62.5; 50 + 125; 50 + 250 mg/kgBW. Weight loss occurred in groups II, IV,and V, in groups I there was an increase in body weight. The mean results of the Lee index of groups I, II, III, IV, and V were 0,31 ± 0,02, 0,29 ± 0,01, 0,29 ± 0,01, 0,29 ± 0,01, and 0,30 ± 0,01. Data analysis using the Kruskall-Wallis test resulted in no significant difference of 0.715 (p>0.05) on day 14 which showed that the combination of porang tubers and Dutch teak leaves had no anti-obesity effect.
Optimasi Metode Ekstraksi Albumin Dari Ikan Gabus (Channa striata) Muhammad Haqqi Hidayatullah; Munawwarah Munawwarah; Andi Suhendi
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 3 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i3.66952

Abstract

Ikan gabus (Channa striata) memiliki kadar protein yang tinggi dengan kandungan utamanya adalah albumin. Sehingga diperlukan metode dan kondisi ekstraksi yang sesuai agar mendapatkan rendemen dan kandungan albumin yang optimal. Penelitian ini bertujuan untuk mendapatkan metode ekstrkasi yang optimal antara perebusan biasa, microwave-assisted extraction (MAE) dan ultrasonic-assisted extraction (UAE) dengan parameter kadar albumin. Ekstraksi dilakukan dengan perbandingan daging ikan gabus dan akuades (1 : 1). Variasi waktu ekstraksi yaitu 5, 10 dan 15 menit. Kadar albumin ditetapkan dengan metode Lowry. Rendemen ekstrak yang dihasilkan dari 3 metode ekstraksi pada waktu ekstraksi 5 menit berurutan 2,419; 1,293 dan 1,575 %b/b. Kurva baku Albumin didapatkan persamaan regresi linier yaitu y = 3,38x + 0,7396 dengan nilai r = 0,997. Kadar albumin yang diperoleh dari 3 metode ekstraksi pada waktu ekstraksi 10 menit secara berurutan adalah 47,009 + 1,046; 44,792 + 5,372 dan 28,946 + 2,260 %b/b. Berdasarkan data tersebut, metode ekstraksi yang memberikan kadar albumin yang terbesar adalah metode perebusan dengan waktu 10 menit.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN KERSEN (Muntingia calabura L.) HASIL MASERASI DAN UAE (ULTRASONIC ASSISTED EXTRACTION) DENGAN METODE DPPH (2,2-DIFENIL-1-PIKRILHIDRAZIL) Nindyasari, Asyifa; Hidayatullah, Muhammad Haqqi
Usadha Journal of Pharmacy Vol. 3 No. 4 (2024): November
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v3i4.424

Abstract

Antioksidan merupakan senyawa yang dapat menetralisir masalah radikal bebas. Tanaman kersen diketahui merupakan tanaman yang berkhasiat sebagai antioksidan alami yang biasa digunakan masyarakat sebagai obat tradisional. Salah satu senyawa yang terkandung dalam tanaman kersen adalah flavonoid. Flavonoid merupakan senyawa antioksidan terbesar yang dapat mencegah kerusakan yang diakibatkan oleh radikal bebas. Penelitian ini bertujuan untuk membandingkan dua metode ekstraksi maserasi dan UAE dengan pelarut etanol dan n-heksana menggunakan metode DPPH yang akan dibaca menggunakan alat spektrofotometer UV-Vis dengan harapan diperoleh perbandingan kadar aktivitas antioksidan dari daun kersen dan mengidentifikasi kandungan flavonoid total. Hasil penelitian uji flavonoid total dan pengujian aktivitas antioksidan dengan ekstrak etanol metode maserasi menghasilkan kadar flavonoid total sebesar 3,007 mgQe yang menandakan adanya kadar flavonoid yang tinggi dan pada aktivitas antioksidan memiliki kemampuan antioksidan yang sangat tinggi dengan nilai IC50 22,501 ppm. Namun, berbanding terbalik dengan hasil total flavonoid ekstrak n-heksan metode UAE sebesar 0,454 mgQe yang menandakan kadar flavonoid total lebih sedikit dan memiliki aktivitas antioksidan yang rendah dengan nilai IC50 69,065 ppm. 
VALIDASI METODE ANALISIS PARACETAMOL DAN ASAM MEFENAMAT DALAM JAMU PEGAL LINU DENGAN METODE SPEKTROFOTOMETRI UV SIMULTAN Rachmawati, Fiony Diva; Hidayatullah, Muhammad Haqqi
Usadha Journal of Pharmacy Vol. 4 No. 1 (2025): Februari
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v4i2.528

