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Antibacterial Activity Testing on APMS (p-Methoxy Cinnamic Acid) Against Escherichia coli Bacteria Ahmad Fuad Masduqi; Erwin Indriyanti; Rahmawati Salsa Dinurrosifa
JURNAL ILMIAH SAINS Volume 21 Nomor 2, Oktober 2021
Publisher : Sam Ratulangi University

This study aims to determine whether the compound APMS (p-methoxy cinnamic acid) has the antibacterial activity of Escherichia coli and to determine the effective concentration of the compound APMS (p-methoxy cinnamic acid) in inhibiting the growth of Escherichia coli bacteria. This research begins with the synthesis of APMS obtained through the knoevenagel condensation reaction with the sonochemical method. The synthesized compounds were tested organoleptically and their melting points were measured. The structure of the results was elucidated using FT-IR and GC-MS, then tested the antibacterial activity of APMS compounds against Escherichia coli. Data analysis with SPSS, 99% confidence level (p<0.01) and continued with ANOVA test. The compound synthesized by APMS is in the form of fine crystals with a glossy white color, has a characteristic odor, and produces a % yield of 92.71%. The level of p-methoxy cinnamic acid (APMS) produced from this study was 95% using the GC-MS Instrument. APMS compounds have antibacterial activity against Escherichia coli. The average inhibition zone formed at a concentration of 5%; 10%; and 15% respectively are 0.695 cm; 0.727 cm; and 0.855 cm The optimal concentration of this study was at a concentration of 15% which gave the greatest inhibitionKeywords: Antibacterial; Escherichia coli; p-Methoxy cinnamic acidUji Aktivitas Antibakteri Senyawa APMS (Asam p_Metoksi Sinamat) Terhadap Bakteri Escherichia coliÂ Â ABSTRAKPenelitian ini bertujuan untuk mengetahui apakah senyawa APMS (Asam p-metoksisinamat) memiliki aktivitas antibakteri Escherichia coli dan mengetahui konsentrasi efektif dari senyawa APMS (Asam p-metoksisinamat) dalam menghambat pertumbuhan bakteri Escherichia coli. Penelitian ini diawali dengan sintesis APMS ini didapatkan melalui reaksi kondensasi knoevenagel dengan metode sonokimia. Senyawa hasil sintesis diuji organoleptis dan diukur titik leburnya. Struktur hasil dielusidasi menggunakanÂ FT-IR dan GC-MS, kemudian uji aktivitas antibakteri senyawa APMS terhadap Escherichia coli. Analisis data dengan SPSS, tingkat kepercayaan 99% (p<0,01) dan dilanjutkan uji ANOVA. Senyawa hasil sintesis APMS berupa kristal halus berwarna putih mengkilap, memiliki bau khas, dan menghasilkan % yield sebesar 92,71%. Kadar Asam Para Metoksisinamat (APMS) yang dihasilkan dari penelitian ini sebesar 95% menggunakan Instrumen GC-MS. Senyawa APMS memiliki aktivitas antibakteri terhadap Escherichia coli. Rataan zona hambat yang terbentuk pada konsentrasi 5%; 10%; dan 15% secara berturut adalah 0,695 cm; 0,727 cm; dan 0,855 cm Konsentrasi yang optimal dari penelitian ini adalah pada konsentrasi 15% yang memberikan daya hambat yang paling besar.Kata kunci: Â Antibakteri; Asam p-metoksi sinamat; Escherichia coli

A Green Synthesis of Acetyl Eugenol by Sonochemical Method and Potential as Anti-Inflammatory In-Vitro Rahmawati Salsa Dinurrosifa; Erwin Indriyanti
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 7, No 3 (2022): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v7i3.66630

