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All Journal Jurnal Biologi Tropis
Sakti, Hari Saktiningsih
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Relationship Between Compliance with Oral Hypoglycemic Drugs and Hs-CRP Levels in Type 2 Diabetes Mellitus Intan Nur Ramadhani; Sakti, Hari Saktiningsih
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9201

Abstract

Type 2 diabetes mellitus is a chronic condition with hyperglycemia due to insulin resistance and impaired insulin secretion, where oral medication non-compliance can worse glycemic control and trigger inflammation characterized by elevated hs-CRP levels. This research aims to examine the relationship between compliance with oral hypoglycemic drugs and hs-CRP levels in patients with diabetes mellitus. This study used a cross-sectional design with purposive sampling of 20 patients with type 2 diabetes mellitus at Puskesmas Mojolaban. Compliance was assessed by MARS-10 and hs-CRP levels were measured by immunoturbidimetry, then analyzed by descriptive statistics and correlation with Fisher’s Exact Test. The results showed that 95% of respondents who adhered to their medication had normal hs-CRP levels (<0.85 mg/L), while 5% of non-adherent respondents had abnormal hs-CRP levels (>0,85 mg/L). The Fisher’s Exact Test result in a p-value = 0.050, indicating a significant relationship between compliance with oral hypoglycemic drugs and hs-CRP levels. Compliance to oral medication in patients with type 2 diabetes mellitus may be an effective strategy to suppress systemic inflammation (hs-CRP) and prevent macrovascular compliactions.
Differences in Bacterial Types in Controlled and Uncontrolled Type II Diabetes Mellitus with Urinary Tract Infections Sakti, Hari Saktiningsih; Vector Stephen Dewangga; Sulasmi, Sulasmi
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8093

Abstract

Diabetes Mellitus (DM) is a group of metabolic disorders caused by various environmental, genetic and lifestyle factors as a result of a decrease in insulin secretion. An increase in the incidence of DM will certainly be followed by an increase in the possibility of chronic complications of DM. High glucose concentrations in urine are a good medium for the growth of pathogenic microorganisms, as a result, DM patients often experience urinary tract infections (UTI). The aim of this research is to find out the description of the identification of bacteria that cause urinary tract infections in controlled and uncontrolled type II diabetes mellitus. This research method uses an observational analytical research type with a cross-sectional approach. Data were analyzed descriptively to determine the identification of bacteria in controlled and uncontrolled DM.  The results of the research showed diabetes type 2 was uncontrolled with different types of bacteria, namely: Streptococcus sp (8.3%), Staphylococcus epidemidis (16.75), Salmonella paratyphi A (8.3%), Serratia marcescens (8.3% ), Pseudomonas aeruginosa (8.3%), Escherichia coli (16.67%), Enterococcus faecalis (8.3%), while controlled DM type 2 was found Staphylococcus aureus (8.3%), Escherichia coli (16.67%), Klebsiella pneumoniae (8.3%), Staphylococcus epidermidis (8.3%).
Co-Authors Intan Nur Ramadhani Sulasmi Sulasmi Vector Stephen Dewangga