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All Journal Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Abdimas Indonesia Parapemikir Jurnal Ilmiah Farmasi An-Nas
Rahayu, Feri Kanti
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Religion Humanities Chemistry Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Physics Public Health Social Sciences Other

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FORMULASI SERUM NANOPARTIKEL EKSTRAK ETANOL KULIT BUAH KAKAO (Theobroma cacao L.) SEBAGAI ANTIOKSIDAN Rahayu, Feri Kanti
Parapemikir : Jurnal Ilmiah Farmasi Vol 14, No 1 (2025): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v14i1.7657

Abstract

Antioxidants are compounds that are able to stop oxidation reactions so that they can inhibit cell damage in the body. Cocoa pods (Theobroma cacao L.) contain polyphenols and flavonoids that function as free radical antidotes. This study aims to determine whether ethanol extract of cacao fruit peel (Theobroma cacao L.) can be formulated as a nanoparticle serum preparation and has antioxidant activity. This research was conducted at the Pharmacognosy, Instrument, and Pharmaceutical Technology Laboratory of STIKes Ibnu Sina Ajibarang. This type of research is descriptive experimental, namely characterisation of ethanol extract of cacao fruit skin with UV-Vis spectrophotometry, preparation of serum nanoparticles; physical evaluation through organoleptic test, homogeneity, pH, viscosity and cycling test and antioxidant activity test with DPPH (1,1-diphenyl-2picrylhydrazyl) method. The results of nanoparticle characterisation obtained a maximum wavelength of 430 nm with an absorbance of 0.353 at a concentration of 5 ppm showed a particle size of 50-60 nm. The results of the physical evaluation of the preparation showed that all formulations F0, FI, FII, and FIII met the requirements of the physical properties test and stability test, so it can be stated that cocoa fruit peel extract can be formulated as a nanoparticle serum preparation. The antioxidant activity test results of F0, FI, FII, and FIII were 5.12 ppm; 4.62 ppm; 4.28 ppm; 3.16 ppm, respectively. So it can be concluded that the most effective nanoparticle serum preparation is FIII with 3% extract concentration.
MOLEKULER DOCKING DAN ANALISIS ADMET SENYAWA ANREDERA CORDIFOLIA TERHADAP DPP-4: OBAT DIABETES Rahayu, Feri Kanti
Parapemikir : Jurnal Ilmiah Farmasi Vol 14, No 2 (2025): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v14i2.7596

Abstract

Diabetes is a degenerative disease characterized by hyperglycemia. Treatment of type 2 DM usually uses synthetic drugs that have side effects such as sulfonyl urea, biguanine, alpha-glycosidase drugs. Dipeptidyl Peptidase 4 (DPP4) enzyme inhibitor drugs have not been widely studied and have potential for hypoglycemia. This research aims to examine compound isolates from the binahong plant in inhibiting the DPP4 enzyme. The in silico method via molecular docking is the most relevant method in efforts to discover new drugs. Molecular docking is carried out through several stages including modeling and optimization of compound structures, preparation of target proteins and ligands, validation of docking, docking processes, and visualization of interactions and ADMET analysis. The research results show that of the 11 binahong plant compounds there are 3 compounds that have antidiabetic potential, namely 2,3-dihydroxypropyl palmitate, Squale and Linoleic acid, methyl ester with bond energy values respectively -104.1; -101.2; and 90.9 kcal/mol. ADMET analysis of 11 binahong plant compounds shows that the majority of compounds are absorbed through the gastrointestinal tract, distributed and metabolized with the help of the CYP1A2 enzyme and all compounds are not carcinogenic and not mutagenic. Based on the results of this research, it can be concluded that the compounds, namely 2,3-dihydroxypropyl palmitate, Squale and Linoleic acid, methyl ester can inhibit the DPP-4 enzyme and are not toxic so they have the potential to be antidiabetic.
STUDI SOSIOLINGUISTIK ALIH KODE DAN CAMPUR KODE BAHASA PAKSEL (NGAPAK JAKSEL) DALAMVIDEO TIKTOKRAFLY Rahayu, Feri Kanti; Festiyanti, Wilda Putri
An-Nas Vol. 8 No. 2 (2024): AN-NAS: Jurnal Humaniora
Publisher : Fakultas Syariah dan Adab Universitas Nahdlatul Ulama Sunan Giri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32665/annas.v8i2.3258