Clove oil is an essential oil from the clove plant (Syzygium aromaticum) containing eugenol compounds. One of the properties of eugenol is as an anti-inflammatory with a mechanism of inhibition of prostaglandin synthesis and neutrophil chemotaxis. Several derivatives of eugenol have active compounds that have been developed into new drug compounds as anti-inflammatory such as acetyl eugenol (4-allyl-2-methoxyphenyl acetate). This study aims to determine the % yield of acetyl eugenol produced from synthesis using ultrasonic 0.0323 mol of eugenol added to Erlenmeyer, and 0.25 mol of 10% sodium hydroxide was added. The mixture was put in a sonicator for 15 minutes and heated at 600C. Then, 0.0974 mol acetic anhydride was reacted with DCC, added to the mix and sonicated with time variations (60, 80, and 100 minutes). The chemical structure was elucidated using FTIR, ATR, and GC-MS. The synthesized % yield is 32.75%. Based on the interpretation data from FTIR, 3405 cm-1 is an O-H group (free phenol), 1405 cm-1 is an alkene group (C=C) aliphatic, and 1560 cm-1 is an aromatic compound with the presence of a C=C aromatic bond. The presence of the (C-O) ether group is indicated in the wave number at 1301 cm-1. The C=O ester bond in the ester group is shown at 1700 cm-1. GC-MS shows that the synthesized compound has a molecular ion with m/z = 206. According to the molecular weight of acetyl eugenol of 206 g/mol, it can be concluded that acetyl eugenol was successfully synthesized. The most stable ionic fragment, 37, has a molecular weight of m/z = 164. The activities of anti-inflammatory, acetyl eugenol compounds at 400 concentration ppm get % inhibition of 32.20%.

Sintesis Senyawa APMS (Asam p-Metoksisinamat) dan Potensinya sebagai Antikolesterol Rahmawati Salsa Dinurrosifa
Parapemikir : Jurnal Ilmiah Farmasi Vol 11, No 3 (2022): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v11i3.3926

Kolesterol dalam tubuh sangat dibutuhkan, namun dalam jumlah yang sesuai kadarnya dan tidak melebihi batas normal. Kolesterol yang melebihi batas normal dapat memicu berbagai penyakit dalam tubuh seperti jantung koroner, diabetes melitus, gangguan tiroid, penyakit hepar, dan lain sebagainya yang dapat mengganggu aktivitas seseorang atau bahkan dapat menyebabkan kematian. Senyawa turunan asam sinamat terdapat hampir di semua tanaman yang dapat dikembangkan menjadi senyawa obat baru sebagai penurun kadar kolesterol. Asam p-metoksisinamat (APMS) merupakan senyawa turunan dari asam sinamat yang diduga memiliki aktivitas penurun kadar kolesterol.. Tujuan dari penelitian ini adalah untuk mengetahui penurunan kadar kolesterol dengan variasi konsentrasi dan melihat nilai effective concentration (EC50) dari APMS. Analisis aktivitas penurunan kolesterol dilakukan berdasarkan metode Lieberman-Burchard dengan variasi konsentrasi 100 ppm, 200 ppm, 300 ppm, 400 ppm, dan 500 ppm. Hasil penelitian yang didapatkan menunjukkan aktivitas penurunan kadar kolesterol secara berurutan yaitu 42,76%, 46,60%, 49,04%, 52,36%, 56,90%. Nilai efektivitas (EC50) yang didapatkan sebesar 313,85 ppm. Cholesterol in the body is needed, but in appropriate amounts and does not exceed normal limits. Cholesterol that exceeds normal limits can trigger various diseases in the body such as coronary heart disease, diabetes mellitus, thyroid disorders, liver disease, and so on that can interfere with a person's activities or can even cause death. Cinnamic acid derivative compounds are found in almost all plants that can be developed into new medicinal compounds as cholesterol lowering agents. P-methoxycinnamic acid (APMS) is a compound derived from cinnamic acid which is thought to have cholesterol-lowering activity. The purpose of this study was to determine the decrease in cholesterol levels with variations in concentration and to see the value of the effective concentration (EC50) of the APMS. Analysis of cholesterol-lowering activity was carried out based on the Lieberman-Burchard method with various concentrations of 100 ppm, 200 ppm, 300 ppm, 400 ppm, and 500 ppm. The results obtained showed that the activity of reducing cholesterol levels was 42.76%, 46.60%, 49.04%, 52.36%, 56.90%. The effectiveness value (EC50) obtained is 313.85 ppm

The Antibacterial Activity Testing on Acetyleugenol Against Staphylococcus aereus Dinurrosifa, Rahmawati Salsa; Sulistyarini, Indah; Darumas P, Athika; Indriyanti, Erwin
Al-Kimia Vol 11 No 2 (2023): DESEMBER
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v11i2.42347

