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All Journal Borneo Journal Of Pharmascientech Journal of Chemistry Sciences and Education
Pramiastuti , Oktariani
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Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Aktivitas Antioksidan Serbuk Biji Salak (Salaca Zalacca Gaertn. Voss) Menggunakan Metode Dpph (1,1 Diphenyl-2- Picrylhydrazil) Rejeki, Desi; Pramiastuti , Oktariani; Candra Wiguna, Julio
Journal of Chemistry Sciences and Education Vol 1 No 02 (2024): Journal of Chemistry Sciences and Education
Publisher : PT. Pubsains Nur Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69606/jcse.v1i02.162

Abstract

Salak seeds are a part of the snake fruit plant that is often ignored by the public and considered as waste. Based on several research results, snake fruit has good nutritional content for health, snake fruit contains iron, is high in carbohydrates, calcium, phosphorus and vitamin C. This research aims to determine the antioxidant content in snake fruit powder. The DPPH method was chosen because it is one of the methods for determining antioxidant activity that is the fastest, simplest, and has been widely used with various solvents such as methanol and ethanol. The solvent used in this research was methanol pro analysis, because it has very high purity properties.  The activity test results used the DPPH method and the IC50 value obtained for salak seed powder was 90.89 ppm, this result is classified as a strong antioxidant.
Uji Aktivitas Adaptogenik Ekstrak Etanol Buah Jambu Biji (Psidium guajava L.) pada Mencit Menggunakan Metode Swimming Endurance Test Pramiastuti , Oktariani; Muzaeni , Doni Wahyu; Istriningsih , Endang
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.662

Abstract

Adaptogenic activity is related to antioxidant activity that can neutralize the adverse effects of stress by reducing the formation of reactive oxygen species (ROS) in the early phase. Psidium guajava has been known to have antioxidant activity, one of which is the highest Vitamin C content in guava fruit among other fruits, strengthening the suspicion that this fruit has adaptogenic activity. This study was conducted with the aim of testing the adaptogenic activity produced from guava fruit using the swimming endurance test (SET) method. Guava fruit extract was produced from the maceration process using 96% ethanol solvent. The SET test was conducted to determine the immobile time in 5 groups of mice that were given orally for 7 consecutive days. CMC-Na 0.5% as a negative control was given to group I, amitriptyline 25 mg/Kg BW as a positive control was given to group II, and extracts with doses of 50, 150 and 250 mg/Kg BW were given to groups III, IV and V, respectively. The results showed adaptogenic activity if the immobilization time of the group given guava fruit ethanol extract was lower than the negative control group. At doses of 50, 150, and 250 mg/Kg BW, the test findings demonstrated that guava fruit ethanol extract was able to shorten the period that mice were immobilized in comparison to the negative control group, indicating that guava fruit ethanol extract has adaptogenic activity. This activity cannot be separated from the role of several groups of compounds, and a few of them are regarded as alkaloids, flavonoids, tannins, saponins, and vitamin C.
Co-Authors Candra Wiguna, Julio Istriningsih , Endang Muzaeni , Doni Wahyu Rejeki, Desi