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All Journal Pharmaciana: Jurnal Kefarmasian AJAD : Jurnal Pengabdian kepada Masyarakat Borneo Journal of Pharmacy
Fawaid, Ainun
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Humanities Medicine & Pharmacology

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Chemical Compound Profile of Bajakah Kalalawit (Uncaria gambir Roxb) Stem Extract Using Liquid Chromatography High-Resolution Mass Spectrometry Fawaid, Ainun; Mahfudh, Nurkhasanah
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.7942

Abstract

Uncaria gambir Roxb., commonly known as Bajakah Kalalawit, is a plant endemic to Kalimantan, Indonesia, with potential medicinal properties. While previous studies have investigated the phytochemical composition of U. gambir leaves, limited information exists regarding the constituents of its stem extract. This study aimed to comprehensively characterize the chemical composition of U. gambir stem extract using Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS). Ethanol (96%) was employed as the solvent for maceration extraction (1 : 5, plant material : solvent ratio) for three days. Subsequently, the dried extract was subjected to LC-HRMS analysis. Compounds with an Area Under the Curve (AUC) value greater than or equal to 1% were considered as major constituents. The results revealed the presence of 18 distinct chemical compounds in the U. gambir stem extract, providing valuable insights into its phytochemical profile and laying the foundation for further investigations into its potential pharmacological activities.
In silico and in vitro studies of flavanoid content of Uncaria gambir Roxb stem extract on antidiabetic activity Fawaid, Ainun; Mahfudh, Nurkhasanah; Utami, Dwi; Mohamed, Farahidah
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.30765

Abstract

Bajakah Kalalawit (Uncaria gambir Roxb.) is a typical plant of the Dayak tribe of Kalimantan, Indonesia. This study aims to evaluate the antidiabetic potential of Bajakah Kalalawit stem extract through in silico and in vitro approaches. In silico analysis was conducted to identify the interaction of bioactive compounds in 96% ethanol extract of Bajakah Kalalawit stems with the alpha-glucosidase enzyme (PDB ID : 5NN8), which is the main target in the treatment of diabetes. The results of molecular simulations showed that 2 bioactive compounds of the flavonoid group, namely Bikisocoumarin (-8.25 kcal/mol) and Pinostrobin (-5.81 kcal/mol) contained in 96% ethanol extract of Bajakah Kalalawit stems have significant inhibitory potential against the enzyme. Furthermore, in vitro tests were conducted to assess the inhibitory activity against the alpha-glucosidase enzyme and its effect on reducing blood glucose levels. The experimental results showed that 96% ethanol extract of Bajakah Kalalawit stems was able to significantly (ρ < 0.05) inhibit alpha-glucosidase activity (IC50 = 0.296 ± 0.004 μg/mL). This finding indicates that Bajakah Kalalawit has the potential as a source of active antidiabetic ingredients that can be further developed as an alternative therapy for diabetes management.
Edukasi Kesehatan Gizi dan Deteksi Sederhana Yodium: Strategi Preventif Gangguan Akibat Kekurangan Yodium (GAKY) di Kalangan Siswa MA Asshodiqiyah Lestari, Asih Puji; Kusumawati, Dwi Endah; Fawaid, Ainun; Haekal, Ghulam; Agustin, Stevi
AJAD : Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 1 (2026): APRIL 2026
Publisher : Divisi Riset, Lembaga Mitra Solusi Teknologi Informasi (L-MSTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59431/ajad.v6i1.761

Abstract

Iodine Deficiency Disorders (IDD) remain a serious threat to the health and cognitive development of adolescents. This community service activity aims to improve nutritional health literacy and practical skills among students of MA Asshodiqiyah Semarang in detecting iodine content in salt. The implementation method included interactive education, evaluation through pre-tests and post-tests, and hands-on practice of simple iodine testing. The program was conducted in December 2025 and involved 15 tenth-grade students at MA Asshodiqiyah. The results showed a significant increase in student understanding, with average knowledge scores rising from 58 (pre-intervention) to 86 (post-intervention). The skills evaluation further revealed that 85% of students were able to perform iodine testing independently and correctly. The combination of theoretical education and direct practice proved effective in raising students' critical awareness of the quality of salt they consume. This activity is expected to serve as a sustainable preventive strategy to combat IDD within school and pesantren (Islamic boarding school) environments.
Co-Authors Agustin, Stevi Dwi Endah Kusumawati Haekal, Ghulam Lestari, Asih Puji Mohamed, Farahidah Muhammad Yusron Maulana El-Yunusi Nurkhasanah Mahfudh