Abstract

“Language is a form of communication to convey information, thoughts, feelings, and goals or intentions to other people. In the era of globalization, the use of more than one language is often experienced by someone who is called a "bilingual" or "multilingual" person. The ability to use more than one language in communication is often encountered in everyday life. One example is Rafly Paksel's TikTok video, where Rafly Paksel always uses more than one language when communicating or speaking, namely combining or inserting Indonesian with Javanese. So from this phenomenon the researcher aims to identify the types of code switching and language code mixing that Rafly Paksel uses in his TikTok videos. This research is a qualitative descriptive research with data collection methods based on primary data sources and secondary data. "Based on data analysis, the phenomenon of code switching and code mixing that Raply Paksel uses when speaking in his TikTok videos is inter sentential type code switching, and the code mixing that is often used by Raply Paksel is intra sentential mixing."
Edukasi Interaksi Obat dan Jamu di Desa Cibangkong Kecamatan Pekuncen Rinia Dewi, Iva; Nur cahyani, Arinda; Rahayu, Feri Kanti; Cahyani, Cici
jurnal ABDIMAS Indonesia Vol. 3 No. 4 (2025): Desember : Jurnal ABDIMAS Indonesia
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jai.v3i4.3412

Abstract

The community in Cibangkong Village, Pekuncen District, Banyumas Regency, still widely uses jamu (traditional herbal medicine) as part of their daily healthcare practices, often in combination with modern medical drugs. Limited understanding of the potential interactions between herbal and pharmaceutical medicines may pose health risks. This community service activity aimed to improve public knowledge and awareness regarding the dangers of drug–herb interactions through educational and interactive approaches. The implementation methods included health education sessions and group discussions. Participants of the activity were members of Muslimat NU 1 Pekuncen. The results showed a 60% improvement in community understanding, based on simple pre-test and post-test evaluations. The community also became more cautious and motivated to consult healthcare professionals before consuming jamu together with prescription medicines. This activity successfully increased public awareness about the safe and responsible use of both modern and traditional medicines.
Computational Analysis of Biflavonoid Derivatives through Molecular Docking on ALK Kinase Receptor as Potential Inhibitors of A549 Cell Proliferation Rahayu, Feri Kanti; Cahyani, Arinda Nur; Prayogi, Syaiful; Anggraeni, Dossy Susan; Zahra, Putri Aulia; Ernanda, Azzahra Rhisma; Falupi, Indah Fajar; Rahma, Dila
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.678

Abstract

Lung cancer remains one of the leading causes of cancer-related mortality worldwide. In Indonesia, it ranks third after cervical and breast cancers, with non-small-cell lung carcinoma (NSCLC) being the most prevalent type, accounting for 85–88% of cases. Anaplastic lymphoma kinase (ALK) is a key molecular target in NSCLC, contributing significantly to carcinogenesis. However, resistance to current ALK-targeted therapies poses a major challenge. To address this, new drug discovery efforts are urgently needed. While drug development is typically time-consuming and costly, Computer-Aided Drug Design (CADD) offers an efficient strategy at the early stages. Biflavonoid derivatives have shown anticancer potential but are limited by poor solubility and low activity, warranting further optimization. This study explores structural modifications of biflavonoid derivatives to identify potential ALK inhibitors. The results indicate that the modified compounds (Compounds A and B) demonstrated binding affinities comparable to the reference drug, Entrectinib, suggesting their promise as novel anticancer candidates.
Co-Authors Anggraeni, Dossy Susan Arinda Nur Cahyani Cahyani, Cici Ernanda, Azzahra Rhisma Falupi, Indah Fajar Festiyanti, Wilda Putri Nur cahyani, Arinda Prayogi, Syaiful Rahma, Dila Rinia Dewi, Iva Zahra, Putri Aulia