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Fariz Nurwidya
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Cryptogenic Organizing Pneumonia (COP) Fariz Nurwidya; Aprilia Katarina
MEDICINUS Vol. 38 No. 2 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/4yy1sr23

Abstract

Organizing pneumonia (OP) merupakan respons cedera paru nonspesifik dengan berbagai pola pencitraan yang didapatkan melalui pemeriksaan high-resolution computed tomography (HRCT) toraks dan secara histopatologis ditemukan sel radang serta matriks jaringan ikat di saluran pernapasan bagian distal. Organizing pneumonia (OP) dengan etiologi yang tidak diketahui disebut sebagai cryptogenic organizing pneumonia (COP) dan diklasifikasikan menjadi penyakit paru interstisial akut atau subakut. Kasus COP terjadi akibat cedera alveolar dan terdapat obstruksi jaringan granulasi di lumen alveolar serta bronkiolus. Gejala klinis COP berupa demam, batuk, lemas, dan sesak napas dengan tingkat keparahan ringan hingga berat. Biopsi jaringan merupakan pemeriksaan penunjang yang penting untuk diagnosis COP. Sejauh ini, belum ada penelitian yang membandingkan terapi atau durasi pengobatan dalam kasus COP. Pasien dengan gejala progresif serta gambaran radiologis difus diberikan terapi corticosteroid oral dengan hasil yang relatif baik. Walaupun demikian, pasien COP dapat mengalami kekambuhan setelah terapi tersebut.
Respiratory Syncytial Virus (RSV): Virologi, Patogenesis, Respon Imun, dan Vaksin Pada Dewasa Resti H. Lestari; Fariz Nurwidya; Anis Karuniawati
MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/n0vpzd50

Abstract

Respiratory syncytial virus (RSV) is classified within the Pneumoviridae family, genus Orthopneumovirus. RSV is a single-stranded, negative-sense RNA virus and has two genotypes, A and B. It is primarily associated with lower respiratory tract infections, including bronchiolitis and bronchopneumonia, and is a common cause of hospitalization in infants, elderly individuals, and immunocompromised patients. RSV also has the potential to become systemic infection. Symptoms of RSV infection, such as fever, cough, sore throat, and runny nose, are usually mild in adults. However, in some cases, especially for specific high-risk individuals, the infection can become severe enough to require hospitalization, and complications may lead to death. Understanding the pathogenesis and immune response to RSV are crucial for recognizing the virus’s effects and potential risks. This literature review covers the virology, pathogenesis, immune response, and recent advancements in RSV vaccine development in adult populations. Comprehensive knowledge of RSV is essential for developing effective prevention and treatment strategies.
Co-Authors Anis Karuniawati Aprilia Katarina Resti H. Lestari