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All Journal JURNAL FARMASIMED (JFM) Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Tio Widia Astuti Marpaung
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Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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KONSENTRASI HAMBAT MINIMUM (KHM) KADAR EKSTRAK ETANOL BATANG BAJAKAH TAMPALA (Spatholobus littoralis Hassk) TERHADAP BAKTERI ESCHERICHIA COLI MELALUI METODE SUMURAN Mochammad Maulidie Alfiannor Saputera; Tio Widia Astuti Marpaung; Noverda Ayuchecaria
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i2.267

Abstract

Empirically, one of the plants that are widely used by the Dayak tribe as a medicine is the bajakah tampala (Spatholobus littoralis Hassk.) This plant is claimed to be able to treat several diseases such as abdominal pain, diarrhea and dysentery. But until now studies on the antibacterial activity of bajakah tampala have never been done. This study studied the antibacterial activity of bajakah ethanol extract against the growth of Escherichia coli bacteria and minimum inhibitory value (MIC). This type of research is experimental research. The stem bajakah Tampala looks like it wastaken from the inland forest in Garung Village, Jabiren District, Pulang Pisau Regency, Central Kalimantan. The sample of this study was 70% ethanol extract of bajakah tampala stems obtained by maceration. Extract payment of antibacterial activity using a concentration of 3.12%; 6.25%; 12.5%; 25% and 50%. The positive control used is ampicillin 0.01 mg/ml and negative control using distilled water. Tests are carried out by the well method. The tested data were analyzed statistically by the One-Way ANOVA test method. The results of the study showed that the ethanol extract bajakah tampala could inhibit the growth of E. coli bacteria. The biggest inhibition of E. coli bacteria at a concentration of 50% with an average inhibition diameter of 20.32 mm. included in the category of very strong. The minimum inhibitory concentration of extract batang bajakah tampala is 6.25%
Formulation of Emollient Preparation from Rose Essential Oil (Rosa Damascena) Combined with Vanilla Essential Oil (Vanilla Planifolia)in Increasing Body Weight in Baby Rats (Rattus Norvegicus) arsyad, regina; Kintoko; Wahyu Widyaningsih; Tio Widia Astuti Marpaung
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/80n03c83

Abstract

Rose and vanilla essential oils have potential as natural active ingredients in emollient formulations due to their moisturizing and aromatherapeutic relaxation effects. This study aimed to formulate an aromatherapy emollient with four variations in the composition of rose and vanilla essential oils: F1 (0.1 mL:0.4 mL), F2 (0.2 mL:0.3 mL), F3 (0.3 mL:0.2 mL), and F4 (0.4 mL:0.1 mL). Each formula contained a total of 0.5 mL essential oil dissolved in 100 mL sunflower seed oil as the base. Organoleptic evaluation showed that all formulas had a yellowish-white color and liquid texture. The resulting aromas differed among formulas: F1 produced a woody scent, F2 and F3 had an oriental woody fragrance, while F4 exhibited a dominant rose aroma. The pH values ranged from 5.12 to 6.00, which is within the normal skin range. Viscosity values were between 4.92–5.30 cPs, specific gravity ranged from 1.0181–1.0682, and refractive indices were 1.470–1.471, indicating good physical stability. Hedonic testing revealed that Formula F2 was the most preferred by panelists in terms of aroma, texture, and after-feel on the skin. Skin irritation tests on rabbits showed no negative reactions, confirming the formulation’s safety for topical use. Biological activity tests on infant mice demonstrated significant increases in body weight and length compared to the control group. Based on overall results, Formula F2 (0.2 mL rose oil and 0.3 mL vanilla oil) was determined to be the best formulation, offering a balanced aroma, good physical stability, and optimal emollient and relaxation effects.
Co-Authors arsyad, regina Ayuchecaria, Noverda Kintoko Mochammad Maulidie Alfiannor Saputera Wahyu Widyaningsih