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All Journal SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Sains Medisina
Ifmaily
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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THE EFFECT OF CORN SILK ETHANOL EXTRACT (Zea mays L.) ON THE BLOOD GLUCOSE LEVELS AND HISTOPATHOLOGY OF PANCREAS IN ALLOXAN-INDUCED MICE Nessa, Nessa; Ifmaily; Wahyu Putri, Sri
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 4 No. 1 (2025): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v4i1.110

Abstract

Diabetes Mellitus is a metabolic disorder that occurs because pancreatic cells produce insulin in small amounts. The purpose of this study was to determine the effect of giving corn silk (Stigma maydis) to alloxan-induced mice to determine the effective dose of corn silk extract that can reduce blood glucose levels in hyperglycemic mice and histopathological features. This research is an experimental type that uses 24 male white mice as experimental animals, divided into 6 groups and each group consists of 4 mice consisting of negative control, positive control, dose variation 100mg/kgBW, 200mg/kgBW, 400mg/kgBW and the comparison group (Glibenclamide 0.65mg/kgBW). The inducer used was alloxan 150 mg/kg bw. Alloxan induction was carried out for 3 days and then the test preparation was given until the 17th day. Mice's blood was taken through the lateral tail vein to see blood sugar levels. Based on the results of measuring the blood glucose levels of mice on day 17, the average value of blood glucose levels was negative control (86.25 mg/dl), positive control (223 mg/dl), dose 100 mg/kgbb (109.75 mg /dl), dose 200 mg/kgbb (103.5 mg/dl), dose 400 mg/kgbb (92.5 mg/dl), glibenclamide 0.65mg/kgbb (95 mg/dl). Based on the results of statistical data analysis, two-way ANOVA showed significantly different results (p<0.05). The results of reducing blood glucose levels that were closest to the negative control were shown by corn silk extract at a dose of 400 mg/kgbb, while histopathological observations of the pancreas after administration of ethanol extract of corn silk at a dose of 200 mg/kgbb showed the best healing in the islets of Langerhans.
Uji Efektivitas Salep Ekstrak Kulit Buah Jeruk Manis (Citrus sinensis (L.)) Terhadap Penyembuhan Luka Infeksi Irwandi; Ifmaily; Dara
Sains Medisina Vol 4 No 2 (2025): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v4i2.892

Abstract

Jeruk manis (Citrus sinensis (L.)) merupakan tanaman yang mengandung senyawa metabolit sekunder yaitu, flavonoid, alkaloid, tanin, dan saponin yang memiliki aktivitas antibakteri sehingga berpotensi membantu proses penyembuhan luka infeksi. Tujuan dilakukan penelitian ini untuk melihat efektivitas salep ekstrak kulit buah jeruk manis (Citrus sinensis (L.)) terhadap penyembuhan luka infeksi yang disebabkan oleh bakteri Staphylococcus aureus. Penelitian ini dilakukan selama 14 hari menggunakan 25 hewan uji tikus dibagi menjadi 5 ekor tikus pada setiap kelompok perlakuan yaitu kontrol, pembanding, F1(5%), F2(10%), F3 (20%). Parameter yang diamati pada penelitian ini adalah persen luas penyembuhan luka dan waktu epitelisasi. Data dianalisis menggunakan uji statistik ANOVA satu arah dan dua arah dilanjutkan uji Duncan. Hasil penelitian pada persentase penyembuhan luka berturut-turut hari ke-3, ke-7, ke-14, kontrol: 25,01%; 78,35%; 86,18%; pembanding: 34,76%; 82,21%; 94,43%; F1(5%): 45,56%; 73,42%; 87,34%; F2 (10%): 37,37%; 88,90%; 92,51%; F3 (20%):  43,59%; 85,87%; 93,52%. Persen penyembuhan luka yang paling tinggi terdapat pada F3 (20%) dibandingkan kontrol. Hasil penelitian pada waktu epitelisasi secara berturut-turut, kontrol: 8,6; pembanding: 6,6; F1 (5%): 7,2; F2 (10%): 8, dan F3 (20%): 8,4. Waktu epitelisasi yang paling baik terdapat pada F1 (5%) dibandingkan kontrol. Jadi dapat disimpulkan salep ekstrak kulit buah jeruk manis memiliki pengaruh dalam penyembuhan luka infeksi yang disebabkan oleh bakteri Staphylococcus aureus.
Co-Authors Dara Irwandi Nessa Nessa Wahyu Putri, Sri