The main contents of clove oil are phenolic compounds, namely eugenol, eugenol acetate and gallic acid, as well as flavonoids. One of the derivatives of the eugenol compound is acetyl eugenol which was developed by the esterification reaction between eugenol and acetic acid anhydride using the sonochemical method. Synthesis of acetyleugenol was sonicated for 30 minutes at a temperature of 70-80°C. The % yield of the synthesized compound is calculated and continued with testing which includes solubility, melting point, FTIR and GC-MS tests, which are then tested for antimicrobial activity. The research results show that eugenol and acetic acid anhydride compounds with a NaOH catalyst can be synthesized using ultrasonic waves and produce a % yield of 3.50%. The resulting synthesis can melt starting at a temperature of 30°C and can dissolve in ethanol, methanol, chloroform and ether but does not dissolve in distilled water. FTIR testing on the acetyl eugenol compound showed the presence of -OH phenolic groups, C=C alkenes, C=C aromatics, C-O esters, and C=O esters. Acetyleugenol at concentrations of 1.25%, 2.5%, 5%, and 10% was able to act antibacterial on Staphylococcus aureus cultures with a density of 1.0 X 108 CFU/mL.

KAMPANYE PENTINGNYA MENEGAKKAN PROTOKOL KESEHATAN DI ERA PANDEMIK KEPADA MASYARAKAT DALAM ACARA CAR FREE DAY SIMPANG LIMA SEMARANG Astutiningsih, Christina; Dinurrosifa, Rahmawati Salsa; Sekarwati, Anisa; Riani, Elfa; Nadia, Lailatun; Wahyuni, Sri
Jurnal Pengabdian Masyarakat Sabangka Vol 1 No 04 (2022): Jurnal Pengabdian Masyarakat Sabangka
Publisher : Pusat Studi Ekonomi, Publikasi Ilmiah dan Pengembangan SDM Azramedia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/sabangka.v1i04.263

Saat era pandemi seperti sekarang kita dituntut agar tetap melakukan aktifitas seperti lazimnya tetapi harus dengan mematuhi peraturan agar rantai penyebaran virus COVID-19 dapat diputus. Penanganan covid-19 segera dapat dicapai dengan ditaati protokol kesehatan oleh masyarakat yaitu memakai masker; mencuci tangan dengan sabun, menjaga jarak, menghindari kerumunan dan mengurangi mobilitas (5M), vaksinas dan 3T (Tes, Telusuri, Tindak Lanjut) serta pelaksanaan vaksinasi untuk semua lapisan masyarakat Indonesia. Dengan taat prokes maka mata rantai penyebaran COVID-19 dapat segera diputus dan dapat kembali lagi melakukan aktifitas tanpa harus khawatir akan paparan dan bahaya virus ini. Untuk mendukung program Pemerintah tersebut maka STIFAR Yayasan Pharmasi Semarang merasa terpanggil untuk ikut terlibat melakukan kampanye menegakkan PROKES kepada masyarakat Semarang pada kegiatan Car Free Day di Taman Indonesia Kaya.

UJI AKTIVITAS EKSTRAK ETANOL DAN ISOLAT FLAVONOID KULIT KACANG TANAH (Arachis hypogaea L.) TERHADAP PENURUNAN KADAR ASAM URAT SECARA IN VITRO Dinurrosifa, Rahmawati Salsa; Mutiara, Erlita Verdia; Nafi’ah, Rohmatun
Media Farmasi Indonesia Vol. 11 No. 1 (2016): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.991 KB)