Abstract

Jamu sebagai obat tradisional banyak dimanfaatkan oleh masyarakat untuk mencegah atau mengobati berbagai macam penyakit. Namun, tingginya minat masyarakat terhadap jamu sering dimanfaatkan secara tidak etis oleh produsen dengan menambahkan Bahan Kimia Obat (BKO) untuk meningkatkan penjualan karena diyakini dapat memberikan efek lebih cepat. Penelitian ini bertujuan untuk memvalidasi metode analisis bahan kimia obat pada jamu pegal linu. Analisis kualitatif dilakukan dengan metode kromatografi lapis tipis sedangkan analisis kuantitatif memanfaatkan metode spektrofotometri UV secara simultan. Standar yang digunakan dalam penelitian adalah parasetamol dan asam mefenamat. Fase diam yang digunakan silika GF254 dan fase gerak yang digunakan kloroform : etanol 96% (9:1). Validasi metode analisis melibatkan empat parameter yaitu linieritas, presisi, batas deteksi, dan batas kuantitasi. Hasil penelitian menunjukkan bahwa analisis kualitatif dengan kromatografi lapis tipis mendeteksi keberadaan bahan kimia asam mefenamat di semua sampel dan sampel C, D, I, dan J mengandung bahan kimia parasetamol, sedangkan analisis kuantitatif dengan spektrofotometri UV simultan menghasilkan parameter validasi seperti linearitas, akurasi, presisi, dan kadar yang memenuhi syarat. Pada penetapan kadar menunjukkan bahwa kadar parasetamol dan asam mefenamat yang tertinggi adalah sampel G yaitu 0,570% b/b dan 0,684% b/b.
EXTRACT AND FRACTIONS EXPLORATION OF DAYAK ONION (Eleutherine America-na Merr.) WITH ANTIOXIDANTS POTENTIAL USING GC-MS and FTIR METHODS Elisa, Novi; Advistasari, Yustisia Dian; Lepangkari, Jaka Seprianto; Hidayatullah, Muhammad Haqqi
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9209

Abstract

Free radicals can cause various diseases in the body if not treated immediately. Large levels of free radicals may trigger damage to normally functioning tissues, lipid layers, blood vessels, DNA synthesis disturbances, and even destruction of cells. The objective is to evaluate the antioxidants potential of dayak onion extract and fractions. FTIR spectrophotometers, gas chromatography-mass spectrometry (GC-MS) and an antioxidants multimode reader are some of the research methods. The outcomes of this research are identifying plants that showed the dayak onion extract of the species Eleutherine Americana Merr. It contains compounds such as flavonoids, alkaloids, tannins, and saponins. In addition, the components found in the extract, water fraction, ethyl acetate fraction, and n-hexane fraction are octadecanoic acid 298 m/z, 9-octadecanoic acid 282 m/z, undecanoic acid 214 m/z, hexadecanoic acid 368 m/z, and nonadecanoic acid 326 m/z. Therefore, the antioxidants test using the DPPH method showed that the best IC50 value is for ethyl acetate with IC50 20.56 ppm.
FORMULATION AND EVALUATION OF GOLDEN SEA CUCUMBER (STICHOPUS HERRMANNI) ORAL SUSPENSION Fauzi, Ahmad; Santoso, Broto; Hidayatullah, Muhammad Haqqi; Zafarani Azzuhra, Alifia; Ahsaninnisa, Azizah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1683

