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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Kesehatan dr. Soebandi
Dewi Fitriani Puspitasari
STIFAR Yayasan Pharmasi Semarang
Health Professions Medicine & Pharmacology Nursing Public Health

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Comparative Dissolution Study Between Resveratrol Nanocream Formula and Conventional Resveratrol Cream with Dimethylsulfoxide Addition Dewi Fitriani Puspitasari; Rahmawati Salsa Dinurrosifa
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.9660

Abstract

Resveratrol has potential activity as an antioxidant. Several studies have formulated resveratrol into topical preparations, but the low solubility of resveratrol causes low release of the active substance. Dimethylsulfoxide is a widely used ingredient in topical preparations, which can be used to increase the solubility of poorly soluble substances Nanocream is a nanoparticle-based topical drug delivery. The globule size is nanoscale, which can help improve drug solubility. The aim of the research was to conduct a comparative dissolution study between resveratrol nanocream formula and resveratrol conventional cream preparation with the addition of dimethylsulfoxide at various concentrations of 3%, 5% and 7%. The research method began with formulating resveratrol nanocream preparation. The preparation consisted of lipid components dispersed into a cream base. The lipids consisted of VCO, tween 80 and propylenglycol. Loading drug of resveratrol lipid was 300 mg, then tested for transimtance value and globule size. Conventional resveratrol cream formula was made into FI, FII and FIII, where each formula used different concentration of DMSO. Physical characteristics testing was conducted on nanocream and conventional resveratrol cream.Analysis of dissolution test results was observed among FI, FII and FIII in conventional cream formulas. The dissolution test results of these three formulas were also compared with the resveratrol nanocream preparation. Observation of dissolution results was assessed from the percentage of active substance released at minutes 5, 10, 15, 30, 45, 60.The dissolution test results showed that there was no significant difference in the percentage of active substance released between the conventional resveratrol cream preparation formulas, but there was a significant difference between the three conventional resveratrol cream preparation formulas and the resveratrol nanocream preparation. 
Formulation of Polyethylene Glycol Based Ibuprofen Nanosuppository Preparations and Assesment of Dissolution Dewi Fitriani Puspitasari; Yani Kresnawati
Jurnal Kesehatan dr. Soebandi Vol 12 No 2 (2024): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v12i2.743

Abstract

Ibuprofen is widely formulated in oral and rectal dosage forms. Ibuprofen in the rectal route shows c max and t max longer than syrup preparations, this is due to the low solubility of ibuprofen. Nanoparticles are one of the technologies that are widely used to increase the solubility of an active substance. Nanoscale particle size, can increase the solubility of ibuprofen and allow dose reduction. This study aims to formulate ibuprofen nanosuppository preparations, and test the percent dissolution of nanosuppositories compared to conventional suppositories. The ibuprofen nanosuppository formulation consists of ibuprofen lipid component and PEG mix component (PEG 4000: PEG 6000). The ibuprofen lipid component consisted of ibuprofen VCO oil, tween 80 and propylenglycol. This lipid component was then tested for physical characteristics, transmittance, particle size and zeta potential, then the lipid was added to the suppository base component. The responses observed were disintegration time, hardness, and non-intrinsic dissolution efficiency. The test results showed transmittance values of 91.98%, 92.99%, 93.26%. Particle size and potential zeta values of FI = 107, 5 nm, FII 102 nm and FIII 103 nm. The zeta potential were -16.19 mV, -12.44 and -13.25 mV in the lipid component. The test results of the disintegration time of F1, F2, F3 nanosuppositories were 12 minutes, 11 minutes and 10 minutes. The hardness of F1, F2, and F3 were 1.53 kg, 1.43 kg and 1.26 kg and the dissolution efficiency value was higher than conventional suppositories. Modification of ibuprofen nanosuppositories had a significant effect on the percent dissolution of ibuprofen.
Co-Authors Rahmawati Salsa Dinurrosifa Yani Kresnawati