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All Journal Jurnal Ilmiah Farmako Bahari Jurnal Pijar MIPA Journal of Pharmaceutical and Sciences.
Adzkia, Muhammad Adit
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Systematic Review: Optimalisasi Stabilitas Retinol Pada Sediaan Kosmetika Shella, Tasya Permata; Ratnasari, Devi; Cahyani, Theresia Natalie; Adzkia, Muhammad Adit; Valentin, Diva; Az-Zahraa, Ailla
Jurnal Ilmiah Farmako Bahari Vol 16 No 1 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v16i1.41811

Abstract

Retinol adalah bentuk aktif dan turunan generasi pertama dari vitamin A yang yang memiliki banyak manfaat untuk perawatan kulit, seperti memperbaiki tekstur kulit, merangsang pembentukan kolagen, dan mengatasi masalah penuaan serta jerawat yang membuat retinol banyak dibuat dalam sediaan kosmetika. Namun, stabilitas retinol dalam sediaan kosmetik memiliki banyak tantangan karena rentan mengalami degradasi akibat paparan faktor eksternal yang dapat memicu efek toksisitas retinol. Sehingga, review ini bertujuan untuk mengidentifikasi faktor-faktor yang dapat meningkatkan stabilitas retinol dalam sediaan kosmetik. Melalui kajian literatur dari 15 jurnal internasional dalam kurun waktu 10 tahun terakhir, ditemukan bahwa penambahan berbagai eksipien dan zat aktif lain dalam formulasi, penggunaan berbagai metode pembuatan seperti emulsi, enkapsulasi mikropartikel dan nanopartikel dengan beragam matriks, serta pemilihan kemasan yang sesuai dapat secara signifikan meningkatkan stabilitas retinol.
Antioxidant Activity of Gel Formulations Containing Various Plant Leaf Extracts: A Review Valentin, Diva; Ratnasari, Devi; Az-zahraa, Ailla; Cahyani, Theresia Natalie; Shella, Tasya Permata; Adzkia, Muhammad Adit
Jurnal Pijar Mipa Vol. 20 No. 1 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i1.8288

Abstract

Antioxidants protect the skin from the adverse effects of free radicals, which can potentially trigger premature aging and even skin cancer. Free radicals, with unpaired electrons, are highly reactive and can damage cellular structures. However, the high risk of side effects from synthetic antioxidants, such as skin cancer, has increased interest in natural sources. In cosmetic formulations, gel preparations are highly favored because they can optimally and stably deliver active ingredients to the skin. This study employed a literature review method by examining and collecting articles from relevant scientific journals published over the past 10 years (2014–2024), with 13 articles as primary references. The analysis found that several extracts, such as leilem leaf, pandan, and green tea, exhibited strong antioxidant potential, as indicated by low IC50 values, making them ideal as active ingredients in gel formulations. In addition to the type of plant leaves, the effectiveness of these antioxidants is influenced by the extract concentration used, solvent selection during extraction, and the processing techniques employed in formulation.
Interaksi Obat Pada Pasien Geriatri: Kajian Berbasis Evidence Tentang Kombinasi Antihipertensi dan Obat Non Steroidal Anti-Inflammatory Alya, Rahma; Khuriyah, Khuriyah; Ananda, Meisya Dwi; Putra, Hasan Etanov; Adzkia, Muhammad Adit; Putri, Mukarromah Dita; Hilmi, Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1182

Abstract

The number of elderly individuals continues to increase globally, accompanied by a high prevalence of chronic diseases, particularly hypertension and musculoskeletal disorders. This condition makes geriatric patients vulnerable to polypharmacy, which increases the risk of drug interactions, one of which is between antihypertensives and non-steroidal anti-inflammatory drugs (NSAIDs). Such interactions can potentially reduce therapy effectiveness, cause electrolyte disturbances, and lead to acute kidney injury (AKI). This study aims to comprehensively examine the interaction between antihypertensives and NSAIDs in geriatric patients and its impact on therapy safety. The method used is a literature review by selecting national and international articles published between 2015 and 2025, written in either Indonesian or English, specifically investigating interactions between antihypertensives (β-blockers, ACE inhibitors, ARBs, diuretics, and CCBs) and NSAIDs. The review results indicate that most interactions are pharmacodynamic, involving either antagonism or negative synergism. NSAIDs can reduce the effectiveness of antihypertensive therapy through mechanisms such as sodium retention, afferent arteriolar vasoconstriction, and decreased renal perfusion. In certain combinations, such as the triple whammy phenomenon (NSAIDs, diuretics, and RAAS inhibitors), the risk of AKI and hyperkalemia increases significantly. This risk is higher in geriatric patients with decreased kidney function, comorbidities, and concurrent use of multiple drugs. In conclusion, the interaction between antihypertensives and NSAIDs in the elderly population is an important clinical issue. Therefore, close monitoring of kidney function and electrolytes, using the lowest effective dose for the shortest possible duration, and patient education to avoid self-medication are necessary to ensure therapy safety.
Co-Authors Alya, Rahma Ananda, Meisya Dwi Az-Zahraa, Ailla Cahyani, Theresia Natalie Indah Laily Hilmi Khuriyah . Putra, Hasan Etanov Putri, Mukarromah Dita Ratnasari, Devi Shella, Tasya Permata Valentin, Diva