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All Journal Jurnal Penelitian Kesehatan Suara Forikes Jurnal Ilmiah Farmako Bahari Jurnal Pijar MIPA Journal of Pharmaceutical and Sciences.
Shella, Tasya Permata
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Systematic Review: Optimalisasi Stabilitas Retinol Pada Sediaan Kosmetika Shella, Tasya Permata; Ratnasari, Devi; Cahyani, Theresia Natalie; Adzkia, Muhammad Adit; Valentin, Diva; Az-Zahraa, Ailla
Jurnal Ilmiah Farmako Bahari Vol 16 No 1 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v16i1.41811

Abstract

Retinol adalah bentuk aktif dan turunan generasi pertama dari vitamin A yang yang memiliki banyak manfaat untuk perawatan kulit, seperti memperbaiki tekstur kulit, merangsang pembentukan kolagen, dan mengatasi masalah penuaan serta jerawat yang membuat retinol banyak dibuat dalam sediaan kosmetika. Namun, stabilitas retinol dalam sediaan kosmetik memiliki banyak tantangan karena rentan mengalami degradasi akibat paparan faktor eksternal yang dapat memicu efek toksisitas retinol. Sehingga, review ini bertujuan untuk mengidentifikasi faktor-faktor yang dapat meningkatkan stabilitas retinol dalam sediaan kosmetik. Melalui kajian literatur dari 15 jurnal internasional dalam kurun waktu 10 tahun terakhir, ditemukan bahwa penambahan berbagai eksipien dan zat aktif lain dalam formulasi, penggunaan berbagai metode pembuatan seperti emulsi, enkapsulasi mikropartikel dan nanopartikel dengan beragam matriks, serta pemilihan kemasan yang sesuai dapat secara signifikan meningkatkan stabilitas retinol.
Antioxidant Activity of Gel Formulations Containing Various Plant Leaf Extracts: A Review Valentin, Diva; Ratnasari, Devi; Az-zahraa, Ailla; Cahyani, Theresia Natalie; Shella, Tasya Permata; Adzkia, Muhammad Adit
Jurnal Pijar Mipa Vol. 20 No. 1 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i1.8288

Abstract

Antioxidants protect the skin from the adverse effects of free radicals, which can potentially trigger premature aging and even skin cancer. Free radicals, with unpaired electrons, are highly reactive and can damage cellular structures. However, the high risk of side effects from synthetic antioxidants, such as skin cancer, has increased interest in natural sources. In cosmetic formulations, gel preparations are highly favored because they can optimally and stably deliver active ingredients to the skin. This study employed a literature review method by examining and collecting articles from relevant scientific journals published over the past 10 years (2014–2024), with 13 articles as primary references. The analysis found that several extracts, such as leilem leaf, pandan, and green tea, exhibited strong antioxidant potential, as indicated by low IC50 values, making them ideal as active ingredients in gel formulations. In addition to the type of plant leaves, the effectiveness of these antioxidants is influenced by the extract concentration used, solvent selection during extraction, and the processing techniques employed in formulation.
Artikel Review: Pengaruh Bahan Polimer Terhadap Uji Disolusi Tablet Salut Enterik Cahyani, Theresia Natalie; Ratnasari, Devi; Shella, Tasya Permata; Az-zahraa, Ailla; Valentine, Diva; Adzkia, Muhammad Adit
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 16, No 1 (2025): Januari-Maret 2025
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v16i1.5587

Abstract

Tablet salut enterik memiliki peran penting dalam meningkatkan bioavailabilitas obat dengan melindungi zat aktif dari lingkungan asam lambung dan memungkinkan pelepasannya dalam usus, di mana penyerapan optimal dapat terjadi. Salah satu faktor kunci yang memengaruhi keberhasilan tablet salut enterik adalah pemilihan polimer yang digunakan dalam lapisan salut. Artikel review ini mengkaji bagaimana karakteristik dan konsentrasi berbagai polimer memengaruhi disolusi dan bioavailabilitas obat pada tablet salut enterik. Metode yang digunakan pada pengumpulan data dalam review ini adalah studi literatur review, dengan mencari dan mengumpulkan artikel dari jurnal ilmiah yang telah diterbitkan sebelumnya dengan kata kunci yang sesuai. Polimer yang umum digunakan, seperti Eudragit, Kollicoat MAE 30D, cellulose acetate phthalate, HPMCP, chitosan succinate, dan ethyl cellulose. Masing-masing polimer memiliki karakteristik unik yang memengaruhi profil disolusi di lingkungan asam dan basa. Konsentrasi dan jenis polimer ini menentukan waktu pelepasan serta kestabilan zat aktif, yang pada akhirnya berdampak pada efektivitas terapeutik obat.Kata kunci: : tablet salut enterik, polimer, disolusi
Interaksi Obat-Herbal dengan Agen Hormon dalam Terapi Kanker: Tinjauan Mekanisme dan Implikasi Klinis Zulqifli, Iqbal; Hikmah, Nurul; Shella, Tasya Permata; Azizah, Nabilla Faoziyyah; Apriani, Risa Dwi; Putri, Mukarromah Dita; Hilmi , Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1073

Abstract

Hormone therapy is the cornerstone of treatment for hormone-dependent cancers, such as breast and prostate cancer. On the other hand, the high rate of herbal medicine use as complementary treatment in cancer patients has the potential to cause herbal drug interactions (HDIs), which can affect the efficacy and safety of the primary therapy. This study aims to identify and categorize drug-herbal interactions (DHIs) in cancer hormone therapy based on pharmacokinetic mechanisms (including CYP450 enzyme and drug transporter modulation) and pharmacodynamic mechanisms (including hormone receptor and signaling pathway modulation), as well as to conclude their clinical implications. A systematic review was conducted following the PRISMA-ScR guidelines. A literature search was performed in the PubMed, Scopus, ScienceDirect, Frontiers, and Google Scholar databases for relevant in silico, in vitro, and in vivo studies published between 2015 and 2025. Analysis showed that HDI can be categorized into two main groups. First, pharmacokinetic interactions that occur through the modulation of cytochrome P450 (CYP) enzymes and drug transporters, such as the reduction in the bioavailability of tamoxifen by Hedyotis diffusa. Second, pharmacodynamic interactions at hormone receptors, such as the synergistic effect between Boswellia serrata and enzalutamide. The nature of interactions varies greatly, from antagonistic to synergistic, depending on the specific herbal-drug pair. These findings emphasize the importance of clinical vigilance, such as open communication with patients, dose adjustments, therapeutic monitoring, and interprofessional collaboration. These measures are necessary to reduce the risk of HDI and improve the efficacy of cancer therapy.
Co-Authors Adzkia, Muhammad Adit Adzkia, Muhammad Adit Apriani, Risa Dwi Az-zahraa, Ailla Az-Zahraa, Ailla Azizah, Nabilla Faoziyyah Cahyani, Theresia Natalie Cahyani, Theresia Natalie Hilmi , Indah Laily Nurul Hikmah Putri, Mukarromah Dita Ratnasari, Devi Ratnasari, Devi Valentin, Diva Valentine, Diva Zulqifli, Iqbal