SARIHiperurisemia adalah suatu keadaan tingginya kadar asam urat yangdisebabkan terjadinya penumpukan asam urat secara berlebihan. Penurunan asamurat dapat digunakan obat alam dan obat sintetik. Obat alam yang digunakan salahsatunya kulit kacang tanah (Arachis hypogaea L.) yang banyak mengandungflavonoid dan mineral yang mampu menurunkan kadar asam urat. Penelitian inibertujuan untuk mengetahui perbedaanaktivitas pemberian ekstrak dan isolatflavonoid kulit kacang tanah (Arachis hypogaea L.) terhadap penurunan kadarasam urat secara in vitro, mengetahui persentase penurunan kadar asam uratsetelah penambahan ekstrak etanol dan isolat flavonoid kulit kacang tanah, sertamengetahuistruktur senyawa flavonoid dalam isolat kulit kacang tanah (Arachishypogaea L.). Metode ekstraksi yang digunakan dalam penelitian ini adalahmetode remaserasi. Isolasi senyawa flavonoid dilakukan dengan menggunakanmetode kromatografi kolom vakum, fase geraknya menggunakan n-heksan : etilasetat, dan fase diamnya menggunakan silika gel GF 60. Untuk uji penurunankadar asam urat, ekstrak dan isolat kulit kacang tanah dibuat deret konsentrasi100, 200, 300, 400, dan 500 ppm. Hasil uji anava satu jalan ekstrak menunjukkanbahwa ada perbedaan ekstrak etanol dan isolat flavonoid kulit kacang tanah dalammenurunkan kadar asam urat. Hasil persentase penurunan kadar asam urat setelahpenambahan ekstrak kulit kacang tanah berturut-turut sebesar 49,88; 54,13; 57,09;59,22 dan 61,06%, sedangkan setelah penambahan isolat flavonoid berturut-turutyaitu 40,26; 43,74; 47,94; 50,22; dan 52,92%. Struktur flavonoid dari kulit kacangtanah yang dapat menurunkan kadar asam urat secara in vitro yaitu senyawaturunan flavon dengan rumus 7,3’,4’-trihidroksi flavon.

Edukasi Pangan Sehat Sebagai Upaya Pencegahan Stunting Pada Anak di Desa Powelua, Kabupaten Donggala Mariyani, Mariyani; Muthmainnah A.R, Sririzqi; Dinurrosifa, Rahmawati Salsa; Marzuki, Sitti Aisyah
Amaliah: Jurnal Pengabdian Kepada Masyarakat Vol 8 No 2 (2024): Amaliah Jurnal: Pengabdian kepada Masyarakat
Publisher : LPPI UMN AL WASHLIYAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/ajpkm.v8i2.3219

Pangan sebagai kebutuhan dasar manusia harus mempunyai gizi yang seimbang, makanan atau minuman yang dikonsumsi berperan penting pada kesehatan manusia dan khususnya pertumbuhan anak. Mengkonsumsi pangan yang tidak sehat dapat menyebabkan penurunan kesehatan dan stunting pada anak sehingga pangan yang sehat sangat penting dalam kehidupan sehari-hari. Untuk menunjang pengetahuan orang tua dalam pemberian pangan sehat, dilakukan suatu kegiatan pengabdian kepada masyarakat yang bertujuan memberikan edukasi kepada masyarakat desa Powelua mengenai pangan sehat tanpa bahan kimia berbahaya untuk mencegah stunting pada anak dengan metode sosialisasi dan diskusi menggunakan media banner. Hasil kegiatan ini menunjukkan peningkatan pengetahuan mengenai stunting serta makanan yang sehat sebagai upaya dalam pencegahan stunting dengan persentase pre test (38%) dan post test (58%). Kegiatan ini juga dijadikan sebagai upaya dalam meningkatkan konsumsi pangan sehat seperti buah, sayur dan protein untuk meningkatkan status sehat khususnya pada anak

Comparative Dissolution Study Between Resveratrol Nanocream Formula and Conventional Resveratrol Cream with Dimethylsulfoxide Addition Dewi Fitriani Puspitasari; Rahmawati Salsa Dinurrosifa
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.9660

Resveratrol has potential activity as an antioxidant. Several studies have formulated resveratrol into topical preparations, but the low solubility of resveratrol causes low release of the active substance. Dimethylsulfoxide is a widely used ingredient in topical preparations, which can be used to increase the solubility of poorly soluble substances Nanocream is a nanoparticle-based topical drug delivery. The globule size is nanoscale, which can help improve drug solubility. The aim of the research was to conduct a comparative dissolution study between resveratrol nanocream formula and resveratrol conventional cream preparation with the addition of dimethylsulfoxide at various concentrations of 3%, 5% and 7%. The research method began with formulating resveratrol nanocream preparation. The preparation consisted of lipid components dispersed into a cream base. The lipids consisted of VCO, tween 80 and propylenglycol. Loading drug of resveratrol lipid was 300 mg, then tested for transimtance value and globule size. Conventional resveratrol cream formula was made into FI, FII and FIII, where each formula used different concentration of DMSO. Physical characteristics testing was conducted on nanocream and conventional resveratrol cream.Analysis of dissolution test results was observed among FI, FII and FIII in conventional cream formulas. The dissolution test results of these three formulas were also compared with the resveratrol nanocream preparation. Observation of dissolution results was assessed from the percentage of active substance released at minutes 5, 10, 15, 30, 45, 60.The dissolution test results showed that there was no significant difference in the percentage of active substance released between the conventional resveratrol cream preparation formulas, but there was a significant difference between the three conventional resveratrol cream preparation formulas and the resveratrol nanocream preparation.

