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All Journal Jurnal Farmasi Indonesia Emasains : Jurnal Edukasi Matematika dan Sains
Ni Nyoman Yudianti Mendra
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Education Environmental Science Immunology & microbiology Mathematics Medicine & Pharmacology

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Formulasi Gel Ekstrak Metanol Bunga Cempaka Putih (Magnolia alba) sebagai Antijerawat terhadap Bakteri Staphylococcus aureus Ni Nyoman Yudianti Mendra; Kadek Desy Aryantini; Debby Juliadi
Jurnal Farmasi Indonesia Vol 21 No 2 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i2.2152

Abstract

The white champaca flower is an evergreen plant that thrives in Bali, local populations take advantages of its fragrance for ritual purposes and aromatherapy. The antibacterial, antifungal, and antioxidant activity of the white champaca flower (Magnolia alba) are well-known, besides its utility as aromatherapy. These activities were attributed to the presence of secondary metabolites such as flavonoid, tannin, steroid, and saponin. This study aimed to determine the antibacterial activity of methanol extract of Magnolia alba formulated as a gel against Staphylococcus aureus. Gel formulations were prepared using various concentration of extract FI (4%), FII (6%), and FIII (8%). The physical tests included organoleptic, homogeneity, pH, dispersibility, and adhesion test. The antibacterial activity was evaluated using agar well diffusion method, with Clindamycin gel as the positive control. Statistical analysis of the inhibition zone was conducted using a Post Hoc test at a 95% confidence level. The addition of extract in each formula affected its physical properties, particularly the dispersibility. The gel exhibited a spreadability range of 2,67 – 4,22 cm, which fell below the standard 5-7 cm. The gel viscosity increased with a higher concentration of extract, resulting in reduced spreadability of the gel. The Inhibition zone of the sample against S.aureus was observed with an inhibition diameter of 6,33 mm and 11,37 mm for FII and FIII, respectively, compared to the positive control of 22,17 mm. These findings indicate that the methanol extract gel of Magnolia alba can inhibit the growth of S.aureus and has the potential as an anti-acne gel with moderate and strong inhibitory effects. The inhibitory activity of the gel against bacteria increased with a higher concentration of the extract.
PENGUJIAN MUTU FISIK FORMULASI SEDIAAN SABUN PADAT BERBAHAN SUSU KEDELAI Sanjiwani, Ni Made Sukma Sanjiwani; Ni Nyoman Yudianti Mendra; Agus Sudharmayasa
Emasains : Jurnal Edukasi Matematika dan Sains Vol. 13 No. 1 (2024): Maret 2024
Publisher : Program Studi Pendidikan Matematika dan Pendidikan Biologi Universitas PGRI Mahadewa Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59672/emasains.v13i1.3602

Abstract

Soap is a product formed through the reaction between fatty acids and strong bases, which has a function as a dirt cleaner. Soap containing Sodium Lauryl Sulfate (SLS) can cause irritation for users with sensitive skin types. The use of natural ingredients is highly considered to minimize the side effects of using synthetics. Soy milk is one of the natural ingredients that can be utilized because it contains antioxidant compounds that are beneficial to ward off free radicals on the skin. Soy milk also contains saponin compounds, a natural ingredient used as a soap foaming agent that is more environmentally friendly than chemicals. This study aims to evaluate the physical quality of soy milk solid soap dosage formulations. In this study, four soap formulas were made with variations in soy milk concentrations of 11, 15 and 19%. The physical quality test parameters included organoleptic test, homogeneity test, pH test, and foam height test. The research data was analyzed with SPSS version 25 with the Kruskal-Wallis test with a confidence level of 95%. Based on the results of the study, soy milk solid soap was obtained with good physical quality including organoleptic, homogeneity and foam height. However, the pH value of soy milk solid soap does not comply with the provisions imposed for soap products.
Co-Authors Agus Sudharmayasa Debby Juliadi Kadek Desy Aryantini Sanjiwani, Ni Made Sukma Sanjiwani