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Safat Wahyudi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Mechanical Engineering Public Health

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Diagnosis dan Tatalaksana Guillain Barré Syndrome Grandis Cristagalli; Herpan Syafii Harahap; Safat Wahyudi; Aulia Dwi Hendriani; Izza Mufida; Muhammad Sutan Maulana; Rike Delya Rizqina
Lombok Medical Journal Vol. 3 No. 1 (2024): Lombok Medical Journal Volume 3 Nomor 1
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v3i1.2886

Abstract

Guillain-Barré Syndrome or GBS is one of the emergency conditions of neurology. Currently, its incidence is relatively low and rare, with a rate of 0.81 to 1.89 of 100,000 people in a year. Guillain-Barré Syndrome or GBS, also known as acute inflammatory demyelinating polyradiculoneuropathy, is a collection of clinical symptoms caused by an acute inflammatory process that attacks the nervous system. The dominant pathogen that causes Guillain-Barré Syndrome (GBS) is Campylobacter jejuni (C. jejuni). Infection with the pathogen Campylobacter jejuni can trigger an immune and humoral autoimmune response that results in nerve dysfunction and the emergence of GBS symptoms. The clinical course of GBS can be divided into several phases, including the progressive phase, plateau phase, and recovery phase. In cases of GBS, it is possible that these factors are involved in the onset of the disease. Some risk factors associated with GBS include viral infections such as Zika virus, influenza virus, and measles-rubella virus. The diagnosis of GBS includes the main symptoms, additional symptoms, cerebrospinal fluid examination, electrophysiological tests, and the exclusion of other diagnoses. The main symptoms include progressive weakness in the extremities accompanied by or without ataxia and areflexia or hyporeflexia in the tendons. The management that can be done includes supportive therapy through the respiratory system. Another treatment option is immunotherapy, with the goal of accelerating disease recovery and reducing the severity of GBS through the immune system.
Patofisiologi Ensefalitis pada Rabies Safat Wahyudi; Raditya Rachman Landapa
Lombok Medical Journal Vol. 3 No. 2 (2024): Lombok Medical Journal Volume 3 Nomor 2
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v3i2.4527

Abstract

Rabies, disebabkan oleh Rabies Lyssavirus, virus neurotropik yang menargetkan neuron dan menyebar sepanjang sel saraf, menghasilkan disfungsi neuronal. Virus ini menunjukkan neurotropisme dan neuro-invasivitas yang kuat, menyebabkan manifestasi neurologis yang parah. Penularan penyakit ini biasanya melalui gigitan hewan yang terinfeksi, memungkinkan virus masuk ke dalam tubuh dan bereplikasi sebelum mencapai otak atau medula spinalis. Rabies muncul dalam dua bentuk yang berbeda, yaitu ensefalitik dan paralitik, dengan rabies ensefalitik lebih umum dan ditandai dengan gejala klasik seperti hidrofobia dan aerofobia. Tanda-tanda awal dapat mencakup kesemutan pada anggota tubuh tanpa gangguan kognitif. Pemahaman terhadap patofisiologi serta interaksi antara virus Rabies dan host, antara lain mekanisme masuknya virus, replikasi, dan penyebaran dalam sistem saraf sangat penting untuk menjelaskan tentang proses perjalanan penyakit, termasuk perubahan perilaku yang terjadi. Pencegahan rabies melibatkan vaksinasi yang tepat waktu setelah paparan, sementara pengobatan pasca-infeksi yang adekuat hingga saat ini masih menjadi tantangan.
Diagnosis dan Tatalaksana Guillain Barré Syndrome Grandis Cristagalli; Harahap, Herpan Syafii; Safat Wahyudi; Aulia Dwi Hendriani; Izza Mufida; Muhammad Sutan Maulana; Rike Delya Rizqina
Lombok Medical Journal Vol. 3 No. 1 (2024): Lombok Medical Journal Volume 3 Nomor 1
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v3i1.2886

Abstract

Guillain-Barré Syndrome or GBS is one of the emergency conditions of neurology. Currently, its incidence is relatively low and rare, with a rate of 0.81 to 1.89 of 100,000 people in a year. Guillain-Barré Syndrome or GBS, also known as acute inflammatory demyelinating polyradiculoneuropathy, is a collection of clinical symptoms caused by an acute inflammatory process that attacks the nervous system. The dominant pathogen that causes Guillain-Barré Syndrome (GBS) is Campylobacter jejuni (C. jejuni). Infection with the pathogen Campylobacter jejuni can trigger an immune and humoral autoimmune response that results in nerve dysfunction and the emergence of GBS symptoms. The clinical course of GBS can be divided into several phases, including the progressive phase, plateau phase, and recovery phase. In cases of GBS, it is possible that these factors are involved in the onset of the disease. Some risk factors associated with GBS include viral infections such as Zika virus, influenza virus, and measles-rubella virus. The diagnosis of GBS includes the main symptoms, additional symptoms, cerebrospinal fluid examination, electrophysiological tests, and the exclusion of other diagnoses. The main symptoms include progressive weakness in the extremities accompanied by or without ataxia and areflexia or hyporeflexia in the tendons. The management that can be done includes supportive therapy through the respiratory system. Another treatment option is immunotherapy, with the goal of accelerating disease recovery and reducing the severity of GBS through the immune system.
Co-Authors Aulia Dwi Hendriani Aulia Dwi Hendriani Grandis Cristagalli Grandis Cristagalli Herpan Syafii Harahap Herpan Syafii Harahap Izza Mufida Izza Mufida Muhammad Sutan Maulana Muhammad Sutan Maulana Raditya Rachman Landapa Rike Delya Rizqina Rike Delya Rizqina