Pelatihan Pembuatan Lotion Anti Nyamuk Herbal Kombinasi Daun Sereh dan Daun Pandan sebagai Upaya Perlindungan terhadap Gigitan Nyamuk pada PKK di Kelurahan Sukorejo, Kota Semarang Anggita Dipika Wulandari; Rifda Naufa Lina; Rahmawati Salsa Dinurrosifa
SEWAGATI: Jurnal Pengabdian Masyarakat Indonesia Vol. 4 No. 3 (2025): September : Jurnal Pengabdian Masyarakat Indonesia
Publisher : BADAN PENERBIT STIEPARI PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56910/sewagati.v4i3.3107

The rainy season in Sukorejo Village, Semarang City, increases mosquito populations due to stagnant water, potentially transmitting diseases such as dengue fever, malaria, and chikungunya. The community still relies on chemical-based mosquito repellent lotions containing DEET, which carry risks of skin irritation, allergies, and potential toxicity. Natural ingredients such as lemongrass (Cymbopogon nardus) and pandan leaves (Pandanus amaryllifolius) contain active compounds—citronellal, geraniol, alkaloids, flavonoids, and polyphenols—that are effective as natural repellents. The purpose of this activity is to enhance the knowledge and skills of PKK women in utilizing lemongrass and pandan leaves for the production of safe, effective, and environmentally friendly herbal mosquito repellent lotion. The program was implemented in four stages: (1) health education on mosquito-borne diseases and active plant compounds, (2) training on herbal lotion production covering raw material selection, hygienic processing, formulation, and packaging, and (3) production assistance by the community service team. Methods included lectures, discussions, demonstrations, and hands-on practice. The program improved participants’ understanding of natural repellents and their ability to independently produce herbal lotion. The lemongrass–pandan lotion produced met safety standards, had a pleasant aroma, and was effective in protecting against mosquito bites. This training effectively increased the capacity of PKK members, reduced dependency on commercial chemical-based products, and opened opportunities for local, small-scale businesses.

KAMPANYE PENTINGNYA MENEGAKKAN PROTOKOL KESEHATAN DI ERA PANDEMIK KEPADA MASYARAKAT DALAM ACARA CAR FREE DAY SIMPANG LIMA SEMARANG Astutiningsih, Christina; Dinurrosifa, Rahmawati Salsa; Sekarwati, Anisa; Riani, Elfa; Nadia, Lailatun; Wahyuni, Sri
Jurnal Pengabdian Masyarakat Sabangka Vol 1 No 04 (2022): Jurnal Pengabdian Masyarakat Sabangka
Publisher : Pusat Studi Ekonomi, Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/sabangka.v1i04.263

Saat era pandemi seperti sekarang kita dituntut agar tetap melakukan aktifitas seperti lazimnya tetapi harus dengan mematuhi peraturan agar rantai penyebaran virus COVID-19 dapat diputus. Penanganan covid-19 segera dapat dicapai dengan ditaati protokol kesehatan oleh masyarakat yaitu memakai masker; mencuci tangan dengan sabun, menjaga jarak, menghindari kerumunan dan mengurangi mobilitas (5M), vaksinas dan 3T (Tes, Telusuri, Tindak Lanjut) serta pelaksanaan vaksinasi untuk semua lapisan masyarakat Indonesia. Dengan taat prokes maka mata rantai penyebaran COVID-19 dapat segera diputus dan dapat kembali lagi melakukan aktifitas tanpa harus khawatir akan paparan dan bahaya virus ini. Untuk mendukung program Pemerintah tersebut maka STIFAR Yayasan Pharmasi Semarang merasa terpanggil untuk ikut terlibat melakukan kampanye menegakkan PROKES kepada masyarakat Semarang pada kegiatan Car Free Day di Taman Indonesia Kaya.

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