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HUBUNGAN BEBAN KERJA MENTAL DENGAN DEPRESI DAN CEMAS PADA PERAWAT ICU-NICU-PICU DI RS MITRA SEJATI: ANTIBACTERIAL EFFECTIVENESS OF TURMERIC RHIZOME ETHANOL EXTRACT (CURCUMA DOMESTICA VAL) AGAINST VIBRIO CHOLERAE GROWTH IN VITRO Sitepu, Arneil; Siddiq, Muhraza; Siagian, Nurul Aini
Jurnal Kedokteran STM (Sains dan Teknologi Medik) Vol. 8 No. 1 (2025): Januari 2025
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/stm.v8i1.819

Abstract

Vibrio cholerae is a Gram-negative, anaerobic bacterium. Cholera is an intestinal infection caused by Vibrio cholerae or contact with a cholera carrier. Turmeric rhizome (Curcuma domestica Val) extract is known to have antibacterial properties. Active compounds such as flavonoids, saponins, alkaloids, and tannins in turmeric rhizomes have been shown to inhibit the growth of Vibrio cholerae. This study aimed to evaluate the antibacterial effectiveness of turmeric rhizome extract (Curcuma domestica Val) against the growth of Vibrio cholerae in vitro. The research used a descriptive approach with experimental methods, conducted at the Microbiology and Organic Chemistry Laboratory, University of Sumatera Utara (USU). Extraction was performed using the maceration method. The study employed four different concentrations of turmeric rhizome extract: 25%, 50%, 75%, and 100%. Data collection involved treating Vibrio cholerae cultures with the extracts and measuring the diameter of the inhibition zones using a caliper. Data analysis was conducted using ANOVA and a Post Hoc Bonferroni test. Results showed that the 100% concentration of turmeric rhizome extract was the most effective in inhibiting the growth of Vibrio cholerae, with a p-value of 0.000, an average inhibition zone diameter of 22.2 ± 0.49 mm, and a categorization of "susceptible" response. AbstrakPenelitian ini mengeksplorasi hubungan antara beban kerja mental dengan tingkat depresi dan kecemasan pada perawat di unit ICU dan NICU-PICU di RS Mitra Sejati. Metode penelitian menggunakan desain deskriptif kuantitatif dengan pendekatan analitik. Sampel terdiri dari 44 perawat yang diambil secara total sampling. Instrumen meliputi kuesioner untuk mengukur beban kerja mental, tingkat depresi, dan kecemasan. Analisis statistik menunjukkan bahwa sebagian besar perawat di ICU dan NICU-PICU memiliki beban kerja mental tinggi hingga sangat tinggi, dengan tingkat depresi dan kecemasan berat. Namun, uji korelasi spearman mengungkapkan bahwa beban kerja mental tidak memiliki hubungan signifikan dengan tingkat depresi (ρ=0,796) atau kecemasan (ρ=0,797). Hasil ini mengindikasikan adanya faktor lain, seperti dukungan sosial dan strategi coping, yang dapat memoderasi dampak beban kerja mental. Penelitian ini merekomendasikan pendekatan holistik untuk mengelola beban kerja, termasuk penguatan dukungan sosial dan program pengurangan stres untuk meningkatkan kesejahteraan perawat.
Positive and Negative Syndrome Scale and High-Density Lipoprotein Cholesterol Levels Sitepu, Arneil
Indonesian Journal of Global Health Research Vol 6 No S6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS6.5255

Abstract

Schizophrenia is a chronic psychopathological disorder characterized by distortions in cognition, emotion, perception, and behavior. In addition, patients with schizophrenia have a higher risk of cardiometabolic problems, such as obesity, type 2 diabetes, hypertension, hyperglycemia, and dyslipidemia, compared to the general population. Objective to determine the correlation between the total score of the Positive and Negative Syndrome Scale (PANSS) and High-Density Lipopretein-Cholesterol (HDL-C) levels in men with chronic schizophrenia. The sampling method is non-probability sampling with consecutive sampling type with a total of 77 people. Samples that meet the inclusion criteria and are willing to participate in further research, will be interviewed with the Mini International Neuropsychiatric Interview (MINI) ICD-10 (A1) version where the diagnosis is made using diagnostic guidelines based on PPDGJ-III. If they meet the criteria, they are asked to fill out the PANSS questionnaire. This analysis uses the Pearson Correlation. The results with the correlation test between HDL-C level and total PANSS score were tested using the Pearson test. From the results above, it was obtained p-value<0.001 which indicates that there is a very significant correlation between PANSS score and HDL-C level. The Pearson correlation value of r=-0.68 suggests a negative correlation with strong correlation strength, this indicates that the lower the HDL-C level, the higher the total PANSS score. We found a negative correlation with a strong correlation, this suggests that the lower the HDL-C level, the higher the total PANSS score.