Abstract

The Golden Sea Cucumber (Stichopus herrmanni) is widely recognized for its high protein and collagen content, making it valuable for medicinal applications, such as wound healing and tissue regeneration. The present study focused on formulating an oral suspension of sea cucumber extract, assessing its stability, and determining its protein content. Extraction was performed using a boiling method with distilled water to yield a protein-rich extract, which was then formulated into four suspension formulas (Formula 1, 2, 3, and 4) using pharmaceutical-grade excipients, including sorbitol, sodium CMC, and sodium benzoate. Protein quantification was conducted using the Biuret method with Bovine Serum Albumin (BSA) as a standard and analyzed using UV-Vis spectrophotometry. Stability testing over 1, 3, and 6 months was used to evaluate pH, viscosity, and sensory characteristics (odor, color, and taste). Among the four formulations, formula 4 demonstrated the highest stability, maintaining optimal homogeneity, sensory attributes, and pH, along with the highest protein concentration (8.10 mg/mL. These results highlight Formula 4 as the most promising because of its superior stability and protein content. This study underscores the challenges of long-term stability in protein-based suspensions, suggesting the need for further research into advanced excipient selection and encapsulation techniques to protect sensitive proteins. Overall, this research supports the potential use of marine-derived bioactive compounds in pharmaceutical applications, paving the way for sustainable healthcare and cosmetic products. Keywords: golden sea cucumber, Stichopus herrmanni, oral suspension formulation, stability test
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP Bacillus cereus DAN Shigella sonnei SERTA BIOAUTOGRAFINYA Hidayah, Ariesta Adriena Putri; Hidayatullah, Muhammad Haqqi
Usadha Journal of Pharmacy Vol. 4 No. 3 (2025): Agustus
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v4i4.700

Abstract

Penyakit diare merupakan permasalahan yang utama di seluruh dunia, termasuk di Indonesia. Diare dapat disebabkan oleh infeksi bakteri seperti bakteri Bacillus cereus dan Shigella sonnei. Daun kersen memiliki potensi sebagai antibakteri, sehingga bisa mencegah penyakit diare. Penelitian ini memiliki tujuan untuk mengetahui aktivitas antibakteri serta golongan senyawa aktif ekstrak etanol daun kersen (Muntingia calabura L.)  terhadap bakteri Bacillus cereus dan Shigella sonnei. Ekstrak diperoleh dari hasil maserasi dengan etanol 70% kemudian dibuat seri konsentrasi 25%, 50%, 75%, dan 100%. Metode difusi disk digunakan untuk uji aktivitas antibakteri dengan kontrol positif yaitu siprofloksasin sedangkan kontrol negatif menggunakan DMSO. Seri konsentrasi 100% memiliki aktivitas antibakteri yang paling kuat  terhadap bakteri Bacillus cereus dan Shigella sonnei dengan zona hambat 10,0 mm dan 9,6 mm. Identifikasi golongan senyawa daun kersen menggunakan metode KLT dengan fase diam silika gel GF254 dan kloroform : metanol (9:1 v/v) sebagai fase gerak. Hasil identifikasi senyawa dalam ekstrak etanol daun kersen merupakan flavonoid, alkaloid, tanin, steroid. Hasil bioautografi menunjukkan senyawa flavonoid dalam ekstrak etanol daun kersen memiliki aktivitas antibakteri terhadap Bacillus cereus, sedangkan senyawa tanin dalam ekstrak etanol daun kersen memiliki aktivitas antibakteri terhadap Shigella sonnei.  
Co-Authors AA Sudharmawan, AA Advistasari, Yustisia Dian Ahsaninnisa, Azizah Amanda, Pramaisshela Rizvya Andi Suhendi Azis Saifudin Benny Permana Broto Santoso Elisa, Novi Fahmi, Muhammad Zaini Fauzi Ahmad Muda Hidayah, Ariesta Adriena Putri Jaka Seprianto Lepangkari Kholifatul Hakimah, Wafiq Lepangkari, Jaka Seprianto Mufidah Maulina, Fariha Muhtadi Munawwarah Munawwarah Nindyasari, Asyifa Palupi, Ajeng Sekar Prasetyawati, Sandra Dewi Rachmawati, Fiony Diva Ramadhan, Muhammad Reza Riyanto, R Slamet Ibrahim Susantiningtyastuti, Aldila Wathony, Al Zafarani Azzuhra, Alifia